| Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy S Asamitsu, S Obata, Z Yu, T Bando, H Sugiyama Molecules 24 (3), 429, 2019 | 282 | 2019 |
| The RAF-MEK-ERK pathway: Targeting ERK to overcome obstacles of effective cancer therapy Z Yu, S Ye, G Hu, M Lv, Z Tu, K Zhou, Q Li Future medicinal chemistry 7 (3), 269-289, 2015 | 84 | 2015 |
| Therapeutic gene regulation using pyrrole–imidazole polyamides Z Yu, GN Pandian, T Hidaka, H Sugiyama Advanced Drug Delivery Reviews 147, 66-85, 2019 | 43 | 2019 |
| G-quadruplex DNA structure is a positive regulator of MYC transcription I Esain-Garcia, A Kirchner, L Melidis, RCA Tavares, S Dhir, A Simeone, ... Proceedings of the National Academy of Sciences 121 (7), e2320240121, 2024 | 38 | 2024 |
| Soluble guanylate cyclase stimulators and activators: where are we and where to go? S Xiao, Q Li, L Hu, Z Yu, J Yang, Q Chang, Z Chen, G Hu Mini Reviews in Medicinal Chemistry 19 (18), 1544-1557, 2019 | 36 | 2019 |
| Pip-HoGu: an artificial assembly with cooperative DNA recognition capable of mimicking transcription factor pairs Z Yu, C Guo, Y Wei, K Hashiya, T Bando, H Sugiyama Journal of the American Chemical Society 140 (7), 2426-2429, 2018 | 33 | 2018 |
| Chem-map profiles drug binding to chromatin in cells Z Yu, J Spiegel, L Melidis, WWI Hui, X Zhang, A Radzevičius, ... Nature Biotechnology 41, 1265-1270, 2023 | 31 | 2023 |
| Mitochondria and G-quadruplex evolution: an intertwined relationship VJ Sahayasheela, Z Yu, T Hidaka, GN Pandian, H Sugiyama Trends in Genetics 39 (1), 15-30, 2023 | 27 | 2023 |
| Current advances in idiopathic pulmonary fibrosis: the pathogenesis, therapeutic strategies and candidate molecules M Lv, Y Liu, S Ma, Z Yu Future medicinal chemistry 11 (19), 2595-2620, 2019 | 25 | 2019 |
| Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors J Ma, H Chen, J Yang, Z Yu, P Huang, H Yang, B Zheng, R Liu, Q Li, G Hu, ... Bioorganic & Medicinal Chemistry 27 (9), 1871-1881, 2019 | 23 | 2019 |
| Antiproliferative and apoptotic activities of sequence-specific histone acetyltransferase inhibitors Z Yu, J Taniguchi, Y Wei, GN Pandian, K Hashiya, T Bando, H Sugiyama European Journal of Medicinal Chemistry 138, 320-327, 2017 | 23 | 2017 |
| Chemical probe-based nanopore sequencing to selectively assess the RNA modifications S Ramasamy, VJ Sahayasheela, S Sharma, Z Yu, T Hidaka, L Cai, ... ACS chemical biology 17 (10), 2704-2709, 2022 | 21 | 2022 |
| Direct observation of H3–H4 octasome by high‐speed AFM T Zou, F Hashiya, Y Wei, Z Yu, GN Pandian, H Sugiyama Chemistry–A European Journal 24 (60), 15998-16002, 2018 | 21 | 2018 |
| Dual inhibitors of RAF-MEK-ERK and PI3K-PDK1-AKT pathways: Design, synthesis and preliminary anticancer activity studies of 3-substituted-5-(phenylamino) indolone derivatives Z Yu, Z Chen, Q Su, S Ye, H Yuan, M Kuai, M Lv, Z Tu, X Yang, RR Liu, ... Bioorganic & Medicinal Chemistry 27 (6), 944-954, 2019 | 19 | 2019 |
| Direct Observation of the Double‐Stranded DNA Formation through Metal Ion‐Mediated Base Pairing in the Nanoscale Structure X Xing, Y Feng, Z Yu, K Hidaka, F Liu, A Ono, H Sugiyama, M Endo Chemistry–A European Journal 25 (6), 1446-1450, 2019 | 19 | 2019 |
| A synthetic transcription factor pair mimic for precise recruitment of an epigenetic modifier to the targeted DNA locus Z Yu, M Ai, SK Samanta, F Hashiya, J Taniguchi, S Asamitsu, S Ikeda, ... Chemical Communications 56 (15), 2296-2299, 2020 | 18 | 2020 |
| Orthogonal γPNA dimerization domains empower DNA binders with cooperativity and versatility mimicking that of transcription factor pairs Z Yu, WC Hsieh, S Asamitsu, K Hashiya, T Bando, DH Ly, H Sugiyama Chemistry–A European Journal 24 (53), 14183-14188, 2018 | 17 | 2018 |
| Inhibition of GLI-mediated transcription by cyclic pyrrole-imidazole polyamide in cancer stem cells VJ Sahayasheela, Z Yu, Y Hirose, GN Pandian, T Bando, H Sugiyama Bulletin of the Chemical Society of Japan 95 (4), 693-699, 2022 | 15 | 2022 |
| Synthetic DNA-binding inhibitor of HES1 alters the notch signaling pathway and induces neuronal differentiation Y Wei, GN Pandian, Z Yu, T Zou, Y Li, J Darokar, K Hashiya, T Bando, ... ACS omega 3 (3), 3608-3616, 2018 | 7 | 2018 |
| A novel PDK1/MEK dual inhibitor induces cytoprotective autophagy via the PDK1/akt signaling pathway in non-small cell lung cancer R Liu, Z Chen, G Hu, Z Yu, Q Li, D Liu, L Li, Z Liu Pharmaceuticals 16 (2), 244, 2023 | 4 | 2023 |
Hiroshi SugiyamaKyoto Universityכתובת אימייל מאומתת בדומיין kuchem.kyoto-u.ac.jp