| The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics JO Lundberg, E Weitzberg, MT Gladwin Nature reviews Drug discovery 7 (2), 156-167, 2008 | 3200 | 2008 |
| Updated clinical classification of pulmonary hypertension G Simonneau, IM Robbins, M Beghetti, RN Channick, M Delcroix, ... Journal of the American college of cardiology 54 (1_Supplement_S), S43-S54, 2009 | 3131 | 2009 |
| Sickle-cell disease DC Rees, TN Williams, MT Gladwin The Lancet 376 (9757), 2018-2031, 2010 | 2953 | 2010 |
| Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation K Cosby, KS Partovi, JH Crawford, RP Patel, CD Reiter, S Martyr, ... Nature medicine 9 (12), 1498-1505, 2003 | 2179 | 2003 |
| The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease RP Rother, L Bell, P Hillmen, MT Gladwin Jama 293 (13), 1653-1662, 2005 | 1930 | 2005 |
| Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program D Taliun, DN Harris, MD Kessler, J Carlson, ZA Szpiech, R Torres, ... Nature 590 (7845), 290-299, 2021 | 1805 | 2021 |
| Pulmonary hypertension as a risk factor for death in patients with sickle cell disease MT Gladwin, V Sachdev, ML Jison, Y Shizukuda, JF Plehn, K Minter, ... New England Journal of Medicine 350 (9), 886-895, 2004 | 1579 | 2004 |
| Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure NF Voelkel, RA Quaife, LA Leinwand, RJ Barst, MD McGoon, ... Circulation 114 (17), 1883-1891, 2006 | 1518 | 2006 |
| Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease CD Reiter, X Wang, JE Tanus-Santos, N Hogg, RO Cannon, ... Nature medicine 8 (12), 1383-1389, 2002 | 1517 | 2002 |
| Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes GJ Kato, MT Gladwin, MH Steinberg Blood reviews 21 (1), 37-47, 2007 | 1037 | 2007 |
| Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease CR Morris, GJ Kato, M Poljakovic, X Wang, WC Blackwelder, V Sachdev, ... Jama 294 (1), 81-90, 2005 | 896 | 2005 |
| Carbon monoxide poisoning: pathogenesis, management, and future directions of therapy JJ Rose, L Wang, Q Xu, CF McTiernan, S Shiva, J Tejero, MT Gladwin American journal of respiratory and critical care medicine 195 (5), 596-606, 2017 | 846 | 2017 |
| Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver MR Duranski, JJM Greer, A Dejam, S Jaganmohan, N Hogg, W Langston, ... The Journal of clinical investigation 115 (5), 1232-1240, 2005 | 824 | 2005 |
| Nitrate and nitrite in biology, nutrition and therapeutics JO Lundberg, MT Gladwin, A Ahluwalia, N Benjamin, NS Bryan, A Butler, ... Nature chemical biology 5 (12), 865-869, 2009 | 804 | 2009 |
| Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell … GJ Kato, V McGowan, RF Machado, JA Little, J Taylor, CR Morris, ... Blood 107 (6), 2279-2285, 2006 | 776 | 2006 |
| Pathophysiology of sickle cell disease P Sundd, MT Gladwin, EM Novelli Annual review of pathology: mechanisms of disease 14 (1), 263-292, 2019 | 767 | 2019 |
| Intravascular hemolysis and the pathophysiology of sickle cell disease GJ Kato, MH Steinberg, MT Gladwin The Journal of clinical investigation 127 (3), 750-760, 2017 | 751 | 2017 |
| The emerging biology of the nitrite anion MT Gladwin, AN Schechter, DB Kim-Shapiro, RP Patel, N Hogg, S Shiva, ... Nature chemical biology 1 (6), 308-314, 2005 | 723 | 2005 |
| Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration S Shiva, Z Huang, R Grubina, J Sun, LA Ringwood, PH MacArthur, X Xu, ... Circulation research 100 (5), 654-661, 2007 | 719 | 2007 |
| Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion C Donadee, NJH Raat, T Kanias, J Tejero, JS Lee, EE Kelley, X Zhao, ... Circulation 124 (4), 465-476, 2011 | 676 | 2011 |