| Metabolic engineering: principles and methodologies G Stephanopoulos, AA Aristidou, J Nielsen Elsevier, 1998 | 2149 | 1998 |
| Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia CM Metallo, PA Gameiro, EL Bell, KR Mattaini, J Yang, K Hiller, ... Nature 481 (7381), 380-384, 2012 | 1987 | 2012 |
| Engineering cell shape and function R Singhvi, A Kumar, GP Lopez, GN Stephanopoulos, DIC Wang, ... Science 264 (5159), 696-698, 1994 | 1958 | 1994 |
| Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli PK Ajikumar, WH Xiao, KEJ Tyo, Y Wang, F Simeon, E Leonard, O Mucha, ... Science 330 (6000), 70-74, 2010 | 1956 | 2010 |
| Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ... Nature genetics 43 (9), 869-874, 2011 | 1207 | 2011 |
| Tuning genetic control through promoter engineering H Alper, C Fischer, E Nevoigt, G Stephanopoulos Proceedings of the National Academy of Sciences 102 (36), 12678-12683, 2005 | 1120 | 2005 |
| Engineering yeast transcription machinery for improved ethanol tolerance and production H Alper, J Moxley, E Nevoigt, GR Fink, G Stephanopoulos Science 314 (5805), 1565-1568, 2006 | 1023 | 2006 |
| Challenges in engineering microbes for biofuels production G Stephanopoulos Science 315 (5813), 801-804, 2007 | 948 | 2007 |
| Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 809 | 2012 |
| Metabolic fluxes and metabolic engineering G Stephanopoulos Metabolic engineering 1 (1), 1-11, 1999 | 805 | 1999 |
| Transcriptional control of autophagy–lysosome function drives pancreatic cancer metabolism RM Perera, S Stoykova, BN Nicolay, KN Ross, J Fitamant, M Boukhali, ... Nature 524 (7565), 361-365, 2015 | 798 | 2015 |
| Network rigidity and metabolic engineering in metabolite overproduction G Stephanopoulos, JJ Vallino Science 252 (5013), 1675-1681, 1991 | 742 | 1991 |
| Distributing a metabolic pathway among a microbial consortium enhances production of natural products K Zhou, K Qiao, S Edgar, G Stephanopoulos Nature biotechnology 33 (4), 377-383, 2015 | 728 | 2015 |
| Engineering the push and pull of lipid biosynthesis in oleaginous yeast Yarrowia lipolytica for biofuel production M Tai, G Stephanopoulos Metabolic engineering 15, 1-9, 2013 | 716 | 2013 |
| The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 A Csibi, SM Fendt, C Li, G Poulogiannis, AY Choo, DJ Chapski, SM Jeong, ... Cell 153 (4), 840-854, 2013 | 696 | 2013 |
| Metabolic flux distributions in Corynebacterium glutamicum during growth and lysine overproduction JJ Vallino, G Stephanopoulos Biotechnology and bioengineering 67 (6), 872-885, 2000 | 682 | 2000 |
| Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions MR Antoniewicz, JK Kelleher, G Stephanopoulos Metabolic engineering 9 (1), 68-86, 2007 | 663 | 2007 |
| A roadmap for interpreting 13C metabolite labeling patterns from cells JM Buescher, MR Antoniewicz, LG Boros, SC Burgess, H Brunengraber, ... Current opinion in biotechnology 34, 189-201, 2015 | 645 | 2015 |
| Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth D Gaglio, CM Metallo, PA Gameiro, K Hiller, LS Danna, C Balestrieri, ... Molecular systems biology 7 (1), 523, 2011 | 587 | 2011 |
| Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis SB Biddinger, A Hernandez-Ono, C Rask-Madsen, JT Haas, JO Alemán, ... Cell metabolism 7 (2), 125-134, 2008 | 581 | 2008 |
Hal AlperProfessor, Chemical Engineering, The University of Texas at AustinEmail verificata su che.utexas.edu