| Trifluoroethanol-induced stabilization of the α-helical structure of β-lactoglobulin: implication for non-hierarchical protein folding K Shiraki, K Nishikawa, Y Goto Journal of molecular biology 245 (2), 180-194, 1995 | 561 | 1995 |
| Biophysical effect of amino acids on the prevention of protein aggregation K Shiraki, M Kudou, S Fujiwara, T Imanaka, M Takagi The Journal of Biochemistry 132 (4), 591-595, 2002 | 318 | 2002 |
| Effect of additives on protein aggregation H Hamada, T Arakawa, K Shiraki Current pharmaceutical biotechnology 10 (4), 400-407, 2009 | 316 | 2009 |
| Chemical modification of amino acids by atmospheric-pressure cold plasma in aqueous solution E Takai, T Kitamura, J Kuwabara, S Ikawa, S Yoshizawa, K Shiraki, ... Journal of Physics D: Applied Physics 47 (28), 285403, 2014 | 303 | 2014 |
| Protein inactivation by low‐temperature atmospheric pressure plasma in aqueous solution E Takai, K Kitano, J Kuwabara, K Shiraki Plasma Processes and Polymers 9 (1), 77-82, 2012 | 204 | 2012 |
| Prevention of thermal inactivation and aggregation of lysozyme by polyamines M Kudou, K Shiraki, S Fujiwara, T Imanaka, M Takagi European Journal of Biochemistry 270 (22), 4547-4554, 2003 | 168 | 2003 |
| Mechanistic insights into protein precipitation by alcohol H Yoshikawa, A Hirano, T Arakawa, K Shiraki International journal of biological macromolecules 50 (3), 865-871, 2012 | 128 | 2012 |
| Specific decrease in solution viscosity of antibodies by arginine for therapeutic formulations N Inoue, E Takai, T Arakawa, K Shiraki Molecular pharmaceutics 11 (6), 1889-1896, 2014 | 127 | 2014 |
| Viscosity control of protein solution by small solutes: a review T Hong, K Iwashita, K Shiraki Current Protein and Peptide Science 19 (8), 746-758, 2018 | 116 | 2018 |
| Synergistic solubilization of porcine myosin in physiological salt solution by arginine E Takai, S Yoshizawa, D Ejima, T Arakawa, K Shiraki International journal of biological macromolecules 62, 647-651, 2013 | 109 | 2013 |
| Arginine-assisted solubilization system for drug substances: solubility experiment and simulation A Hirano, T Kameda, T Arakawa, K Shiraki The Journal of Physical Chemistry B 114 (42), 13455-13462, 2010 | 104 | 2010 |
| Discovery of posttranslational maturation by self-subunit swapping Z Zhou, Y Hashimoto, K Shiraki, M Kobayashi Proceedings of the National Academy of Sciences 105 (39), 14849-14854, 2008 | 101 | 2008 |
| A new class of glutathione S-transferase from the hepatopancreas of the red sea bream Pagrus major T Konishi, K Kato, T Araki, K Shiraki, M Takagi, Y Tamaru Biochemical Journal 388 (1), 299-307, 2005 | 101 | 2005 |
| Arginine ethylester prevents thermal inactivation and aggregation of lysozyme K Shiraki, M Kudou, S Nishikori, H Kitagawa, T Imanaka, M Takagi European journal of biochemistry 271 (15), 3242-3247, 2004 | 98 | 2004 |
| Characterization of phytochelatin synthase-like protein encoded by alr0975 from a prokaryote, Nostoc sp. PCC 7120 N Tsuji, S Nishikori, O Iwabe, K Shiraki, H Miyasaka, M Takagi, K Hirata, ... Biochemical and Biophysical Research Communications 315 (3), 751-755, 2004 | 91 | 2004 |
| Arginine increases the solubility of coumarin: comparison with salting-in and salting-out additives A Hirano, T Arakawa, K Shiraki Journal of biochemistry 144 (3), 363-369, 2008 | 89 | 2008 |
| Effects of alcohol on the solubility and structure of native and disulfide-modified bovine serum albumin H Yoshikawa, A Hirano, T Arakawa, K Shiraki International journal of biological macromolecules 50 (5), 1286-1291, 2012 | 87 | 2012 |
| High-resolution X-ray analysis reveals binding of arginine to aromatic residues of lysozyme surface: implication of suppression of protein aggregation by arginine L Ito, K Shiraki, T Matsuura, M Okumura, K Hasegawa, S Baba, ... Protein Engineering, Design & Selection 24 (3), 269-274, 2011 | 84 | 2011 |
| 1, 6-hexanediol rapidly immobilizes and condenses chromatin in living human cells Y Itoh, S Iida, S Tamura, R Nagashima, K Shiraki, T Goto, K Hibino, S Ide, ... Life science alliance 4 (4), 2021 | 81 | 2021 |
| Arginine and lysine reduce the high viscosity of serum albumin solutions for pharmaceutical injection N Inoue, E Takai, T Arakawa, K Shiraki Journal of bioscience and bioengineering 117 (5), 539-543, 2014 | 81 | 2014 |