| Proteasome inhibitors: an expanding army attacking a unique target AF Kisselev, WA van der Linden, HS Overkleeft Chemistry & biology 19 (1), 99-115, 2012 | 670 | 2012 |
| A novel active site‐directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 A Borodovsky, BM Kessler, R Casagrande, HS Overkleeft, KD Wilkinson, ... The EMBO journal, 2001 | 591 | 2001 |
| Thioglycosides in sequential glycosylation strategies JDC Codée, REJN Litjens, LJ van den Bos, HS Overkleeft, ... Chemical Society Reviews 34 (9), 769-782, 2005 | 428 | 2005 |
| Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1 C Kuijl, NDL Savage, M Marsman, AW Tuin, L Janssen, DA Egan, ... Nature 450 (7170), 725-730, 2007 | 382 | 2007 |
| Glycosphingolipids—nature, function, and pharmacological modulation T Wennekes, RJ van den Berg, RG Boot, GA van der Marel, HS Overkleeft, ... Angewandte Chemie International Edition 48 (47), 8848-8869, 2009 | 362 | 2009 |
| Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity JM Aerts, R Ottenhoff, AS Powlson, A Grefhorst, M Van Eijk, ... Diabetes 56 (5), 1341-1349, 2007 | 342 | 2007 |
| Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474 ACM van Esbroeck, APA Janssen, AB Cognetta III, D Ogasawara, ... Science 356 (6342), 1084-1087, 2017 | 335 | 2017 |
| Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response N Dekker, L van Dussen, CEM Hollak, H Overkleeft, S Scheij, ... Blood, The Journal of the American Society of Hematology 118 (16), e118-e127, 2011 | 308 | 2011 |
| Ultrasensitive in situ visualization of active glucocerebrosidase molecules MD Witte, WW Kallemeijn, J Aten, KY Li, A Strijland, WE Donker-Koopman, ... Nature chemical biology 6 (12), 907-913, 2010 | 297 | 2010 |
| Ph2SO/Tf2O: a Powerful Promotor System in Chemoselective Glycosylations Using Thioglycosides JDC Codée, REJN Litjens, R den Heeten, HS Overkleeft, JH van Boom, ... Organic letters 5 (9), 1519-1522, 2003 | 289 | 2003 |
| Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation AM Lennon-Duménil, AH Bakker, R Maehr, E Fiebiger, HS Overkleeft, ... The Journal of experimental medicine 196 (4), 529-540, 2002 | 277 | 2002 |
| Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway M Altun, HC Besche, HS Overkleeft, R Piccirillo, MJ Edelmann, ... Journal of Biological Chemistry 285 (51), 39597-39608, 2010 | 266 | 2010 |
| Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase HS Overkleeft, GH Renkema, J Neele, P Vianello, IO Hung, A Strijland, ... Journal of Biological Chemistry 273 (41), 26522-26527, 1998 | 266 | 1998 |
| The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites AF Kisselev, M Garcia-Calvo, HS Overkleeft, E Peterson, MW Pennington, ... Journal of Biological Chemistry 278 (38), 35869-35877, 2003 | 260 | 2003 |
| Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division JT Chang, ML Ciocca, I Kinjyo, VR Palanivel, CE McClurkin, CS DeJong, ... Immunity 34 (4), 492-504, 2011 | 249 | 2011 |
| Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses KC Lehmann, A Gulyaeva, JC Zevenhoven-Dobbe, GMC Janssen, ... Nucleic acids research 43 (17), 8416-8434, 2015 | 242 | 2015 |
| Identification of the non-lysosomal glucosylceramidase as β-glucosidase 2 RG Boot, M Verhoek, W Donker-Koopman, A Strijland, J van Marle, ... Journal of Biological Chemistry 282 (2), 1305-1312, 2007 | 237 | 2007 |
| A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo M Verdoes, BI Florea, V Menendez-Benito, CJ Maynard, MD Witte, ... Chemistry & biology 13 (11), 1217-1226, 2006 | 237 | 2006 |
| Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells S Khan, MS Bijker, JJ Weterings, HJ Tanke, GJ Adema, T van Hall, ... Journal of Biological Chemistry 282 (29), 21145-21159, 2007 | 225 | 2007 |
| Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy H Ovaa, PF Van Swieten, BM Kessler, MA Leeuwenburgh, E Fiebiger, ... Angewandte Chemie (International ed. in English) 42 (31), 3626-3629, 2003 | 219 | 2003 |
