| Isothermal titration calorimetry to determine association constants for high-affinity ligands A Velazquez-Campoy, E Freire Nature Protocols 1 (1), 186, 2006 | 357 | 2006 |
| Isothermal titration calorimetry A Velázquez-Campoy, H Ohtaka, A Nezami, S Muzammil, E Freire Current Protocols in Cell Biology, Unit 17.8, 2004 | 348 | 2004 |
| ITC in the post-genomic era…? Priceless AV Campoy, E Freire Biophysical Chemistry 115 (2), 115-124, 2005 | 278 | 2005 |
| Characterization of protein-protein interactions by isothermal titration calorimetry A Velazquez-Campoy, SA Leavitt, E Freire Methods in Molecular Biology 261, 35-54, 2004 | 275 | 2004 |
| Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro U Bacha, J Barrila, A Velazquez-Campoy, SA Leavitt, E Freire Biochemistry 43 (17), 4906-4912, 2004 | 271 | 2004 |
| Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening O Abian, D Ortega-Alarcon, A Jimenez-Alesanco, L Ceballos-Laita, ... International Journal of Biological Macromolecules 164, 1693-1703, 2020 | 270 | 2020 |
| The binding energetics of first-and second-generation HIV-1 protease inhibitors: implications for drug design A Velazquez-Campoy, Y Kiso, E Freire Archives of Biochemistry and Biophysics 390 (2), 169-175, 2001 | 216 | 2001 |
| Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria AL Pey, M Ying, N Cremades, A Velazquez-Campoy, T Scherer, B Thöny, ... The Journal of Clinical Investigation 118 (8), 2858, 2008 | 197 | 2008 |
| Isothermal titration calorimetry: general formalism using binding polynomials E Freire, A Schön, A Velazquez‐Campoy Methods in Enzymology 455, 127-155, 2009 | 196 | 2009 |
| Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes A Velazquez-Campoy, MJ Todd, S Vega, E Freire Proceedings of the National Academy of Sciences 98 (11), 6062-6067, 2001 | 195 | 2001 |
| Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity R Sant'Anna, P Gallego, LZ Robinson, A Pereira-Henriques, N Ferreira, ... Nature Communications 7, 10787, 2016 | 173 | 2016 |
| HIV-1 protease inhibitors: enthalpic versus entropic optimization of the binding affinity A Velazquez-Campoy, MJ Todd, E Freire Biochemistry 39 (9), 2201-2207, 2000 | 168 | 2000 |
| Overcoming drug resistance in HIV‐1 chemotherapy: the binding thermodynamics of Amprenavir and TMC‐126 to wild‐type and drug‐resistant mutants of the HIV‐1 protease H Ohtaka, A Velázquez‐Campoy, D Xie, E Freire Protein Science 11 (8), 1908-1916, 2002 | 165 | 2002 |
| Thermodynamic basis of resistance to HIV-1 protease inhibition: calorimetric analysis of the V82F/I84V active site resistant mutant MJ Todd, I Luque, A Velázquez-Campoy, E Freire Biochemistry 39 (39), 11876-11883, 2000 | 156 | 2000 |
| Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma JL Neira, J Bintz, M Arruebo, B Rizzuti, T Bonacci, S Vega, A Lanas, ... Scientific Reports 7, 39732, 2017 | 134 | 2017 |
| Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition CA Elena-Real, A Díaz-Quintana, K González-Arzola, ... Cell Death & Disease 9 (3), 365, 2018 | 127 | 2018 |
| Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes A Velazquez-Campoy, S Vega, E Freire Biochemistry 41 (27), 8613-8619, 2002 | 123 | 2002 |
| Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions I Moukadiri, S Prado, J Piera, A Velázquez-Campoy, GR Björk, ... Nucleic Acids Research 37 (21), 7177-7193, 2009 | 121 | 2009 |
| Thermodynamic dissection of the binding energetics of KNI-272, a potent HIV-1 protease inhibitor A Velazquez-Campoy, I Luque, MJ Todd, M Milutinovich, Y Kiso, E Freire Protein Science 9 (9), 1801-1809, 2000 | 119 | 2000 |
| Targeting intrinsically disordered proteins involved in cancer P Santofimia-Castaño, B Rizzuti, Y Xia, O Abian, L Peng, ... Cellular and Molecular Life Sciences 77, 1695-1707, 2020 | 102 | 2020 |
