Segui
Simon A. Hinke, Ph.D.
Simon A. Hinke, Ph.D.
Associate Director, Janssen Pharmaceutical Companies of J&J
Email verificata su uw.edu
Titolo
Citata da
Citata da
Anno
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors
T Hansotia, LL Baggio, D Delmeire, SA Hinke, Y Yamada, K Tsukiyama, ...
Diabetes 53 (5), 1326-1335, 2004
3782004
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1
SA Hinke, K Kühn-Wache, T Hoffmann, RA Pederson, CHS McIntosh, ...
Biochemical and biophysical research communications 291 (5), 1302-1308, 2002
2132002
Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon: characterization of glucagon degradation products and DPIV-resistant analogs
SA Hinke, JA Pospisilik, HU Demuth, S Mannhart, K Kuhn-Wache, ...
Journal of Biological Chemistry 275 (6), 3827-3834, 2000
1592000
Glucose suppresses superoxide generation in metabolically responsive pancreatic β cells
GA Martens, Y Cai, S Hinke, G Stangé, M Van de Casteele, D Pipeleers
Journal of biological chemistry 280 (21), 20389-20396, 2005
1532005
Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis
N Pamir, FC Lynn, AMJ Buchan, J Ehses, SA Hinke, JA Pospisilik, ...
American Journal of Physiology-Endocrinology and Metabolism 284 (5), E931-E939, 2003
1532003
Dipeptidyl peptidase IV-resistant [D-Ala2] glucose-dependent insulinotropic polypeptide (GIP) improves glucose tolerance in normal and obese diabetic rats
SA Hinke, RW Gelling, RA Pederson, S Manhart, C Nian, HU Demuth, ...
Diabetes 51 (3), 652-661, 2002
1532002
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1
D Delmeire, D Flamez, SA Hinke, JJ Cali, D Pipeleers, F Schuit
Diabetologia 46, 1383-1393, 2003
1372003
Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation
Y Cai, GA Martens, SA Hinke, H Heimberg, D Pipeleers, ...
Free Radical Biology and Medicine 42 (1), 64-78, 2007
1312007
A novel pathway for regulation of glucose‐dependent insulinotropic polypeptide receptor expression in β‐cells
FC Lynn, SA Thompson, JA Pospisilik, JA Ehses, SA Hinke, N Pamir, ...
The FASEB Journal 17 (1), 91-93, 2003
1222003
AKAP150 Contributes to Enhanced Vascular Tone by Facilitating Large-Conductance Ca2+-Activated K+ Channel Remodeling in Hyperglycemia and Diabetes …
MA Nystoriak, M Nieves-Cintrón, PJ Nygren, SA Hinke, CB Nichols, ...
Circulation Research 114 (4), 607-615, 2014
1202014
Metabolism of glucagon by dipeptidyl peptidase IV (CD26)
JA Pospisilik, SA Hinke, RA Pederson, T Hoffmann, F Rosche, ...
Regulatory Peptides 96 (3), 133-141, 2001
1102001
Methyl succinate antagonises biguanide‐induced AMPK‐activation and death of pancreatic β‐cells through restoration of mitochondrial electron transfer
SA Hinke, GA Martens, Y Cai, J Finsi, H Heimberg, D Pipeleers, ...
British journal of pharmacology 150 (8), 1031-1043, 2007
1032007
Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP)
SA Hinke, S Manhart, N Pamir, HU Demuth, RW Gelling, RA Pederson, ...
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2001
972001
Glucose-dependent insulinotropic polypeptide stimulation of lipolysis in differentiated 3T3-L1 cells: wortmannin-sensitive inhibition by insulin
CHS McIntosh, I Bremsak, FC Lynn, R Gill, SA Hinke, R Gelling, C Nian, ...
Endocrinology 140 (1), 398-404, 1999
951999
GIP6–30amide contains the high affinity binding region of GIP and is a potent inhibitor of GIP1–42action in vitro
RW Gelling, DH Coy, RA Pederson, MB Wheeler, S Hinke, T Kwan, ...
Regulatory peptides 69 (3), 151-154, 1997
901997
Plasticity of the β cell insulin secretory competence: preparing the pancreatic β cell for the next meal
SA Hinke, K Hellemans, FC Schuit
The Journal of Physiology 558 (2), 369-380, 2004
792004
Anchored phosphatases modulate glucose homeostasis
SA Hinke, MF Navedo, A Ulman, JL Whiting, PJ Nygren, G Tian, ...
The EMBO journal 31 (20), 3991-4004, 2012
782012
On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors/Response to Hinke et al.
SA Hinke, CHS McIntosh, T Hoffmann, K Kühn-Wache
Diabetes Care 25 (8), 1490, 2002
722002
MyRIP anchors protein kinase A to the exocyst complex
AS Goehring, BS Pedroja, SA Hinke, LK Langeberg, JD Scott
Journal of Biological Chemistry 282 (45), 33155-33167, 2007
572007
Characterization of the carboxyl-terminal domain of the rat glucose-dependent insulinotropic polypeptide (GIP) receptor: a role for serines 426 and 427 in regulating the rate …
MB Wheeler, RW Gelling, SA Hinke, B Tu, RA Pederson, F Lynn, J Ehses, ...
Journal of Biological Chemistry 274 (35), 24593-24601, 1999
491999
Il sistema al momento non può eseguire l'operazione. Riprova più tardi.
Articoli 1–20