| Structural analysis of the sialyltransferase CstII from Campylobacter jejuni in complex with a substrate analog CPC Chiu, AG Watts, LL Lairson, M Gilbert, D Lim, WW Wakarchuk, ... Nature structural & molecular biology 11 (2), 163-170, 2004 | 287 | 2004 |
| Trypanosoma cruzi Trans-sialidase Operates through a Covalent Sialyl−Enzyme Intermediate: Tyrosine Is the Catalytic Nucleophile AG Watts, I Damager, ML Amaya, A Buschiazzo, P Alzari, AC Frasch, ... Journal of the American Chemical Society 125 (25), 7532-7533, 2003 | 287 | 2003 |
| Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase MF Amaya, AG Watts, I Damager, A Wehenkel, T Nguyen, A Buschiazzo, ... Structure 12 (5), 775-784, 2004 | 273 | 2004 |
| Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity JH Kim, R Resende, T Wennekes, HM Chen, N Bance, S Buchini, ... Science 340 (6128), 71-75, 2013 | 226 | 2013 |
| The structure of Clostridium perfringens NanI sialidase and its catalytic intermediates SL Newstead, JA Potter, JC Wilson, G Xu, CH Chien, AG Watts, ... Journal of Biological Chemistry 283 (14), 9080-9088, 2008 | 162 | 2008 |
| A key role for redox signaling in rapid P2X7 receptor-induced IL-1β processing in human monocytes J Hewinson, SF Moore, C Glover, AG Watts, AB MacKenzie The Journal of Immunology 180 (12), 8410-8420, 2008 | 148 | 2008 |
| Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase AG Watts, P Oppezzo, SG Withers, PM Alzari, A Buschiazzo Journal of Biological Chemistry 281 (7), 4149-4155, 2006 | 116 | 2006 |
| Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae A Muller, E Severi, C Mulligan, AG Watts, DJ Kelly, KS Wilson, ... Journal of Biological Chemistry 281 (31), 22212-22222, 2006 | 115 | 2006 |
| Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis LL Lairson, AG Watts, WW Wakarchuk, SG Withers Nature Chemical Biology 2 (12), 724-728, 2006 | 83 | 2006 |
| Kinetic and Mechanistic Analysis of Trypanosoma cruzi Trans-Sialidase Reveals a Classical Ping-Pong Mechanism with Acid/Base Catalysis I Damager, S Buchini, MF Amaya, A Buschiazzo, P Alzari, AC Frasch, ... Biochemistry 47 (11), 3507-3512, 2008 | 81 | 2008 |
| The synthesis of some mechanistic probes for sialic acid processing enzymes and the labeling of a sialidase from Trypanosoma rangeli AG Watts, SG Withers Canadian journal of chemistry 82 (11), 1581-1588, 2004 | 70 | 2004 |
| Characterization of reactions between water-soluble trialkylphosphines and thiol alkylating reagents: implications for protein-conjugation reactions T Kantner, AG Watts Bioconjugate Chemistry 27 (10), 2400-2406, 2016 | 55 | 2016 |
| The Aspergillus fumigatus sialidase is a 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase (KDNase): structural and mechanistic insights JC Telford, JHF Yeung, G Xu, MJ Kiefel, AG Watts, S Hader, J Chan, ... Journal of Biological Chemistry 286 (12), 10783-10792, 2011 | 48 | 2011 |
| Tripartite ATP-independent periplasmic (TRAP) transporters use an arginine-mediated selectivity filter for high affinity substrate binding M Fischer, AP Hopkins, E Severi, J Hawkhead, D Bawdon, AG Watts, ... Journal of Biological Chemistry 290 (45), 27113-27123, 2015 | 43 | 2015 |
| High PD-1/PD-L1 checkpoint interaction infers tumor selection and therapeutic sensitivity to anti-PD-1/PD-L1 treatment L Sánchez-Magraner, J Miles, CL Baker, CJ Applebee, DJ Lee, ... Cancer Research 80 (19), 4244-4257, 2020 | 42 | 2020 |
| 2, 3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals S Withers, AG Watts, JH Kim, T Wennekes US Patent 8,815,941, 2014 | 39 | 2014 |
| Neuraminidase inhibitor compounds, compositions and methods for the use thereof in anti-viral treatments S Withers, AG Watts, JH Kim, T Wennekes US Patent 8,907,111, 2014 | 37 | 2014 |
| 2, 3-fluorinated glycosides as neuraminidase inhibitors and their use as anti-virals S Withers, AG Watts, JH Kim, T Wennekes US Patent 9,221,859, 2015 | 35 | 2015 |
| Neuraminidase inhibitor compounds, compositions and methods for the use thereof in anti-viral treatments S Withers, AG Watts, JH Kim, T Wennekes US Patent 9,382,284, 2016 | 34 | 2016 |
| In situ quenching of trialkylphosphine reducing agents using water-soluble PEG-azides improves maleimide conjugation to proteins T Kantner, B Alkhawaja, AG Watts ACS omega 2 (9), 5785-5791, 2017 | 30 | 2017 |
