The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells LP Vu, BF Pickering, Y Cheng, S Zaccara, D Nguyen, G Minuesa, T Chou, ... Nature medicine 23 (11), 1369-1376, 2017 | 1101 | 2017 |
The Lin28/let-7 axis regulates glucose metabolism H Zhu, N Shyh-Chang, AV Segrè, G Shinoda, SP Shah, WS Einhorn, ... Cell 147 (1), 81-94, 2011 | 1010 | 2011 |
Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera G Wernig, MG Kharas, R Okabe, SA Moore, DS Leeman, DE Cullen, ... Cancer cell 13 (4), 311-320, 2008 | 464 | 2008 |
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia MG Kharas, CJ Lengner, F Al-Shahrour, L Bullinger, B Ball, S Zaidi, ... Nature medicine 16 (8), 903-908, 2010 | 431 | 2010 |
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells A Mullally, SW Lane, B Ball, C Megerdichian, R Okabe, F Al-Shahrour, ... Cancer cell 17 (6), 584-596, 2010 | 423 | 2010 |
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer A Bosch, Z Li, A Bergamaschi, H Ellis, E Toska, A Prat, JJ Tao, DE Spratt, ... Science translational medicine 7 (283), 283ra51-283ra51, 2015 | 361 | 2015 |
Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice MG Kharas, R Okabe, JJ Ganis, M Gozo, T Khandan, M Paktinat, ... Blood, The Journal of the American Society of Hematology 115 (7), 1406-1415, 2010 | 343 | 2010 |
ABL Oncogenes and Phosphoinositide 3-Kinase: Mechanism of Activation and Downstream Effectors MG Kharas, DA Fruman Cancer research 65 (6), 2047-2053, 2005 | 218 | 2005 |
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis I Hofmann, EH Stover, DE Cullen, J Mao, KJ Morgan, BH Lee, MG Kharas, ... Cell stem cell 4 (6), 559-567, 2009 | 215 | 2009 |
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells MG Kharas, MR Janes, VM Scarfone, MB Lilly, ZA Knight, KM Shokat, ... The Journal of clinical investigation 118 (9), 3038-3050, 2008 | 189 | 2008 |
In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling PG Miller, F Al-Shahrour, KA Hartwell, LP Chu, M Järås, RV Puram, ... Cancer cell 24 (1), 45-58, 2013 | 181 | 2013 |
Optimal B-cell proliferation requires phosphoinositide 3-kinase–dependent inactivation of FOXO transcription factors I Yusuf, X Zhu, MG Kharas, J Chen, DA Fruman Blood 104 (3), 784-787, 2004 | 173 | 2004 |
Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs SM Park, RP Deering, Y Lu, P Tivnan, S Lianoglou, F Al-Shahrour, ... Journal of Experimental Medicine 211 (1), 71-87, 2014 | 172 | 2014 |
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation Y Cheng, W Xie, BF Pickering, KL Chu, AM Savino, X Yang, H Luo, ... Cancer cell 39 (7), 958-972. e8, 2021 | 163 | 2021 |
Stage-specific human induced pluripotent stem cells map the progression of myeloid transformation to transplantable leukemia AG Kotini, CJ Chang, A Chow, H Yuan, TC Ho, T Wang, S Vora, ... Cell stem cell 20 (3), 315-328. e7, 2017 | 152 | 2017 |
m6A RNA methylation maintains hematopoietic stem cell identity and symmetric commitment Y Cheng, H Luo, F Izzo, BF Pickering, D Nguyen, R Myers, A Schurer, ... Cell reports 28 (7), 1703-1716. e6, 2019 | 151 | 2019 |
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells Y Wang, FS Yen, XG Zhu, RC Timson, R Weber, C Xing, Y Liu, B Allwein, ... Nature 599 (7883), 136-140, 2021 | 149 | 2021 |
The Biology of m6A RNA Methylation in Normal and Malignant Hematopoiesis LP Vu, Y Cheng, MG Kharas Cancer discovery 9 (1), 25-33, 2019 | 145 | 2019 |
Transformation of the intestinal epithelium by the MSI2 RNA-binding protein S Wang, N Li, M Yousefi, A Nakauka-Ddamba, F Li, K Parada, S Rao, ... Nature communications 6 (1), 6517, 2015 | 139 | 2015 |
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia G Minuesa, SK Albanese, W Xie, Y Kazansky, D Worroll, A Chow, ... Nature communications 10 (1), 2691, 2019 | 128 | 2019 |