| Mutation effects predicted from sequence co-variation TA Hopf, JB Ingraham, FJ Poelwijk, CPI Schärfe, M Springer, C Sander, ... Nature biotechnology 35 (2), 128-135, 2017 | 674 | 2017 |
| Empirical fitness landscapes reveal accessible evolutionary paths FJ Poelwijk, DJ Kiviet, DM Weinreich, SJ Tans Nature 445 (7126), 383-386, 2007 | 615 | 2007 |
| The spatial architecture of protein function and adaptation RN McLaughlin Jr, FJ Poelwijk, A Raman, WS Gosal, R Ranganathan Nature 491 (7422), 138-142, 2012 | 530 | 2012 |
| Illuminating protein space with a programmable generative model JB Ingraham, M Baranov, Z Costello, KW Barber, W Wang, A Ismail, ... Nature 623 (7989), 1070-1078, 2023 | 293 | 2023 |
| Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes FJ Poelwijk, S Tănase-Nicola, DJ Kiviet, SJ Tans Journal of theoretical biology 272 (1), 141-144, 2011 | 246 | 2011 |
| Learning the pattern of epistasis linking genotype and phenotype in a protein FJ Poelwijk, M Socolich, R Ranganathan Nature communications 10 (1), 4213, 2019 | 160 | 2019 |
| Inferring protein 3D structure from deep mutation scans. NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ... Nature Genetics 51 (7), 1170-1176, 2019 | 159 | 2019 |
| LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function SR Holmstrom, T Deering, GH Swift, FJ Poelwijk, DJ Mangelsdorf, ... Genes & development 25 (16), 1674-1679, 2011 | 134 | 2011 |
| Tradeoffs and optimality in the evolution of gene regulation FJ Poelwijk, MGJ de Vos, SJ Tans Cell 146 (3), 462-470, 2011 | 128 | 2011 |
| The Context-Dependence of Mutations: A Linkage of Formalisms FJ Poelwijk, V Krishna, R Ranganathan PLoS Computational Biology 12 (6), e1004771, 2016 | 115 | 2016 |
| Dynamics of a random laser above threshold G van Soest, FJ Poelwijk, R Sprik, A Lagendijk Physical Review Letters 86 (8), 1522, 2001 | 104 | 2001 |
| Photon correlation spectroscopy: X rays versus visible light DO Riese, WL Vos, GH Wegdam, FJ Poelwijk, DL Abernathy, G Grübel Physical Review E 61 (2), 1676, 2000 | 67 | 2000 |
| Environmental dependence of genetic constraint MGJ de Vos, FJ Poelwijk, N Battich, JDT Ndika, SJ Tans PLoS genetics 9 (6), e1003580, 2013 | 59 | 2013 |
| Evolutionary potential of a duplicated repressor-operator pair: simulating pathways using mutation data FJ Poelwijk, DJ Kiviet, SJ Tans PLoS computational biology 2 (5), e58, 2006 | 53 | 2006 |
| Mutant Cas9 proteins A Chavez, F Poelwijk, GM Church US Patent 9,074,199, 2015 | 51 | 2015 |
| Protein structure from experimental evolution MA Stiffler, FJ Poelwijk, KP Brock, RR Stein, A Riesselman, J Teyra, ... Cell Systems 10 (1), 15-24. e5, 2020 | 42 | 2020 |
| Mutant Cas9 proteins A Chavez, F Poelwijk, GM Church US Patent 10,100,291, 2018 | 42 | 2018 |
| Quantification of the effect of mutations using a global probability model of natural sequence variation TA Hopf, JB Ingraham, FJ Poelwijk, M Springer, C Sander, DS Marks arXiv preprint arXiv:1510.04612, 2015 | 40 | 2015 |
| Speckle experiments in random lasers G Van Soest, FJ Poelwijk, A Lagendijk Physical Review E 65 (4), 046603, 2002 | 36 | 2002 |
| Optimality and evolution of transcriptionally regulated gene expression FJ Poelwijk, PD Heyning, MGJ de Vos, DJ Kiviet, SJ Tans BMC systems biology 5, 1-12, 2011 | 32 | 2011 |