| Direct activation of STING in the tumor microenvironment leads to potent and systemic tumor regression and immunity L Corrales, LH Glickman, SM McWhirter, DB Kanne, KE Sivick, ... Cell reports 11 (7), 1018-1030, 2015 | 1458 | 2015 |
| STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade J Fu, DB Kanne, M Leong, LH Glickman, SM McWhirter, E Lemmens, ... Science translational medicine 7 (283), 283ra52-283ra52, 2015 | 789 | 2015 |
| Magnitude of therapeutic STING activation determines CD8+ T cell-mediated anti-tumor immunity KE Sivick, AL Desbien, LH Glickman, GL Reiner, L Corrales, NH Surh, ... Cell reports 25 (11), 3074-3085. e5, 2018 | 367 | 2018 |
| Radiotherapy combined with novel STING-targeting oligonucleotides results in regression of established tumors JR Baird, D Friedman, B Cottam, TW Dubensky Jr, DB Kanne, S Bambina, ... Cancer research 76 (1), 50-61, 2016 | 248 | 2016 |
| Isolation and characterization of pyrimidine-psoralen-pyrimidine photodiadducts from DNA D Kanne, K Straub, JE Hearst, H Rapoport Journal of the American Chemical Society 104 (24), 6754-6764, 1982 | 247 | 1982 |
| The psoralen-DNA photoreaction. Characterization of the monoaddition products from 8-methoxypsoralen and 4, 5', 8-trimethylpsoralen D Kanne, K Straub, H Rapoport, JE Hearst Biochemistry 21 (5), 861-871, 1982 | 244 | 1982 |
| The reaction of the psoralens with deoxyribonucleic acid JE Hearst, ST Isaacs, D Kanne, H Rapoport, K Straub Quarterly reviews of biophysics 17 (1), 1-44, 1984 | 214 | 1984 |
| Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants TW Dubensky Jr, DB Kanne, ML Leong Therapeutic advances in vaccines 1 (4), 131-143, 2013 | 212 | 2013 |
| Isolation and characterization of pyrimidine-psoralen photoadducts from DNA K Straub, D Kanne, JE Hearst, H Rapoport Journal of the American Chemical Society 103 (9), 2347-2355, 1981 | 163 | 1981 |
| A STING agonist given with OX40 receptor and PD-L1 modulators primes immunity and reduces tumor growth in tolerized mice JB Foote, M Kok, JM Leatherman, TD Armstrong, BC Marcinkowski, ... Cancer immunology research 5 (6), 468-479, 2017 | 156 | 2017 |
| STING-activating adjuvants elicit a Th17 immune response and protect against Mycobacterium tuberculosis infection E Van Dis, KM Sogi, CS Rae, KE Sivick, NH Surh, ML Leong, DB Kanne, ... Cell reports 23 (5), 1435-1447, 2018 | 128 | 2018 |
| Compositions and methods for activating stimulator of interferon gene-dependent signalling TW Dubensky Jr, DB Kanne, MLL Leong, EE Lemmens, LH Glickman, ... US Patent 9,724,408, 2017 | 100 | 2017 |
| Structure of a psoralen-thymine monoadduct formed in photoreaction with DNA S Peckler, B Graves, D Kanne, H Rapoport, JE Hearst, SH Kim Journal of molecular biology 162 (1), 157-172, 1982 | 99 | 1982 |
| Identification of aldehyde oxidase as the neonicotinoid nitroreductase RA Dick, DB Kanne, JE Casida Chemical research in toxicology 18 (2), 317-323, 2005 | 90 | 2005 |
| Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling TW Dubensky Jr, DB Kanne US Patent 9,549,944, 2017 | 87 | 2017 |
| Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids DB Kanne, LG Abood Journal of medicinal chemistry 31 (3), 506-509, 1988 | 82 | 1988 |
| Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use TW Dubensky Jr, DB Kanne, MLL Leong, EE Lemmens, LH Glickman US Patent 9,695,212, 2017 | 79 | 2017 |
| Neonicotinoid nitroguanidine insecticide metabolites: synthesis and nicotinic receptor potency of guanidines, aminoguanidines, and their derivatives DB Kanne, RA Dick, M Tomizawa, JE Casida Chemical research in toxicology 18 (9), 1479-1484, 2005 | 67 | 2005 |
| Synthesis of the first highly potent bridged nicotinoid 9-Azabicyclo [4.2. 1] nona [2, 3-c] pyridine (pyrido [3, 4-b] homotropane) DB Kanne, DJ Ashworth, MT Cheng, LC Mutter, LG Abood Journal of the American Chemical Society 108 (24), 7864-7865, 1986 | 62 | 1986 |
| Synthesis and derivatization of 8-acetylpsoralens. Acetyl migrations during Claisen rearrangement DR Bender, D Kanne, JD Frazier, H Rapoport The Journal of Organic Chemistry 48 (16), 2709-2719, 1983 | 58 | 1983 |