| Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand, MR Vos, GF Schröder, ... Cell 156 (6), 1193-1206, 2014 | 1324 | 2014 |
| Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization L Zhang, S Chen, J Ruan, J Wu, AB Tong, Q Yin, Y Li, L David, A Lu, ... Science 350 (6259), 404-409, 2015 | 430 | 2015 |
| Structural mechanisms of inflammasome assembly A Lu, H Wu The FEBS journal 282 (3), 435-444, 2015 | 249 | 2015 |
| Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex TM Fu, Y Li, A Lu, Z Li, PR Vajjhala, AC Cruz, DB Srivastava, F DiMaio, ... Molecular Cell 64 (2), 236-250, 2016 | 182 | 2016 |
| Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism A Lu, Y Li, FI Schmidt, Q Yin, S Chen, TM Fu, AB Tong, HL Ploegh, Y Mao, ... Nature structural & molecular biology 23 (5), 416-425, 2016 | 171 | 2016 |
| A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly FI Schmidt, A Lu, JW Chen, J Ruan, C Tang, H Wu, HL Ploegh Journal of Experimental Medicine 213 (5), 771-790, 2016 | 168 | 2016 |
| Structural and functional studies of Aspergillus oryzae cutinase: enhanced thermostability and hydrolytic activity of synthetic ester and polyester degradation Z Liu, Y Gosser, PJ Baker, Y Ravee, Z Lu, G Alemu, H Li, GL Butterfoss, ... Journal of the American Chemical Society 131 (43), 15711-15716, 2009 | 147 | 2009 |
| Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 Y Li, TM Fu, A Lu, K Witt, J Ruan, C Shen, H Wu Proceedings of the National Academy of Sciences 115 (43), 10845-10852, 2018 | 128 | 2018 |
| SERPINB1-mediated checkpoint of inflammatory caspase activation YJ Choi, S Kim, Y Choi, TB Nielsen, J Yan, A Lu, J Ruan, HR Lee, H Wu, ... Nature immunology 20 (3), 276-287, 2019 | 108 | 2019 |
| PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity JM Gozgit, MM Vasbinder, RP Abo, K Kunii, KG Kuplast-Barr, B Gui, AZ Lu, ... Cancer Cell 39 (9), 1214-1226. e10, 2021 | 107 | 2021 |
| Molecular mechanism for NLRP6 inflammasome assembly and activation C Shen, A Lu, WJ Xie, J Ruan, R Negro, EH Egelman, TM Fu, H Wu Proceedings of the National Academy of Sciences 116 (6), 2052-2057, 2019 | 104 | 2019 |
| Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation Q Yin, DP Sester, Y Tian, YS Hsiao, A Lu, JA Cridland, V Sagulenko, ... Cell reports 4 (2), 327-339, 2013 | 99 | 2013 |
| Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2 A Lu, Y Li, Q Yin, J Ruan, X Yu, E Egelman, H Wu Cell discovery 1 (1), 1-14, 2015 | 96 | 2015 |
| The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments PR Vajjhala, A Lu, DL Brown, SW Pang, V Sagulenko, DP Sester, ... Journal of Biological Chemistry 290 (49), 29217-29230, 2015 | 92 | 2015 |
| Heat shock protein 70 inhibitors. 2. 2, 5′-thiodipyrimidines, 5-(phenylthio) pyrimidines, 2-(pyridin-3-ylthio) pyrimidines, and 3-(phenylthio) pyridines as reversible binders … T Taldone, Y Kang, HJ Patel, MR Patel, PD Patel, A Rodina, Y Patel, ... Journal of medicinal chemistry 57 (4), 1208-1224, 2014 | 69 | 2014 |
| Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions A Lu, V Kabaleeswaran, T Fu, VG Magupalli, H Wu Journal of molecular biology 426 (7), 1420-1427, 2014 | 59 | 2014 |
| A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants LB Schenkel, JR Molina, KK Swinger, R Abo, DJ Blackwell, AZ Lu, ... Cell Chemical Biology 28 (8), 1158-1168. e13, 2021 | 52 | 2021 |
| Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation AZ Lu, R Abo, Y Ren, B Gui, JR Mo, D Blackwell, T Wigle, H Keilhack, ... Biochemical pharmacology 167, 97-106, 2019 | 44 | 2019 |
| Instant Hydrogelation Inspired by Inflammasomes H Wang, Z Feng, A Lu, Y Jiang, H Wu, B Xu Angewandte Chemie 129 (26), 7687-7691, 2017 | 25 | 2017 |
| In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement TJ Wigle, DJ Blackwell, LB Schenkel, Y Ren, WD Church, HJ Desai, ... Cell Chemical Biology 27 (7), 877-887. e14, 2020 | 22 | 2020 |
