| Structure of the PilM-PilN inner membrane type IV pilus biogenesis complex from Thermus thermophilus V Karuppiah, JP Derrick Journal of Biological Chemistry 286 (27), 24434-24442, 2011 | 104 | 2011 |
| Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ... Acs Catalysis 7 (9), 6268-6282, 2017 | 73 | 2017 |
| Structure and assembly of an inner membrane platform for initiation of type IV pilus biogenesis V Karuppiah, RF Collins, A Thistlethwaite, Y Gao, JP Derrick Proceedings of the National Academy of Sciences 110 (48), E4638-E4647, 2013 | 67 | 2013 |
| Structure and oligomerization of the PilC type IV pilus biogenesis protein from Thermus thermophilus V Karuppiah, D Hassan, M Saleem, JP Derrick Proteins: Structure, Function, and Bioinformatics 78 (9), 2049-2057, 2010 | 61 | 2010 |
| Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen A Poole, V Karuppiah, A Hartt, JN Haidar, S Moureau, T Dobrzycki, ... Nature communications 13 (1), 5333, 2022 | 49 | 2022 |
| Biocatalytic routes to lactone monomers for polymer production HL Messiha, ST Ahmed, V Karuppiah, R Suardíaz, GA Ascue Avalos, ... Biochemistry 57 (13), 1997-2008, 2018 | 48 | 2018 |
| Neuronal calcium sensor-1 binds the D2 dopamine receptor and G-protein-coupled receptor kinase 1 (GRK1) peptides using different modes of interactions S Pandalaneni, V Karuppiah, M Saleem, LP Haynes, RD Burgoyne, ... Journal of Biological Chemistry 290 (30), 18744-18756, 2015 | 41 | 2015 |
| Structure of the Cannabis sativa olivetol‐producing enzyme reveals cyclization plasticity in type III polyketide synthases LJ Kearsey, N Prandi, V Karuppiah, C Yan, D Leys, H Toogood, E Takano, ... The FEBS Journal 287 (8), 1511-1524, 2020 | 39 | 2020 |
| Experiment and simulation reveal how mutations in functional plasticity regions guide plant monoterpene synthase product outcome NGH Leferink, KE Ranaghan, V Karuppiah, A Currin, MW Van Der Kamp, ... ACS catalysis 8 (5), 3780-3791, 2018 | 38 | 2018 |
| Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short‐Chain Dehydrogenases/Reductases A Lygidakis, V Karuppiah, R Hoeven, A Ní Cheallaigh, D Leys, ... Angewandte Chemie 128 (33), 9748-9752, 2016 | 36 | 2016 |
| Structure and mechanism of the PilF DNA transformation ATPase from Thermus thermophilus RF Collins, D Hassan, V Karuppiah, A Thistlethwaite, JP Derrick Biochemical Journal 450 (2), 417-425, 2013 | 30 | 2013 |
| Structural cycle of the Thermus thermophilus PilF ATPase: the powering of type IVa pilus assembly R Collins, V Karuppiah, CA Siebert, R Dajani, A Thistlethwaite, JP Derrick Scientific Reports 8 (1), 14022, 2018 | 27 | 2018 |
| Structural insights into the ene-reductase synthesis of profens J Waller, HS Toogood, V Karuppiah, NJW Rattray, DJ Mansell, D Leys, ... Organic & Biomolecular Chemistry 15 (20), 4440-4448, 2017 | 26 | 2017 |
| Outer membrane translocons: structural insights into channel formation V Karuppiah, JL Berry, JP Derrick Trends in Microbiology 19 (1), 40-48, 2011 | 24 | 2011 |
| Structure and properties of a natural competence-associated pilin suggest a unique pilus tip-associated DNA receptor MZ Salleh, V Karuppiah, M Snee, A Thistlethwaite, CW Levy, D Knight, ... MBio 10 (3), 10.1128/mbio. 00614-19, 2019 | 23 | 2019 |
| Structure and mechanism of the bifunctional CinA enzyme from Thermus thermophilus V Karuppiah, A Thistlethwaite, R Dajani, J Warwicker, JP Derrick Journal of Biological Chemistry 289 (48), 33187-33197, 2014 | 16 | 2014 |
| Structures of type IV pilins from Thermus thermophilus demonstrate similarities with type II secretion system pseudopilins V Karuppiah, A Thistlethwaite, JP Derrick Journal of Structural Biology 196 (3), 375-384, 2016 | 15 | 2016 |
| Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition C Barber, VA De Souza, RL Paterson, M Martin‐Urdiroz, NC Mulakkal, ... European Journal of Immunology 52 (4), 618-632, 2022 | 12 | 2022 |
| Promiscuous recognition of MR1 drives self-reactive mucosal-associated invariant T cell responses A Chancellor, R Alan Simmons, RC Khanolkar, V Nosi, A Beshirova, ... Journal of Experimental Medicine 220 (9), e20221939, 2023 | 8 | 2023 |
| Type IV pili—a numbers game V Karuppiah, JP Derrick The EMBO Journal 33 (16), 1732-1734, 2014 | 2 | 2014 |
Nigel ScruttonProfessor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of ChemistryEmail verificata su manchester.ac.uk