A SARS-CoV-2 protein interaction map reveals targets for drug repurposing DE Gordon, GM Jang, M Bouhaddou, J Xu, K Obernier, KM White, ... Nature 583 (7816), 459-468, 2020 | 4671 | 2020 |
The global phosphorylation landscape of SARS-CoV-2 infection M Bouhaddou, D Memon, B Meyer, KM White, VV Rezelj, MC Marrero, ... Cell 182 (3), 685-712. e19, 2020 | 941 | 2020 |
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing L Riva, S Yuan, X Yin, L Martin-Sancho, N Matsunaga, L Pache, ... Nature 586 (7827), 113-119, 2020 | 772 | 2020 |
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 669 | 2020 |
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling L Miorin, T Kehrer, MT Sanchez-Aparicio, K Zhang, P Cohen, RS Patel, ... Proceedings of the National Academy of Sciences 117 (45), 28344-28354, 2020 | 511 | 2020 |
Transcription elongation can affect genome 3D structure S Heinz, L Texari, MGB Hayes, M Urbanowski, MW Chang, N Givarkes, ... Cell 174 (6), 1522-1536. e22, 2018 | 417 | 2018 |
Evolution of enhanced innate immune evasion by SARS-CoV-2 LG Thorne, M Bouhaddou, AK Reuschl, L Zuliani-Alvarez, B Polacco, ... Nature 602 (7897), 487-495, 2022 | 410 | 2022 |
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 402 | 2020 |
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A KM White, R Rosales, S Yildiz, T Kehrer, L Miorin, E Moreno, S Jangra, ... Science 371 (6532), 926-931, 2021 | 315 | 2021 |
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19 B Boras, RM Jones, BJ Anson, D Arenson, L Aschenbrenner, ... Nature communications 12 (1), 6055, 2021 | 235 | 2021 |
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ... Cell stem cell 29 (2), 217-231. e8, 2022 | 199 | 2022 |
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 TA Tummino, VV Rezelj, B Fischer, A Fischer, MJ O’meara, B Monel, ... Science 373 (6554), 541-547, 2021 | 185 | 2021 |
An in vitro microneutralization assay for SARS‐CoV‐2 serology and drug screening F Amanat, KM White, L Miorin, S Strohmeier, M McMahon, P Meade, ... Current protocols in microbiology 58 (1), e108, 2020 | 184 | 2020 |
COVID-19: famotidine, histamine, mast cells, and mechanisms RW Malone, P Tisdall, P Fremont-Smith, Y Liu, XP Huang, KM White, ... Frontiers in Pharmacology 12, 633680, 2021 | 154 | 2021 |
Varicella-zoster virus immediate-early protein 62 blocks interferon regulatory factor 3 (IRF3) phosphorylation at key serine residues: a novel mechanism of IRF3 inhibition … N Sen, M Sommer, X Che, K White, WT Ruyechan, AM Arvin Journal of virology 84 (18), 9240-9253, 2010 | 104 | 2010 |
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication SK Kuss-Duerkop, J Wang, I Mena, K White, G Metreveli, R Sakthivel, ... PLoS pathogens 13 (9), e1006635, 2017 | 98 | 2017 |
TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation JSY Ho, BWY Mok, L Campisi, T Jordan, S Yildiz, S Parameswaran, ... Cell 184 (10), 2618-2632. e17, 2021 | 94 | 2021 |
A large-scale drug repositioning survey for SARS-CoV-2 antivirals L Riva, S Yuan, X Yin, L Martin-Sancho, N Matsunaga, ... BioRxiv, 2020.04. 16.044016, 2020 | 92 | 2020 |
An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation M Schoof, B Faust, RA Saunders, S Sangwan, V Rezelj, N Hoppe, ... BioRxiv, 2020 | 66 | 2020 |
Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture K Bafna, K White, B Harish, R Rosales, TA Ramelot, TB Acton, E Moreno, ... Cell reports 35 (7), 2021 | 64 | 2021 |