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Stephanie Grabow
Stephanie Grabow
Merrimack Pharmaceuticals
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Citata da
Citata da
Anno
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
ARD Delbridge, S Grabow, A Strasser, DL Vaux
Nature Reviews Cancer 16 (2), 99-109, 2016
8492016
XIAP discriminates between type I and type II FAS-induced apoptosis
PJ Jost, S Grabow, D Gray, MD McKenzie, U Nachbur, DCS Huang, ...
Nature 460 (7258), 1035-1039, 2009
5982009
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis
LA O’Reilly, L Tai, L Lee, EA Kruse, S Grabow, WD Fairlie, NM Haynes, ...
Nature 461 (7264), 659-663, 2009
4602009
Embryogenesis and adult life in the absence of intrinsic apoptosis effectors BAX, BAK, and BOK
FFS Ke, HK Vanyai, AD Cowan, ARD Delbridge, L Whitehead, S Grabow, ...
Cell 173 (5), 1217-1230. e17, 2018
2022018
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53
GL Kelly, S Grabow, SP Glaser, L Fitzsimmons, BJ Aubrey, T Okamoto, ...
Genes & development 28 (1), 58-70, 2014
1872014
The rise of apoptosis: targeting apoptosis in hematologic malignancies
R Valentin, S Grabow, MS Davids
Blood, The Journal of the American Society of Hematology 132 (12), 1248-1264, 2018
1562018
Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer
S Yasmin-Karim, PT Bruck, M Moreau, S Kunjachan, GZ Chen, R Kumar, ...
Frontiers in immunology 9, 2030, 2018
852018
Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival
C Viant, S Guia, RJ Hennessy, J Rautela, K Pham, C Bernat, W Goh, ...
Journal of Experimental Medicine 214 (2), 491-510, 2017
712017
MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development
BN Sheikh, SCW Lee, F El-Saafin, HK Vanyai, Y Hu, SHM Pang, ...
Blood, The Journal of the American Society of Hematology 125 (12), 1910-1921, 2015
632015
Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells
EM Carrington, JG Zhang, RM Sutherland, IB Vikstrom, JL Brady, P Soo, ...
Proceedings of the National Academy of Sciences 112 (13), 4044-4049, 2015
602015
Physiological restraint of Bak by Bcl-xL is essential for cell survival
EF Lee, S Grabow, S Chappaz, G Dewson, C Hockings, RM Kluck, ...
Genes & development 30 (10), 1240-1250, 2016
572016
Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice
PN Kelly, S Grabow, ARD Delbridge, A Strasser, JM Adams
Blood, The Journal of the American Society of Hematology 118 (24), 6380-6386, 2011
562011
Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity
EM Tam, RB Fulton, JF Sampson, M Muda, A Camblin, J Richards, ...
Science translational medicine 11 (512), eaax0720, 2019
492019
Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models
WS Kamoun, DB Kirpotin, ZR Huang, SK Tipparaju, CO Noble, ME Hayes, ...
Nature Biomedical Engineering 3 (4), 264-280, 2019
492019
Loss of a single Mcl-1 allele inhibits MYC-driven lymphomagenesis by sensitizing pro-B cells to apoptosis
S Grabow, ARD Delbridge, BJ Aubrey, CJ Vandenberg, A Strasser
Cell reports 14 (10), 2337-2347, 2016
482016
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice
S Grabow, ARD Delbridge, LJ Valente, A Strasser
Blood, The Journal of the American Society of Hematology 124 (26), 3939-3946, 2014
482014
Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress
ARD Delbridge, JT Opferman, S Grabow, A Strasser
Blood, The Journal of the American Society of Hematology 125 (21), 3273-3280, 2015
432015
Subtle changes in the levels of BCL-2 proteins cause severe craniofacial abnormalities
S Grabow, AJ Kueh, F Ke, HK Vanyai, BN Sheikh, MA Dengler, W Chiang, ...
Cell Reports 24 (12), 3285-3295. e4, 2018
412018
Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53
LJ Valente, S Grabow, CJ Vandenberg, A Strasser, A Janic
Oncogene 35 (29), 3866-3871, 2016
372016
Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK
F Ke, S Grabow, GL Kelly, A Lin, LA O’reilly, A Strasser
Cell death & disease 6 (10), e1938-e1938, 2015
362015
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