| A simple method for site-directed mutagenesis using the polymerase chain reaction A Hemsley, N Arnheim, MD Toney, G Cortopassi, DJ Galas Nucleic acids research 17 (16), 6545-6551, 1989 | 836 | 1989 |
| Reaction specificity in pyridoxal phosphate enzymes MD Toney Archives of biochemistry and biophysics 433 (1), 279-287, 2005 | 363 | 2005 |
| Direct Brønsted analysis of the restoration of activity to a mutant enzyme by exogenous amines MD Toney, JF Kirsch Science 243 (4897), 1485-1488, 1989 | 289 | 1989 |
| Serine racemase modulates intracellular D-serine levels through an α, β-elimination activity VN Foltyn, I Bendikov, J De Miranda, R Panizzutti, E Dumin, M Shleper, ... Journal of Biological Chemistry 280 (3), 1754-1763, 2005 | 255 | 2005 |
| Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites MD Toney, E Hohenester, SW Cowan, JN Jansonius Science 261 (5122), 756-759, 1993 | 242 | 1993 |
| Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide–polyketide antitumor drug bleomycin C Sánchez, L Du, DJ Edwards, MD Toney, B Shen Chemistry & biology 8 (7), 725-738, 2001 | 219 | 2001 |
| Controlling reaction specificity in pyridoxal phosphate enzymes MD Toney Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1814 (11), 1407-1418, 2011 | 196 | 2011 |
| Evidence for a two-base mechanism involving tyrosine-265 from arginine-219 mutants of alanine racemase S Sun, MD Toney Biochemistry 38 (13), 4058-4065, 1999 | 173 | 1999 |
| A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis SD Christenson, W Liu, MD Toney, B Shen Journal of the American Chemical Society 125 (20), 6062-6063, 2003 | 148 | 2003 |
| Aspartate aminotransferase: an old dog teaches new tricks MD Toney Archives of biochemistry and biophysics 544, 119-127, 2014 | 145 | 2014 |
| NMR studies of solvent-assisted proton transfer in a biologically relevant Schiff base: Toward a distinction of geometric and equilibrium H-bond isotope effects S Sharif, GS Denisov, MD Toney, HH Limbach Journal of the American Chemical Society 128 (10), 3375-3387, 2006 | 137 | 2006 |
| Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase MD Toney, E Hohenester, JW Keller, JN Jansonius Journal of molecular biology 245 (2), 151-179, 1995 | 136 | 1995 |
| Coupling of functional hydrogen bonds in pyridoxal-5 ‘-phosphate− Enzyme model systems observed by solid-state NMR spectroscopy S Sharif, D Schagen, MD Toney, HH Limbach Journal of the American Chemical Society 129 (14), 4440-4455, 2007 | 128 | 2007 |
| Lysine 258 in aspartate aminotransferase: Enforcer of the Circe effect for amino acid substrates and the general-base catalyst for the 1, 3-prototropic shift MD Toney, JF Kirsch Biochemistry 32 (6), 1471-1479, 1993 | 125 | 1993 |
| Crystal structures of unbound and aminooxyacetate-bound Escherichia coli γ-aminobutyrate aminotransferase W Liu, PE Peterson, RJ Carter, X Zhou, JA Langston, AJ Fisher, ... Biochemistry 43 (34), 10896-10905, 2004 | 123 | 2004 |
| 2.8-. ANG.-resolution crystal structure of an active-site mutant of aspartate aminotransferase from Escherichia coli DL Smith, SC Almo, MD Toney, D Ringe Biochemistry 28 (20), 8161-8167, 1989 | 121 | 1989 |
| Aminophosphonate Inhibitors of Dialkylglycine Decarboxylase: Structural Basis for Slow Binding Inhibition, W Liu, CJ Rogers, AJ Fisher, MD Toney Biochemistry 41 (41), 12320-12328, 2002 | 113 | 2002 |
| Conservation of mechanism in three chorismate-utilizing enzymes Z He, KD Stigers Lavoie, PA Bartlett, MD Toney Journal of the American Chemical Society 126 (8), 2378-2385, 2004 | 111 | 2004 |
| NMR Studies of Coupled Low-and High-Barrier Hydrogen Bonds in Pyridoxal-5 ‘-phosphate Model Systems in Polar Solution S Sharif, GS Denisov, MD Toney, HH Limbach Journal of the American Chemical Society 129 (19), 6313-6327, 2007 | 108 | 2007 |
| Crystal structure of true enzymic reaction intermediates: aspartate and glutamate ketimines in aspartate aminotransferase VN Malashkevich, MD Toney, JN Jansonius Biochemistry 32 (49), 13451-13462, 1993 | 96 | 1993 |
