Chemical transformation of xenobiotics by the human gut microbiota N Koppel, V Maini Rekdal, EP Balskus Science 356 (6344), eaag2770, 2017 | 931 | 2017 |
Minimum information about a biosynthetic gene cluster MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ... Nature chemical biology 11 (9), 625-631, 2015 | 913 | 2015 |
Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta HJ Haiser, DB Gootenberg, K Chatman, G Sirasani, EP Balskus, ... Science 341 (6143), 295-298, 2013 | 725 | 2013 |
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme S Craciun, EP Balskus Proceedings of the National Academy of Sciences 109 (52), 21307-21312, 2012 | 723 | 2012 |
Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism V Maini Rekdal, EN Bess, JE Bisanz, PJ Turnbaugh, EP Balskus Science 364 (6445), eaau6323, 2019 | 653 | 2019 |
The human gut bacterial genotoxin colibactin alkylates DNA MR Wilson, Y Jiang, PW Villalta, A Stornetta, PD Boudreau, A Carrá, ... Science 363 (6428), eaar7785, 2019 | 508 | 2019 |
The genetic and molecular basis for sunscreen biosynthesis in cyanobacteria EP Balskus, CT Walsh Science 329 (5999), 1653-1656, 2010 | 409 | 2010 |
Trimethylamine N-oxide binds and activates PERK to promote metabolic dysfunction S Chen, A Henderson, MC Petriello, KA Romano, M Gearing, J Miao, ... Cell metabolism 30 (6), 1141-1151. e5, 2019 | 296 | 2019 |
Cholesterol metabolism by uncultured human gut bacteria influences host cholesterol level DJ Kenny, DR Plichta, D Shungin, N Koppel, AB Hall, B Fu, RS Vasan, ... Cell host & microbe 28 (2), 245-257. e6, 2020 | 222 | 2020 |
Characterization and detection of a widely distributed gene cluster that predicts anaerobic choline utilization by human gut bacteria A Martínez-del Campo, S Bodea, HA Hamer, JA Marks, HJ Haiser, ... MBio 6 (2), 10.1128/mbio. 00042-15, 2015 | 196 | 2015 |
Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics HJ Haiser, KL Seim, EP Balskus, PJ Turnbaugh Gut microbes 5 (2), 233-238, 2014 | 195 | 2014 |
A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity CA Brotherton, EP Balskus Journal of the American Chemical Society 135 (9), 3359-3362, 2013 | 189 | 2013 |
Metabolic, epigenetic, and transgenerational effects of gut bacterial choline consumption KA Romano, A Martinez-del Campo, K Kasahara, CL Chittim, EI Vivas, ... Cell host & microbe 22 (3), 279-290. e7, 2017 | 186 | 2017 |
α, β-Unsaturated β-Silyl Imide Substrates for Catalytic, Enantioselective Conjugate Additions: A Total Synthesis of (+)-Lactacystin and the Discovery of a New Proteasome Inhibitor EP Balskus, EN Jacobsen Journal of the American Chemical Society 128 (21), 6810-6812, 2006 | 168 | 2006 |
Heteroatom–heteroatom bond formation in natural product biosynthesis AJ Waldman, TL Ng, P Wang, EP Balskus Chemical reviews 117 (8), 5784-5863, 2017 | 164 | 2017 |
Investigating the initial steps in the biosynthesis of cyanobacterial sunscreen scytonemin EP Balskus, CT Walsh Journal of the American Chemical Society 130 (46), 15260-15261, 2008 | 160 | 2008 |
A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-l-proline BJ Levin, YY Huang, SC Peck, Y Wei, A Martinez-Del Campo, JA Marks, ... Science 355 (6325), eaai8386, 2017 | 159 | 2017 |
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia SC Peck, K Denger, A Burrichter, SM Irwin, EP Balskus, D Schleheck Proceedings of the National Academy of Sciences 116 (8), 3171-3176, 2019 | 158 | 2019 |
Exploring and understanding the biochemical diversity of the human microbiota N Koppel, EP Balskus Cell chemical biology 23 (1), 18-30, 2016 | 157 | 2016 |
Characterization of choline trimethylamine-lyase expands the chemistry of glycyl radical enzymes S Craciun, JA Marks, EP Balskus ACS chemical biology 9 (7), 1408-1413, 2014 | 143 | 2014 |