Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies ARD Delbridge, S Grabow, A Strasser, DL Vaux Nature Reviews Cancer 16 (2), 99-109, 2016 | 849 | 2016 |
XIAP discriminates between type I and type II FAS-induced apoptosis PJ Jost, S Grabow, D Gray, MD McKenzie, U Nachbur, DCS Huang, ... Nature 460 (7258), 1035-1039, 2009 | 598 | 2009 |
Membrane-bound Fas ligand only is essential for Fas-induced apoptosis LA O’Reilly, L Tai, L Lee, EA Kruse, S Grabow, WD Fairlie, NM Haynes, ... Nature 461 (7264), 659-663, 2009 | 460 | 2009 |
Embryogenesis and adult life in the absence of intrinsic apoptosis effectors BAX, BAK, and BOK FFS Ke, HK Vanyai, AD Cowan, ARD Delbridge, L Whitehead, S Grabow, ... Cell 173 (5), 1217-1230. e17, 2018 | 202 | 2018 |
Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53 GL Kelly, S Grabow, SP Glaser, L Fitzsimmons, BJ Aubrey, T Okamoto, ... Genes & development 28 (1), 58-70, 2014 | 187 | 2014 |
The rise of apoptosis: targeting apoptosis in hematologic malignancies R Valentin, S Grabow, MS Davids Blood, The Journal of the American Society of Hematology 132 (12), 1248-1264, 2018 | 156 | 2018 |
Radiation and Local Anti-CD40 Generate an Effective in situ Vaccine in Preclinical Models of Pancreatic Cancer S Yasmin-Karim, PT Bruck, M Moreau, S Kunjachan, GZ Chen, R Kumar, ... Frontiers in immunology 9, 2030, 2018 | 85 | 2018 |
Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival C Viant, S Guia, RJ Hennessy, J Rautela, K Pham, C Bernat, W Goh, ... Journal of Experimental Medicine 214 (2), 491-510, 2017 | 71 | 2017 |
MOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development BN Sheikh, SCW Lee, F El-Saafin, HK Vanyai, Y Hu, SHM Pang, ... Blood, The Journal of the American Society of Hematology 125 (12), 1910-1921, 2015 | 63 | 2015 |
Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells EM Carrington, JG Zhang, RM Sutherland, IB Vikstrom, JL Brady, P Soo, ... Proceedings of the National Academy of Sciences 112 (13), 4044-4049, 2015 | 60 | 2015 |
Physiological restraint of Bak by Bcl-xL is essential for cell survival EF Lee, S Grabow, S Chappaz, G Dewson, C Hockings, RM Kluck, ... Genes & development 30 (10), 1240-1250, 2016 | 57 | 2016 |
Endogenous Bcl-xL is essential for Myc-driven lymphomagenesis in mice PN Kelly, S Grabow, ARD Delbridge, A Strasser, JM Adams Blood, The Journal of the American Society of Hematology 118 (24), 6380-6386, 2011 | 56 | 2011 |
Antibody-mediated targeting of TNFR2 activates CD8+ T cells in mice and promotes antitumor immunity EM Tam, RB Fulton, JF Sampson, M Muda, A Camblin, J Richards, ... Science translational medicine 11 (512), eaax0720, 2019 | 49 | 2019 |
Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models WS Kamoun, DB Kirpotin, ZR Huang, SK Tipparaju, CO Noble, ME Hayes, ... Nature Biomedical Engineering 3 (4), 264-280, 2019 | 49 | 2019 |
Loss of a single Mcl-1 allele inhibits MYC-driven lymphomagenesis by sensitizing pro-B cells to apoptosis S Grabow, ARD Delbridge, BJ Aubrey, CJ Vandenberg, A Strasser Cell reports 14 (10), 2337-2347, 2016 | 48 | 2016 |
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice S Grabow, ARD Delbridge, LJ Valente, A Strasser Blood, The Journal of the American Society of Hematology 124 (26), 3939-3946, 2014 | 48 | 2014 |
Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stress ARD Delbridge, JT Opferman, S Grabow, A Strasser Blood, The Journal of the American Society of Hematology 125 (21), 3273-3280, 2015 | 43 | 2015 |
Subtle changes in the levels of BCL-2 proteins cause severe craniofacial abnormalities S Grabow, AJ Kueh, F Ke, HK Vanyai, BN Sheikh, MA Dengler, W Chiang, ... Cell Reports 24 (12), 3285-3295. e4, 2018 | 41 | 2018 |
Combined loss of PUMA and p21 accelerates c-MYC-driven lymphoma development considerably less than loss of one allele of p53 LJ Valente, S Grabow, CJ Vandenberg, A Strasser, A Janic Oncogene 35 (29), 3866-3871, 2016 | 37 | 2016 |
Impact of the combined loss of BOK, BAX and BAK on the hematopoietic system is slightly more severe than compound loss of BAX and BAK F Ke, S Grabow, GL Kelly, A Lin, LA O’reilly, A Strasser Cell death & disease 6 (10), e1938-e1938, 2015 | 36 | 2015 |