Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 … XL Du, D Edelstein, L Rossetti, IG Fantus, H Goldberg, F Ziyadeh, J Wu, ... Proceedings of the National Academy of Sciences 97 (22), 12222-12226, 2000 | 1546 | 2000 |
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth … FN Ziyadeh, BB Hoffman, DC Han, MC Iglesias-De la Cruz, SW Hong, ... Proceedings of the National Academy of Sciences 97 (14), 8015-8020, 2000 | 1179 | 2000 |
Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice K Sharma, Y Jin, J Guo, FN Ziyadeh Diabetes 45 (4), 522-530, 1996 | 909 | 1996 |
From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy G Wolf, S Chen, FN Ziyadeh Diabetes 54 (6), 1626-1634, 2005 | 866 | 2005 |
Hyperglycemia and diabetic kidney disease: The case for transforming growth factor–β as a key mediator K Sharma, FN Ziyadeh Diabetes 44 (10), 1139-1146, 1995 | 812 | 1995 |
Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-beta. FN Ziyadeh, K Sharma, M Ericksen, G Wolf The Journal of clinical investigation 93 (2), 536-542, 1994 | 776 | 1994 |
Molecular mechanisms of diabetic renal hypertrophy G Wolf, FN Ziyadeh Kidney international 56 (2), 393-405, 1999 | 732 | 1999 |
Mediators of diabetic renal disease: the case for TGF-β as the major mediator FN Ziyadeh Journal of the American Society of Nephrology 15 (1_suppl), S55-S57, 2004 | 715 | 2004 |
Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation F Strutz, M Zeisberg, FN Ziyadeh, CQ Yang, R Kalluri, GA Müller, ... Kidney international 61 (5), 1714-1728, 2002 | 664 | 2002 |
Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells: potential role in glomerulosclerosis G Wolf, A Hamann, DC Han, U Helmchen, F Thaiss, FN Ziyadeh, ... Kidney international 56 (3), 860-872, 1999 | 605 | 1999 |
Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy FN Ziyadeh, G Wolf Current diabetes reviews 4 (1), 39-45, 2008 | 595 | 2008 |
Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta. G Wolf, E Mueller, RA Stahl, FN Ziyadeh The Journal of clinical investigation 92 (3), 1366-1372, 1993 | 467 | 1993 |
High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β G Wolf, K Sharma, Y Chen, M Ericksen, FN Ziyadeh Kidney international 42 (3), 647-656, 1992 | 442 | 1992 |
Leptin and renal disease G Wolf, S Chen, DC Han, FN Ziyadeh American Journal of Kidney Diseases 39 (1), 1-11, 2002 | 439 | 2002 |
Diabetic nephropathy and transforming growth factor-β: transforming our view of glomerulosclerosis and fibrosis build-up S Chen, B Jim, FN Ziyadeh Seminars in nephrology 23 (6), 532-543, 2003 | 437 | 2003 |
Cellular and molecular mechanisms of proteinuria in diabetic nephropathy G Wolf, FN Ziyadeh Nephron Physiology 106 (2), p26-p31, 2007 | 395 | 2007 |
Increased renal production of transforming growth factor-β1 in patients with type II diabetes K Sharma, FN Ziyadeh, B Alzahabi, TA McGowan, S Kapoor, BRC Kurnik, ... Diabetes 46 (5), 854-859, 1997 | 394 | 1997 |
The emerging role of transforming growth factor-beta in kidney diseases K Sharma, FN Ziyadeh American Journal of Physiology-Renal Physiology 266 (6), F829-F842, 1994 | 380 | 1994 |
Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule MV Rocco, Y Chen, S Goldfarb, FN Ziyadeh Kidney international 41 (1), 107-114, 1992 | 364 | 1992 |
The role of angiotensin II in diabetic nephropathy: emphasis on nonhemodynamic mechanisms G Wolf, FN Ziyadeh American journal of kidney diseases 29 (1), 153-163, 1997 | 354 | 1997 |