A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP. 664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies RW Sanders, R Derking, A Cupo, JP Julien, A Yasmeen, N de Val, HJ Kim, ... PLoS pathogens 9 (9), e1003618, 2013 | 1020 | 2013 |
Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface J Huang, BH Kang, M Pancera, JH Lee, T Tong, Y Feng, H Imamichi, ... Nature 515 (7525), 138-142, 2014 | 519 | 2014 |
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers C Blattner, JH Lee, K Sliepen, R Derking, E Falkowska, AT de la Peña, ... Immunity 40 (5), 669-680, 2014 | 403 | 2014 |
Immunogenicity of stabilized HIV-1 envelope trimers with reduced exposure of non-neutralizing epitopes SW De Taeye, G Ozorowski, AT de la Peña, M Guttman, JP Julien, ... Cell 163 (7), 1702-1715, 2015 | 356 | 2015 |
Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches M Pauthner, C Havenar-Daughton, D Sok, JP Nkolola, R Bastidas, ... Immunity 46 (6), 1073-1088. e6, 2017 | 314 | 2017 |
Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans F Garces, JH Lee, N de Val, AT de la Pena, L Kong, C Puchades, Y Hua, ... Immunity 43 (6), 1053-1063, 2015 | 225 | 2015 |
Cytokine-independent detection of antigen-specific germinal center T follicular helper cells in immunized nonhuman primates using a live cell activation-induced marker technique C Havenar-Daughton, SM Reiss, DG Carnathan, JE Wu, K Kendric, ... The Journal of Immunology 197 (3), 994-1002, 2016 | 210 | 2016 |
Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer C Havenar-Daughton, DG Carnathan, AT de la Peña, M Pauthner, ... Cell reports 17 (9), 2195-2209, 2016 | 171 | 2016 |
Improving the immunogenicity of native-like HIV-1 envelope trimers by hyperstabilization AT de la Pena, JP Julien, SW de Taeye, F Garces, M Guttman, ... Cell reports 20 (8), 1805-1817, 2017 | 158 | 2017 |
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence K Sliepen, BW Han, I Bontjer, P Mooij, F Garces, AJ Behrens, ... Nature communications 10 (1), 2355, 2019 | 138 | 2019 |
Design and structure of two HIV-1 clade C SOSIP. 664 trimers that increase the arsenal of native-like Env immunogens JP Julien, JH Lee, G Ozorowski, Y Hua, A Torrents de la Peña, ... Proceedings of the National Academy of Sciences 112 (38), 11947-11952, 2015 | 127 | 2015 |
Three mutations switch H7N9 influenza to human-type receptor specificity RP De Vries, W Peng, OC Grant, AJ Thompson, X Zhu, KM Bouwman, ... PLoS pathogens 13 (6), e1006390, 2017 | 108 | 2017 |
Broadly neutralizing antibodies target a haemagglutinin anchor epitope JJ Guthmiller, J Han, HA Utset, L Li, LYL Lan, C Henry, CT Stamper, ... Nature 602 (7896), 314-320, 2022 | 101 | 2022 |
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike JH Lee, DP Leaman, AS Kim, A Torrents de La Peña, K Sliepen, ... Nature communications 6 (1), 8167, 2015 | 99 | 2015 |
Immunogenicity in rabbits of HIV-1 SOSIP trimers from clades A, B, and C, given individually, sequentially, or in combination A Torrents de la Peña, SW de Taeye, K Sliepen, CC LaBranche, ... Journal of virology 92 (8), 10.1128/jvi. 01957-17, 2018 | 82 | 2018 |
Nocturnal plasma melatonin in humans: episodic pattern and influence of light GM Vaughan, R Bell, A De La Pena Neuroscience Letters 14 (1), 81-84, 1979 | 79 | 1979 |
Complete epitopes for vaccine design derived from a crystal structure of the broadly neutralizing antibodies PGT128 and 8ANC195 in complex with an HIV-1 Env trimer L Kong, A Torrents de la Peña, MC Deller, F Garces, K Sliepen, Y Hua, ... Acta Crystallographica Section D: Biological Crystallography 71 (10), 2099-2108, 2015 | 70 | 2015 |
Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics A Torrents de la Peña, K Rantalainen, CA Cottrell, JD Allen, MJ van Gils, ... PLoS pathogens 15 (7), e1007920, 2019 | 66 | 2019 |
A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human‐type receptors RP de Vries, N Tzarum, W Peng, AJ Thompson, ... EMBO molecular medicine 9 (9), 1314-1325, 2017 | 53 | 2017 |
Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens T Schiffner, N de Val, RA Russell, SW de Taeye, AT de la Peña, ... Journal of virology 90 (2), 813-828, 2016 | 48 | 2016 |