| Diffusible, nonfibrillar ligands derived from Aβ1–42 are potent central nervous system neurotoxins MP Lambert, AK Barlow, BA Chromy, C Edwards, R Freed, M Liosatos, ... Proceedings of the National Academy of Sciences 95 (11), 6448-6453, 1998 | 4694 | 1998 |
| Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease PN Lacor, MC Buniel, PW Furlow, AS Clemente, PT Velasco, M Wood, ... Journal of Neuroscience 27 (4), 796-807, 2007 | 1569 | 2007 |
| Alzheimer's disease-affected brain: presence of oligomeric Aβ ligands (ADDLs) suggests a molecular basis for reversible memory loss Y Gong, L Chang, KL Viola, PN Lacor, MP Lambert, CE Finch, GA Krafft, ... Proceedings of the National Academy of Sciences 100 (18), 10417-10422, 2003 | 1447 | 2003 |
| Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? WL Klein, GA Krafft, CE Finch Trends in neurosciences 24 (4), 219-224, 2001 | 1431 | 2001 |
| Synaptic targeting by Alzheimer's-related amyloid β oligomers PN Lacor, MC Buniel, L Chang, SJ Fernandez, Y Gong, KL Viola, ... Journal of Neuroscience 24 (45), 10191-10200, 2004 | 1273 | 2004 |
| Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor AJ Haes, L Chang, WL Klein, RP Van Duyne Journal of the American Chemical Society 127 (7), 2264-2271, 2005 | 1145 | 2005 |
| Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine FG De Felice, PT Velasco, MP Lambert, K Viola, SJ Fernandez, ... Journal of Biological Chemistry 282 (15), 11590-11601, 2007 | 1109 | 2007 |
| Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease DG Georganopoulou, L Chang, JM Nam, CS Thaxton, EJ Mufson, ... Proceedings of the National Academy of Sciences 102 (7), 2273-2276, 2005 | 1105 | 2005 |
| A localized surface plasmon resonance biosensor: First steps toward an assay for Alzheimer's disease AJ Haes, WP Hall, L Chang, WL Klein, RP Van Duyne Nano letters 4 (6), 1029-1034, 2004 | 952 | 2004 |
| An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers TR Bomfim, L Forny-Germano, LB Sathler, J Brito-Moreira, JC Houzel, ... The Journal of clinical investigation 122 (4), 1339-1353, 2012 | 944 | 2012 |
| Modeling Alzheimer’s disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness T Kondo, M Asai, K Tsukita, Y Kutoku, Y Ohsawa, Y Sunada, K Imamura, ... Cell stem cell 12 (4), 487-496, 2013 | 899 | 2013 |
| Aβ toxicity in Alzheimer’s disease: globular oligomers (ADDLs) as new vaccine and drug targets WL Klein Neurochemistry international 41 (5), 345-352, 2002 | 890 | 2002 |
| The amyloid-β oligomer hypothesis: beginning of the third decade EN Cline, MA Bicca, KL Viola, WL Klein Journal of Alzheimer's Disease 64 (s1), S567-S610, 2018 | 830 | 2018 |
| Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers FG De Felice, MNN Vieira, TR Bomfim, H Decker, PT Velasco, ... Proceedings of the National Academy of Sciences 106 (6), 1971-1976, 2009 | 794 | 2009 |
| Soluble oligomers of β amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus HW Wang, JF Pasternak, H Kuo, H Ristic, MP Lambert, B Chromy, ... Brain research 924 (2), 133-140, 2002 | 772 | 2002 |
| Amyloid beta oligomers induce impairment of neuronal insulin receptors WQ Zhao, FG De Felice, S Fernandez, H Chen, MP Lambert, MJ Quon, ... The FASEB Journal 22 (1), 246-260, 2008 | 746 | 2008 |
| Self-assembly of Aβ1-42 into globular neurotoxins BA Chromy, RJ Nowak, MP Lambert, KL Viola, L Chang, PT Velasco, ... Biochemistry 42 (44), 12749-12760, 2003 | 707 | 2003 |
| Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis KL Viola, WL Klein Acta neuropathologica 129, 183-206, 2015 | 692 | 2015 |
| Cholesterol modulates α-secretase cleavage of amyloid precursor protein S Bodovitz, WL Klein Journal of Biological Chemistry 271 (8), 4436-4440, 1996 | 630 | 1996 |
| Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers FG De Felice, D Wu, MP Lambert, SJ Fernandez, PT Velasco, PN Lacor, ... Neurobiology of aging 29 (9), 1334-1347, 2008 | 628 | 2008 |
