| Aptamers as therapeutics AD Keefe, S Pai, A Ellington Nature reviews Drug discovery 9 (7), 537-550, 2010 | 2545 | 2010 |
| Functional proteins from a random-sequence library AD Keefe, JW Szostak Nature 410 (6829), 715-718, 2001 | 821 | 2001 |
| The use of mRNA display to select high-affinity protein-binding peptides DS Wilson, AD Keefe, JW Szostak Proceedings of the National Academy of Sciences 98 (7), 3750-3755, 2001 | 643 | 2001 |
| DNA-encoded chemistry: enabling the deeper sampling of chemical space RA Goodnow Jr, CE Dumelin, AD Keefe Nature Reviews Drug Discovery 16 (2), 131-147, 2017 | 554 | 2017 |
| Direct in vitro selection of a 2′-O-methyl aptamer to VEGF PE Burmeister, SD Lewis, RF Silva, JR Preiss, LR Horwitz, ... Chemistry & Biology 12 (1), 25-33, 2005 | 446 | 2005 |
| SELEX with modified nucleotides AD Keefe, ST Cload Current opinion in chemical biology 12 (4), 448-456, 2008 | 392 | 2008 |
| One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag AD Keefe, DS Wilson, B Seelig, JW Szostak Protein expression and purification 23 (3), 440-446, 2001 | 319 | 2001 |
| Building oligonucleotide therapeutics using non-natural chemistries C Wilson, AD Keefe Current opinion in chemical biology 10 (6), 607-614, 2006 | 253 | 2006 |
| Random mutagenesis by PCR DS Wilson, AD Keefe Current protocols in molecular biology. John Wiley & Sons, Inc …, 2000 | 187 | 2000 |
| Are polyphosphates or phosphate esters prebiotic reagents? AD Keefe, SL Miller Journal of molecular evolution 41, 693-702, 1995 | 185 | 1995 |
| Constructing high complexity synthetic libraries of long ORFs using In vitro selection G Cho, AD Keefe, R Liu, DS Wilson, JW Szostak Journal of molecular biology 297 (2), 309-319, 2000 | 161 | 2000 |
| Machine learning on DNA-encoded libraries: a new paradigm for hit finding K McCloskey, EA Sigel, S Kearnes, L Xue, X Tian, D Moccia, D Gikunju, ... Journal of Medicinal Chemistry 63 (16), 8857-8866, 2020 | 142 | 2020 |
| Nucleic acid sensor molecules and methods of using same M Stanton, D Epstein, N Hamaguchi, M Kurz, AD Keefe, C Wilson, D Grate, ... US Patent 7,125,660, 2006 | 134 | 2006 |
| Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library CMA Litovchick A, Dumelin CE, Habeshian S, Gikunju D, Guié MA, Centrella P ... Sci Rep. 5, 10916, 2015 | 109 | 2015 |
| Materials and methods for the generation of fully 2′-modified nucleic acid transcripts JL Diener, AD Keefe, K Thompson, C Wang, S Zhu US Patent 8,105,813, 2012 | 108 | 2012 |
| Aptamers as candidate therapeutics for cardiovascular indications AD Keefe, RG Schaub Current opinion in pharmacology 8 (2), 147-152, 2008 | 107 | 2008 |
| A possible prebiotic synthesis of pantetheine, a precursor to coenzyme A AD Keefe, GL Newton, SL Miller Nature 373 (6516), 683-685, 1995 | 96 | 1995 |
| Aptamer-mediated intracellular delivery of therapeutic oligonucleotides D Epstein, S Pendergrast, AD Keefe, A Corporation EP Patent 1,737,879, 2007 | 95* | 2007 |
| Novel autotaxin inhibitor for the treatment of idiopathic pulmonary fibrosis: a clinical candidate discovered using DNA-encoded chemistry JW Cuozzo, MA Clark, AD Keefe, A Kohlmann, M Mulvihill, H Ni, ... Journal of Medicinal Chemistry 63 (14), 7840-7856, 2020 | 87 | 2020 |
| 2'-Deoxy purine, 2'-O-methyl pyrimidine (dRmY) aptamers as candidate therapeutics PE Burmeister, C Wang, JR Killough, SD Lewis, LR Horwitz, A Ferguson, ... Oligonucleotides 16 (4), 337-351, 2006 | 87 | 2006 |