| Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene HWD Matthes, R Maldonado, F Simonin, O Valverde, S Slowe, I Kitchen, ... Nature 383 (6603), 819-823, 1996 | 2139 | 1996 |
| Mice deficient for δ-and μ-opioid receptors exhibit opposing alterations of emotional responses D Filliol, S Ghozland, J Chluba, M Martin, HWD Matthes, F Simonin, ... Nature genetics 25 (2), 195-200, 2000 | 801 | 2000 |
| Involvement of the endocannabinoid system in drug addiction R Maldonado, O Valverde, F Berrendero Trends in neurosciences 29 (4), 225-232, 2006 | 701 | 2006 |
| Involvement of the extracellular signal-regulated kinase cascade for cocaine-rewarding properties E Valjent, JC Corvol, C Pagès, MJ Besson, R Maldonado, J Caboche Journal of Neuroscience 20 (23), 8701-8709, 2000 | 634 | 2000 |
| Involvement of CB1 cannabinoid receptors in emotional behaviour M Martin, C Ledent, M Parmentier, R Maldonado, O Valverde Psychopharmacology 159, 379-387, 2002 | 610 | 2002 |
| Absence of opiate rewarding effects in mice lacking dopamine D2 receptors R Maldonado, A Saiardi, O Valverde, TA Samad, BP Roques, E Borrelli Nature 388 (6642), 586-589, 1997 | 599 | 1997 |
| Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory C Mazzucchelli, C Vantaggiato, A Ciamei, S Fasano, P Pakhotin, ... Neuron 34 (5), 807-820, 2002 | 584 | 2002 |
| The endocannabinoid system in guarding against fear, anxiety and stress B Lutz, G Marsicano, R Maldonado, CJ Hillard Nature Reviews Neuroscience 16 (12), 705-718, 2015 | 520 | 2015 |
| Neural substrates of opiate withdrawal GF Koob, R Maldonado, L Stinus Trends in neurosciences 15 (5), 186-191, 1992 | 516 | 1992 |
| Disruption of the κ-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ-agonist U-50,488 H and … F Simonin, O Valverde, C Smadja, S Slowe, I Kitchen, A Dierich, ... The EMBO journal 17 (4), 886-897, 1998 | 511 | 1998 |
| Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice J Planagumà, F Leypoldt, F Mannara, J Gutiérrez-Cuesta, E Martín-García, ... Brain 138 (1), 94-109, 2015 | 493 | 2015 |
| Role of different brain structures in the expression of the physical morphine withdrawal syndrome. R Maldonado, L Stinus, LH Gold, GF Koob Journal of Pharmacology and Experimental Therapeutics 261 (2), 669-677, 1992 | 485 | 1992 |
| Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling E Puighermanal, G Marsicano, A Busquets-Garcia, B Lutz, R Maldonado, ... Nature neuroscience 12 (9), 1152-1158, 2009 | 471 | 2009 |
| Functional interaction between opioid and cannabinoid receptors in drug self-administration M Navarro, MRA Carrera, W Fratta, O Valverde, G Cossu, L Fattore, ... Journal of Neuroscience 21 (14), 5344-5350, 2001 | 435 | 2001 |
| Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB R Maldonado, JA Blendy, E Tzavara, P Gass, BP Roques, J Hanoune, ... Science 273 (5275), 657-659, 1996 | 384 | 1996 |
| Behavioural and biochemical evidence for interactions between Δ9‐tetrahydrocannabinol and nicotine E Valjent, JM Mitchell, MJ Besson, J Caboche, R Maldonado British journal of pharmacology 135 (2), 564-578, 2002 | 361 | 2002 |
| Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses A Busquets-Garcia, E Puighermanal, A Pastor, R De La Torre, ... Biological psychiatry 70 (5), 479-486, 2011 | 336 | 2011 |
| Motivational effects of cannabinoids are mediated by μ-opioid and κ-opioid receptors S Ghozland, HWD Matthes, F Simonin, D Filliol, BL Kieffer, R Maldonado Journal of Neuroscience 22 (3), 1146-1154, 2002 | 328 | 2002 |
| Pregnenolone can protect the brain from cannabis intoxication M Vallée, S Vitiello, L Bellocchio, E Hébert-Chatelain, S Monlezun, ... science 343 (6166), 94-98, 2014 | 327 | 2014 |
| The endogenous opioid system: a common substrate in drug addiction JM Trigo, E Martin-García, F Berrendero, P Robledo, R Maldonado Drug and alcohol dependence 108 (3), 183-194, 2010 | 297 | 2010 |
