Non‐viral CRISPR/Cas gene editing in vitro and in vivo enabled by synthetic nanoparticle co‐delivery of Cas9 mRNA and sgRNA JB Miller, S Zhang, P Kos, H Xiong, K Zhou, SS Perelman, H Zhu, ... Angewandte Chemie 129 (4), 1079-1083, 2017 | 588 | 2017 |
Arid1a has context-dependent oncogenic and tumor suppressor functions in liver cancer X Sun, SC Wang, Y Wei, X Luo, Y Jia, L Li, P Gopal, M Zhu, I Nassour, ... Cancer cell 32 (5), 574-589. e6, 2017 | 251 | 2017 |
Liver homeostasis is maintained by midlobular zone 2 hepatocytes Y Wei, YG Wang, Y Jia, L Li, J Yoon, S Zhang, Z Wang, Y Zhang, M Zhu, ... Science 371 (6532), eabb1625, 2021 | 196 | 2021 |
Dendrimer‐based lipid nanoparticles deliver therapeutic FAH mRNA to normalize liver function and extend survival in a mouse model of hepatorenal tyrosinemia type I Q Cheng, T Wei, Y Jia, L Farbiak, K Zhou, S Zhang, Y Wei, H Zhu, ... Advanced materials 30 (52), 1805308, 2018 | 195 | 2018 |
The Polyploid State Plays a Tumor-Suppressive Role in the Liver ZH Zhang S, Zhou K, Luo X, Li L, Tu HC, Sehgal A, Nguyen LH, Zhang Y, Gopal ... Developmental Cell 44 (4), 447-459, 2018 | 185 | 2018 |
Suppression of the SWI/SNF component Arid1a promotes mammalian regeneration X Sun, JC Chuang, M Kanchwala, L Wu, C Celen, L Li, H Liang, S Zhang, ... Cell stem cell 18 (4), 456-466, 2016 | 158 | 2016 |
Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division E Zatulovskiy, S Zhang, DF Berenson, BR Topacio, JM Skotheim Science 369 (6502), 466-471, 2020 | 133 | 2020 |
Increasing cell size remodels the proteome and promotes senescence MC Lanz, E Zatulovskiy, MP Swaffer, L Zhang, I Ilerten, S Zhang, DS You, ... Molecular cell 82 (17), 3255-3269. e8, 2022 | 124 | 2022 |
Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment C Celen, JC Chuang, X Luo, N Nijem, AK Walker, F Chen, S Zhang, ... elife 6, e25730, 2017 | 115 | 2017 |
Knockdown of anillin actin binding protein blocks cytokinesis in hepatocytes and reduces liver tumor development in mice without affecting regeneration S Zhang, LH Nguyen, K Zhou, HC Tu, A Sehgal, I Nassour, L Li, P Gopal, ... Gastroenterology 154 (5), 1421-1434, 2018 | 112 | 2018 |
SWI/SNF component ARID1A restrains pancreatic neoplasia formation SC Wang, I Nassour, S Xiao, S Zhang, X Luo, J Lee, L Li, X Sun, ... Gut 68 (7), 1259-1270, 2019 | 84 | 2019 |
Mice with increased numbers of polyploid hepatocytes maintain regenerative capacity but develop fewer hepatocellular carcinomas following chronic liver injury YH Lin, S Zhang, M Zhu, T Lu, K Chen, Z Wen, S Wang, G Xiao, D Luo, ... Gastroenterology 158 (6), 1698-1712. e14, 2020 | 73 | 2020 |
Precise let-7 expression levels balance organ regeneration against tumor suppression L Wu, LH Nguyen, K Zhou, TY de Soysa, L Li, JB Miller, J Tian, J Locker, ... Elife 4, e09431, 2015 | 70 | 2015 |
Aurora A orchestrates entosis by regulating a dynamic MCAK–TIP150 interaction P Xia, J Zhou, X Song, B Wu, X Liu, D Li, S Zhang, Z Wang, H Yu, T Ward, ... Journal of molecular cell biology 6 (3), 240-254, 2014 | 63 | 2014 |
Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking P Xia, X Liu, B Wu, S Zhang, X Song, PY Yao, J Lippincott-Schwartz, ... Molecular biology of the cell 25 (25), 4166-4173, 2014 | 57 | 2014 |
The origins and functions of hepatic polyploidy S Zhang, YH Lin, B Tarlow, H Zhu Cell cycle 18 (12), 1302-1315, 2019 | 46 | 2019 |
TALEN-mediated somatic mutagenesis in murine models of cancer S Zhang, L Li, SL Kendrick, RD Gerard, H Zhu Cancer research 74 (18), 5311-5321, 2014 | 42 | 2014 |
Delineation of proteome changes driven by cell size and growth rate E Zatulovskiy, MC Lanz, S Zhang, F McCarthy, JE Elias, JM Skotheim Frontiers in Cell and Developmental Biology 10, 980721, 2022 | 20 | 2022 |
The cell cycle inhibitor RB is diluted in G1 and contributes to controlling cell size in the mouse liver Shuyuan Zhang, Evgeny Zatulovskiy, Julia Arand, Julien Sage, Jan Skotheim Frontiers in cell and developmental biology 10 (doi: 10.3389/fcell.2022.965595.), 2022 | 8 | 2022 |
The G1-S transition is promoted by Rb degradation via the E3 ligase UBR5 S Zhang, LF Valenzuela, E Zatulovskiy, L Mangiante, C Curtis, ... Science Advances 10 (43), eadq6858, 2024 | 6 | 2024 |