| Topological domains in mammalian genomes identified by analysis of chromatin interactions JR Dixon, S Selvaraj, F Yue, A Kim, Y Li, Y Shen, M Hu, JS Liu, B Ren Nature 485 (7398), 376-380, 2012 | 7210 | 2012 |
| Integrative analysis of 111 reference human epigenomes A Kundaje, W Meuleman, J Ernst, M Bilenky, A Yen, A Heravi-Moussavi, ... Nature 518 (7539), 317-330, 2015 | 6312 | 2015 |
| Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project Management Group Liefer Laura A. 51 Wetterstrand Kris A. 51 Good Peter J. 51 ... nature 447 (7146), 799-816, 2007 | 6098 | 2007 |
| Human DNA methylomes at base resolution show widespread epigenomic differences R Lister, M Pelizzola, RH Dowen, RD Hawkins, G Hon, J Tonti-Filippini, ... nature 462 (7271), 315-322, 2009 | 5386 | 2009 |
| Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome ND Heintzman, RK Stuart, G Hon, Y Fu, CW Ching, RD Hawkins, ... Nature genetics 39 (3), 311-318, 2007 | 4024 | 2007 |
| Transcriptional regulatory networks in Saccharomyces cerevisiae TI Lee, NJ Rinaldi, F Robert, DT Odom, Z Bar-Joseph, GK Gerber, ... science 298 (5594), 799-804, 2002 | 3905 | 2002 |
| N6-methyladenosine-dependent regulation of messenger RNA stability X Wang, Z Lu, A Gomez, GC Hon, Y Yue, D Han, Y Fu, M Parisien, Q Dai, ... Nature 505 (7481), 117-120, 2014 | 3801 | 2014 |
| Histone modifications at human enhancers reflect global cell-type-specific gene expression ND Heintzman, GC Hon, RD Hawkins, P Kheradpour, A Stark, LF Harp, ... Nature 459 (7243), 108-112, 2009 | 2952 | 2009 |
| Genome-wide location and function of DNA binding proteins B Ren, F Robert, JJ Wyrick, O Aparicio, EG Jennings, I Simon, J Zeitlinger, ... Science 290 (5500), 2306-2309, 2000 | 2768 | 2000 |
| The ENCODE (ENCyclopedia of DNA elements) project EA Feingold, PJ Good, MS Guyer, S Kamholz, L Liefer, K Wetterstrand, ... Science 306 (5696), 636-640, 2004 | 2437 | 2004 |
| A comparative encyclopedia of DNA elements in the mouse genome F Yue, Y Cheng, A Breschi, J Vierstra, W Wu, T Ryba, R Sandstrom, Z Ma, ... Nature 515 (7527), 355-364, 2014 | 1986 | 2014 |
| ChIP-seq accurately predicts tissue-specific activity of enhancers A Visel, MJ Blow, Z Li, T Zhang, JA Akiyama, A Holt, I Plajzer-Frick, ... Nature 457 (7231), 854-858, 2009 | 1976 | 2009 |
| Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification M Tan, H Luo, S Lee, F Jin, JS Yang, E Montellier, T Buchou, Z Cheng, ... Cell 146 (6), 1016-1028, 2011 | 1941 | 2011 |
| The NIH roadmap epigenomics mapping consortium BE Bernstein, JA Stamatoyannopoulos, JF Costello, B Ren, ... Nature biotechnology 28 (10), 1045-1048, 2010 | 1936 | 2010 |
| Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells R Lister, M Pelizzola, YS Kida, RD Hawkins, JR Nery, G Hon, ... Nature 471 (7336), 68-73, 2011 | 1837 | 2011 |
| Chromatin architecture reorganization during stem cell differentiation JR Dixon, I Jung, S Selvaraj, Y Shen, JE Antosiewicz-Bourget, AY Lee, ... Nature 518 (7539), 331-336, 2015 | 1768 | 2015 |
| Remodeling of yeast genome expression in response to environmental changes HC Causton, B Ren, SS Koh, CT Harbison, E Kanin, EG Jennings, TI Lee, ... Molecular biology of the cell 12 (2), 323-337, 2001 | 1756 | 2001 |
| A map of the cis-regulatory sequences in the mouse genome Y Shen, F Yue, DF McCleary, Z Ye, L Edsall, S Kuan, U Wagner, J Dixon, ... Nature 488 (7409), 116-120, 2012 | 1578 | 2012 |
| Expanded encyclopaedias of DNA elements in the human and mouse genomes JE Moore, MJ Purcaro, HE Pratt, CB Epstein, N Shoresh, J Adrian, T Kawli, ... Nature 583 (7818), 699-710, 2020 | 1426 | 2020 |
| E2F integrates cell cycle progression with DNA repair, replication, and G2/M checkpoints B Ren, H Cam, Y Takahashi, T Volkert, J Terragni, RA Young, ... Genes & development 16 (2), 245-256, 2002 | 1369 | 2002 |