| Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53 D Martinez-Zapien, FX Ruiz, J Poirson, A Mitschler, J Ramirez, A Forster, ... Nature 529 (7587), 541-545, 2016 | 472 | 2016 |
| Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase MP Blakeley, F Ruiz, R Cachau, I Hazemann, F Meilleur, A Mitschler, ... Proceedings of the National Academy of Sciences 105 (6), 1844-1848, 2008 | 97 | 2008 |
| Modulation of aldose reductase inhibition by halogen bond tuning J Fanfrlik, M Kolar, M Kamlar, D Hurny, FX Ruiz, A Cousido-Siah, ... ACS Chemical Biology 8 (11), 2484-2492, 2013 | 96 | 2013 |
| Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of … MC Van Zandt, DL Whitehouse, A Golebiowski, MK Ji, M Zhang, ... Journal of medicinal chemistry 56 (6), 2568-2580, 2013 | 94 | 2013 |
| Neutron structure of type‐III antifreeze protein allows the reconstruction of AFP–ice interface EI Howard, MP Blakeley, M Haertlein, IP Haertlein, A Mitschler, SJ Fisher, ... Journal of Molecular Recognition 24 (4), 724-732, 2011 | 94 | 2011 |
| Iminosugar‐Cyclopeptoid Conjugates Raise Multivalent Effect in Glycosidase Inhibition at Unprecedented High Levels ML Lepage, JP Schneider, A Bodlenner, A Meli, F De Riccardis, M Schmitt, ... Chemistry–A European Journal 22 (15), 5151-5155, 2016 | 63 | 2016 |
| Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant … T Petrova, H Steuber, I Hazemann, A Cousido-Siah, A Mitschler, R Chung, ... Journal of medicinal chemistry 48 (18), 5659-5665, 2005 | 61 | 2005 |
| A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth M Celegato, L Messa, L Goracci, B Mercorelli, C Bertagnin, F Spyrakis, ... Cancer Letters 470, 115-125, 2020 | 57 | 2020 |
| Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition E Howard, A Cousido‐Siah, ML Lepage, JP Schneider, A Bodlenner, ... Angewandte Chemie International Edition 57 (27), 8002-8006, 2018 | 53 | 2018 |
| The effect of halogen-to-hydrogen bond substitution on human aldose reductase inhibition J Fanfrlik, FX Ruiz, A Kadlcikova, J Rezac, A Cousido-Siah, A Mitschler, ... ACS chemical biology 10 (7), 1637-1642, 2015 | 50 | 2015 |
| Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10 FAC Klein, G Zeder-Lutz, A Cousido-Siah, A Mitschler, A Katz, P Eberling, ... Human molecular genetics 22 (20), 4215-4223, 2013 | 48 | 2013 |
| Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction A Golebiowski, D Whitehouse, RP Beckett, M Van Zandt, MK Ji, TR Ryder, ... Bioorganic & medicinal chemistry letters 23 (17), 4837-4841, 2013 | 48 | 2013 |
| High-resolution neutron and X-ray diffraction room-temperature studies of an H-FABP–oleic acid complex: study of the internal water cluster and ligand binding by a transferred … EI Howard, B Guillot, MP Blakeley, M Haertlein, M Moulin, A Mitschler, ... IUCrJ 3 (2), 115-126, 2016 | 44 | 2016 |
| 2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors A Golebiowski, RP Beckett, M Van Zandt, MK Ji, D Whitehouse, TR Ryder, ... Bioorganic & medicinal chemistry letters 23 (7), 2027-2030, 2013 | 43 | 2013 |
| X-ray crystal structure of the full length human chitotriosidase (CHIT1) reveals features of its chitin binding domain F Fadel, Y Zhao, A Cousido-Siah, FX Ruiz, A Mitschler, A Podjarny PloS one 11 (4), e0154190, 2016 | 41 | 2016 |
| Dual specificity PDZ-and 14-3-3-binding motifs: a structural and interactomics study G Gogl, P Jane, C Caillet-Saguy, C Kostmann, G Bich, A Cousido-Siah, ... Structure 28 (7), 747-759. e3, 2020 | 39 | 2020 |
| Targeting acidic mammalian chitinase is effective in animal model of asthma M Mazur, J Olczak, S Olejniczak, R Koralewski, W Czestkowski, ... Journal of Medicinal Chemistry 61 (3), 695-710, 2018 | 33 | 2018 |
| New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM F Fadel, Y Zhao, R Cachau, A Cousido-Siah, FX Ruiz, K Harlos, ... Acta Crystallographica Section D: Biological Crystallography 71 (7), 1455-1470, 2015 | 33 | 2015 |
| Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and … A Cousido-Siah, FX Ruiz, A Mitschler, S Porté, ÁR De Lera, MJ Martin, ... Acta Crystallographica Section D: Biological Crystallography 70 (3), 889-903, 2014 | 32 | 2014 |
| Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II MC Van Zandt, GE Jagdmann, DL Whitehouse, M Ji, J Savoy, O Potapova, ... Journal of medicinal chemistry 62 (17), 8164-8177, 2019 | 30 | 2019 |
