| PML regulates p53 acetylation and premature senescence induced by oncogenic Ras M Pearson, R Carbone, C Sebastiani, M Cioce, M Fagioli, S Saito, ... Nature 406 (6792), 207-210, 2000 | 1082 | 2000 |
| Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis G D'Orazi, B Cecchinelli, T Bruno, I Manni, Y Higashimoto, S Saito, ... Nature cell biology 4 (1), 11-19, 2002 | 854 | 2002 |
| MDM2–HDAC1‐mediated deacetylation of p53 is required for its degradation A Ito, Y Kawaguchi, CH Lai, JJ Kovacs, Y Higashimoto, E Appella, TP Yao The EMBO journal, 2002 | 726 | 2002 |
| Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase DV Bulavin, Y Higashimoto, IJ Popoff, WA Gaarde, V Basrur, O Potapova, ... Nature 411 (6833), 102-107, 2001 | 712 | 2001 |
| Nitric oxide-induced cellular stress and p53 activation in chronic inflammation LJ Hofseth, S Saito, SP Hussain, MG Espey, KM Miranda, Y Araki, ... Proceedings of the national academy of sciences 100 (1), 143-148, 2003 | 426 | 2003 |
| ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation∗ S Saito, AA Goodarzi, Y Higashimoto, Y Noda, SP Lees-Miller, E Appella, ... Journal of Biological Chemistry 277 (15), 12491-12494, 2002 | 425 | 2002 |
| Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase: effect on Mdm2 binding K Sakaguchi, S Saito, Y Higashimoto, S Roy, CW Anderson, E Appella Journal of Biological Chemistry 275 (13), 9278-9283, 2000 | 404 | 2000 |
| p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity M Shiseki, M Nagashima, RM Pedeux, M Kitahama-Shiseki, K Miura, ... Cancer research 63 (10), 2373-2378, 2003 | 391 | 2003 |
| A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes B Livingston, C Crimi, M Newman, Y Higashimoto, E Appella, J Sidney, ... The Journal of Immunology 168 (11), 5499-5506, 2002 | 370 | 2002 |
| Characterization of rat heme oxygenase-3 gene. Implication of processed pseudogenes derived from heme oxygenase-2 gene S Hayashi, Y Omata, H Sakamoto, Y Higashimoto, T Hara, Y Sagara, ... Gene 336 (2), 241-250, 2004 | 364 | 2004 |
| A urokinase‐sensitive region of the human urokinase receptor is responsible for its chemotactic activity F Fazioli, M Resnati, N Sidenius, Y Higashimoto, E Appella, F Blasi The EMBO Journal, 1997 | 316 | 1997 |
| Phosphorylation site interdependence of human p53 post-translational modifications in response to stress S Saito, H Yamaguchi, Y Higashimoto, C Chao, Y Xu, AJ Fornace, ... Journal of Biological Chemistry 278 (39), 37536-37544, 2003 | 311 | 2003 |
| Dual phosphorylation controls Cdc25 phosphatases and mitotic entry DV Bulavin, Y Higashimoto, ZN Demidenko, S Meek, P Graves, C Phillips, ... Nature cell biology 5 (6), 545-551, 2003 | 210 | 2003 |
| Proteomic analysis of early melanosomes: identification of novel melanosomal proteins V Basrur, F Yang, T Kushimoto, Y Higashimoto, K Yasumoto, J Valencia, ... Journal of proteome research 2 (1), 69-79, 2003 | 207 | 2003 |
| Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like … Y Ishibashi, T Matsui, S Maeda, Y Higashimoto, S Yamagishi Cardiovascular diabetology 12, 1-9, 2013 | 182 | 2013 |
| Human p53 is phosphorylated on serines 6 and 9 in response to DNA damage-inducing agents Y Higashimoto, S Saito, XH Tong, A Hong, K Sakaguchi, E Appella, ... Journal of Biological Chemistry 275 (30), 23199-23203, 2000 | 179 | 2000 |
| HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles DL Doolan, S Southwood, R Chesnut, E Appella, E Gomez, A Richards, ... The journal of immunology 165 (2), 1123-1137, 2000 | 163 | 2000 |
| A novel secreted protease from Pseudomonas aeruginosa activates NF‐κB through protease‐activated receptors Y Kida, Y Higashimoto, H Inoue, T Shimizu, K Kuwano Cellular microbiology 10 (7), 1491-1504, 2008 | 149 | 2008 |
| Identification and antigenicity of broadly cross-reactive and conserved human immunodeficiency virus type 1-derived helper T-lymphocyte epitopes CC Wilson, B Palmer, S Southwood, J Sidney, Y Higashimoto, E Appella, ... Journal of virology 75 (9), 4195-4207, 2001 | 134 | 2001 |
| Binding specificity of multiprotein signaling complexes is determined by both cooperative interactions and affinity preferences JCD Houtman, Y Higashimoto, N Dimasi, S Cho, H Yamaguchi, ... Biochemistry 43 (14), 4170-4178, 2004 | 132 | 2004 |
