| Aza Diels-Alder reactions in aqueous solution: cyclocondensation of dienes with simple iminium salts generated under Mannich conditions SD Larsen, PA Grieco Journal of the American Chemical Society 107 (6), 1768-1769, 1985 | 370 | 1985 |
| X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases YM Báez-Santos, SJ Barraza, MW Wilson, MP Agius, AM Mielech, ... Journal of Medicinal Chemistry 57 (6), 2393-2412, 2014 | 236 | 2014 |
| Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β–induced fibrogenesis in human colonic myofibroblasts LA Johnson, ES Rodansky, AJ Haak, SD Larsen, RR Neubig, ... Inflammatory bowel diseases 20 (1), 154-165, 2014 | 211 | 2014 |
| Redox modification of nuclear actin by MICAL-2 regulates SRF signaling MR Lundquist, AJ Storaska, TC Liu, SD Larsen, T Evans, RR Neubig, ... Cell 156 (3), 563-576, 2014 | 197 | 2014 |
| Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis TH Sisson, IO Ajayi, N Subbotina, AE Dodi, ES Rodansky, LN Chibucos, ... The American journal of pathology 185 (4), 969-986, 2015 | 177 | 2015 |
| Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence H Zheng, CJ Colvin, BK Johnson, PD Kirchhoff, M Wilson, ... Nature chemical biology 13 (2), 218-225, 2017 | 166 | 2017 |
| Investigation of potential bioisosteric replacements for the carboxyl groups of peptidomimetic inhibitors of protein tyrosine phosphatase 1B: identification of a tetrazole … C Liljebris, SD Larsen, D Ogg, BJ Palazuk, JE Bleasdale Journal of medicinal chemistry 45 (9), 1785-1798, 2002 | 161 | 2002 |
| Structure of methylguanidinium dihydrogen orthophosphate. Model compound for arginine-phosphate hydrogen bonding FA Cotton, VW Day, EE Hazen, S Larsen Journal of the American Chemical Society 95 (15), 4834-4840, 1973 | 158 | 1973 |
| A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells I Chefetz, E Grimley, K Yang, L Hong, EV Vinogradova, R Suciu, ... Cell reports 26 (11), 3061-3075. e6, 2019 | 134 | 2019 |
| Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action JE Bleasdale, D Ogg, BJ Palazuk, CS Jacob, ML Swanson, XY Wang, ... Biochemistry 40 (19), 5642-5654, 2001 | 125 | 2001 |
| Reactions of allylsilanes with simple iminium salts in water: A facile route to piperidines via a aminomethano desilylation-cyclization process SD Larsen, PA Grieco, WF Fobare Journal of the American Chemical Society 108 (12), 3512-3513, 1986 | 117 | 1986 |
| Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor–regulated gene transcription prevent fibrosis in a murine … AJ Haak, PS Tsou, MA Amin, JH Ruth, P Campbell, DA Fox, D Khanna, ... Journal of Pharmacology and Experimental Therapeutics 349 (3), 480-486, 2014 | 110 | 2014 |
| Aza Diels-Alder reactions in water: cyclocondensation of C-acyl iminium ions with cyclopentadiene PA Grieco, SD Larsen, WF Fobare Tetrahedron letters 27 (18), 1975-1978, 1986 | 110 | 1986 |
| Nonstabilized imidate ylides by the desilylation method: a route to the pyrrolizidine alkaloids retronecine and indicine E Vedejs, S Larsen, FG West The Journal of Organic Chemistry 50 (12), 2170-2174, 1985 | 104 | 1985 |
| Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent SD Larsen, MA Connell, MM Cudahy, BR Evans, PD May, MD Meglasson, ... Journal of medicinal chemistry 44 (8), 1217-1230, 2001 | 100 | 2001 |
| Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B SD Larsen, T Barf, C Liljebris, PD May, D Ogg, TJ O'Sullivan, BJ Palazuk, ... Journal of medicinal chemistry 45 (3), 598-622, 2002 | 98 | 2002 |
| Novel Inhibitors of Staphylococcus aureus Virulence Gene Expression and Biofilm Formation Y Ma, Y Xu, BD Yestrepsky, RJ Sorenson, M Chen, SD Larsen, H Sun Public Library of Science 7 (10), e47255, 2012 | 97 | 2012 |
| Optimization of novel nipecotic bis (amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents JL Bell, AJ Haak, SM Wade, PD Kirchhoff, RR Neubig, SD Larsen Bioorganic & medicinal chemistry letters 23 (13), 3826-3832, 2013 | 90 | 2013 |
| Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors JA Pfefferkorn, Y Song, KL Sun, SR Miller, BK Trivedi, C Choi, ... Bioorganic & medicinal chemistry letters 17 (16), 4538-4544, 2007 | 86 | 2007 |
| Design, synthesis and prostate cancer cell-based studies of analogs of the Rho/MKL1 transcriptional pathway inhibitor, CCG-1423 CR Evelyn, JL Bell, JG Ryu, SM Wade, A Kocab, NL Harzdorf, ... Bioorganic & medicinal chemistry letters 20 (2), 665-672, 2010 | 85 | 2010 |