עקוב אחר
Nicholas A. Meanwell
Nicholas A. Meanwell
Baruch S. Blumberg Institute, U. Michigan, Rutgers U.
כתובת אימייל מאומתת בדומיין bblumberg.org
כותרת
צוטט על ידי
צוטט על ידי
שנה
Applications of fluorine in medicinal chemistry
EP Gillis, KJ Eastman, MD Hill, DJ Donnelly, NA Meanwell
Journal of medicinal chemistry 58 (21), 8315-8359, 2015
33792015
Synopsis of some recent tactical application of bioisosteres in drug design
NA Meanwell
Journal of medicinal chemistry 54 (8), 2529-2591, 2011
29672011
Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design
NA Meanwell
Journal of medicinal chemistry 61 (14), 5822-5880, 2018
21422018
Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect
M Gao, RE Nettles, M Belema, LB Snyder, VN Nguyen, RA Fridell, ...
Nature 465 (7294), 96-100, 2010
11422010
The expanding role of prodrugs in contemporary drug design and development
J Rautio, NA Meanwell, L Di, MJ Hageman
Nature reviews drug discovery 17 (8), 559-587, 2018
7522018
A survey of the role of noncovalent sulfur interactions in drug design
BR Beno, KS Yeung, MD Bartberger, LD Pennington, NA Meanwell
Journal of medicinal chemistry 58 (11), 4383-4438, 2015
7182015
Improving drug candidates by design: a focus on physicochemical properties as a means of improving compound disposition and safety
NA Meanwell
Chemical research in toxicology 24 (9), 1420-1456, 2011
6272011
Metabolic and pharmaceutical aspects of fluorinated compounds
BM Johnson, YZ Shu, X Zhuo, NA Meanwell
Journal of medicinal chemistry 63 (12), 6315-6386, 2020
5372020
A small molecule HIV-1 inhibitor that targets the HIV-1 envelope and inhibits CD4 receptor binding
PF Lin, W Blair, T Wang, T Spicer, Q Guo, N Zhou, YF Gong, HGH Wang, ...
Proceedings of the National Academy of Sciences 100 (19), 11013-11018, 2003
4902003
Bioisosteres of the phenyl ring: recent strategic applications in lead optimization and drug design
MAM Subbaiah, NA Meanwell
Journal of Medicinal Chemistry 64 (19), 14046-14128, 2021
4092021
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
VK Gribkoff, JE Starrett, SI Dworetzky, P Hewawasam, CG Boissard, ...
Nature medicine 7 (4), 471-477, 2001
3562001
Discovery of 4-Benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806):  A Novel HIV-1 Attachment Inhibitor That …
T Wang, Z Zhang, OB Wallace, M Deshpande, H Fang, Z Yang, ...
Journal of medicinal chemistry 46 (20), 4236-4239, 2003
2942003
Identification of hepatitis C virus NS5A inhibitors
JA Lemm, D O'Boyle, M Liu, PT Nower, R Colonno, MS Deshpande, ...
Journal of virology 84 (1), 482-491, 2010
2562010
ללא שם
WO Patent 2008021927:A2, 0
234*
Preclinical profile and characterization of the hepatitis C virus NS3 protease inhibitor asunaprevir (BMS-650032)
F McPhee, AK Sheaffer, J Friborg, D Hernandez, P Falk, G Zhai, S Levine, ...
Antimicrobial agents and chemotherapy 56 (10), 5387-5396, 2012
2312012
Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions
Q Guo, HT Ho, I Dicker, L Fan, N Zhou, J Friborg, T Wang, BV McAuliffe, ...
Journal of virology 77 (19), 10528-10536, 2003
2252003
Azetidin-2-one derivatives as inhibitors of thrombin
WT Han, AK Trehan, JJK Wright, ME Federici, SM Seiler, NA Meanwell
Bioorganic & Medicinal Chemistry 3 (8), 1123-1143, 1995
2231995
Improving drug design: an update on recent applications of efficiency metrics, strategies for replacing problematic elements, and compounds in nontraditional drug space
NA Meanwell
Chemical Research in Toxicology 29 (4), 564-616, 2016
2182016
Applications of fluorine-containing amino acids for drug design
H Mei, J Han, KD Klika, K Izawa, T Sato, NA Meanwell, VA Soloshonok
European journal of medicinal chemistry 186, 111826, 2020
2132020
Effects of channel modulators on cloned large-conductance calcium-activated potassium channels.
VK Gribkoff, JT Lum-Ragan, CG Boissard, DJ Post-Munson, NA Meanwell, ...
Molecular pharmacology 50 (1), 206-217, 1996
2041996
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מאמרים 1–20