John Asara

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Lewis CantleyDana Farber Cancer Center and Harvard Medical SchoolEmail verificata su med.cornell.edu
Costas LyssiotisProfessor of Physiology, University of MichiganEmail verificata su lyssiotis.com
Brendan D. ManningHarvard UniversityEmail verificata su hsph.harvard.edu
Jason LocasaleDuke UniversityEmail verificata su alum.mit.edu
Wenyi WeiProfessor, Dept. of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical SchoolEmail verificata su bidmc.harvard.edu
William S. LaneHarvard University, MSPRL Director (Mass Spectrometry & Proteomics Resource Lab)Email verificata su harvard.edu
Issam Ben-SahraNorthwestern UniversityEmail verificata su northwestern.edu
Pier Paolo PandolfiDirector, Cancer Center and Cancer Research Institute, Beth Israel Deaconess Medical CenterEmail verificata su bidmc.harvard.edu
Alex TokerEmail verificata su bidmc.harvard.edu
John BlenisProfessor of Pharmacology, Weill Cornell MedicineEmail verificata su med.cornell.edu
Reuben ShawThe Salk Institute of Biological StudiesEmail verificata su salk.edu
Gerburg WulfAssociate Professor in Medicine, Harvard Medical SchoolEmail verificata su bidmc.harvard.edu
Bin ZhengCedars-Sinai Medical CenterEmail verificata su cshs.org
Shyh-Chang, NgInstitute of Zoology (IOZ), Institute of Stem cells & Regeneration (ISCR), UCAS, CASEmail verificata su ioz.ac.cn
David J. KwiatkowskiProfessor of Medicine, Harvard Medical SchoolEmail verificata su rics.bwh.harvard.edu
Atsuo T. SasakiUniversity of Cincinnati, College of MedicineEmail verificata su uc.edu
Evan C. LienAssistant Professor, Van Andel InstituteEmail verificata su vai.org
Elizabeth P HenskeProfessor of Medicine, Harvard Medical SchoolEmail verificata su bwh.harvard.edu
Mircea IvanIndiana UniversityEmail verificata su iu.edu
Mary Higby SchweitzerProfessor, Department of Biological Sciences, North Carolina State UniversityEmail verificata su ncsu.edu

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John Asara

Associate Professor Medicine, Harvard Medical School; Director, Beth Israel Deaconess Medical Center

Email verificata su bidmc.harvard.edu

Metabolomics Lipidomics Proteomics Mass Spectrometry Biochemistry


Titolo Ordina per citazioni Ordina per anno Ordina per titolo	Citata da Citata da	Anno
HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing M Ivan, K Kondo, H Yang, W Kim, J Valiando, M Ohh, A Salic, JM Asara, ... Science 292 (5516), 464-468, 2001	5947	2001
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy DF Egan, DB Shackelford, MM Mihaylova, S Gelino, RA Kohnz, W Mair, ... Science 331 (6016), 456-461, 2011	2774	2011
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ... Cell 149 (3), 656-670, 2012	2075	2012
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway J Son, CA Lyssiotis, H Ying, X Wang, S Hua, M Ligorio, RM Perera, ... Nature 496 (7443), 101-105, 2013	1997	2013
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis VS LeBleu, JT O’Connell, KN Gonzalez Herrera, H Wikman, K Pantel, ... Nature cell biology 16 (10), 992-1003, 2014	1401	2014
Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses D Anastasiou, G Poulogiannis, JM Asara, MB Boxer, J Jiang, M Shen, ... Science 334 (6060), 1278-1283, 2011	1259	2011
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation H Sano, S Kane, E Sano, CP Mı̂inea, JM Asara, WS Lane, CW Garner, ... Journal of Biological Chemistry 278 (17), 14599-14602, 2003	1255	2003
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function A Viale, P Pettazzoni, CA Lyssiotis, H Ying, N Sánchez, M Marchesini, ... Nature 514 (7524), 628-632, 2014	1242	2014
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ... Nature genetics 43 (9), 869-874, 2011	1207	2011
Pyruvate kinase M2 is a phosphotyrosine-binding protein HR Christofk, MG Vander Heiden, N Wu, JM Asara, LC Cantley Nature 452 (7184), 181-186, 2008	1188	2008
A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue M Yuan, SB Breitkopf, X Yang, JM Asara Nature protocols 7 (5), 872-881, 2012	1050	2012
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion CM Sousa, DE Biancur, X Wang, CJ Halbrook, MH Sherman, LI Zhang, ... Nature 536 (7617), 479-483, 2016	1043	2016
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ... Science 350 (6266), 1391-1396, 2015	937	2015
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1 I Ben-Sahra, JJ Howell, JM Asara, BD Manning Science 339 (6125), 1323-1328, 2013	828	2013
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012	809	2012
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning Science 351 (6274), 728-733, 2016	803	2016
An inhibitor of oxidative phosphorylation exploits cancer vulnerability JR Molina, Y Sun, M Protopopova, S Gera, M Bandi, C Bristow, T McAfoos, ... Nature medicine 24 (7), 1036-1046, 2018	788	2018
Evidence for an alternative glycolytic pathway in rapidly proliferating cells MG Vander Heiden, JW Locasale, KD Swanson, H Sharfi, GJ Heffron, ... Science 329 (5998), 1492-1499, 2010	746	2010
Small molecule inhibition of the autophagy kinase ULK1 and identification of ULK1 substrates DF Egan, MGH Chun, M Vamos, H Zou, J Rong, CJ Miller, HJ Lou, ... Molecular cell 59 (2), 285-297, 2015	711	2015
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1 N Wu, B Zheng, A Shaywitz, Y Dagon, C Tower, G Bellinger, CH Shen, ... Molecular cell 49 (6), 1167-1175, 2013	694	2013

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