| Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-β pathways C Alarcón, AI Zaromytidou, Q Xi, S Gao, J Yu, S Fujisawa, A Barlas, ... Cell 139 (4), 757-769, 2009 | 846 | 2009 |
| Reduction of nitrite to nitric oxide catalyzed by xanthine oxidoreductase BLJ Godber, JJ Doel, GP Sapkota, DR Blake, CR Stevens, R Eisenthal, ... Journal of Biological Chemistry 275 (11), 7757-7763, 2000 | 526 | 2000 |
| Balancing BMP signaling through integrated inputs into the Smad1 linker G Sapkota, C Alarcón, FM Spagnoli, AH Brivanlou, J Massagué Molecular cell 25 (3), 441-454, 2007 | 487 | 2007 |
| Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD AF Baas, J Boudeau, GP Sapkota, L Smit, R Medema, NA Morrice, ... The EMBO journal, 2003 | 481 | 2003 |
| Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-β signaling S Gao, C Alarcón, G Sapkota, S Rahman, PY Chen, N Goerner, ... Molecular cell 36 (3), 457-468, 2009 | 427 | 2009 |
| Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis MJ Lee, S Thangada, JH Paik, GP Sapkota, N Ancellin, SS Chae, M Wu, ... Molecular cell 8 (3), 693-704, 2001 | 385 | 2001 |
| BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo GP Sapkota, L Cummings, FS Newell, C Armstrong, J Bain, M Frodin, ... Biochemical Journal 401 (1), 29-38, 2007 | 351 | 2007 |
| Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent protein kinase, but not its farnesylation at … GP Sapkota, A Kieloch, JM Lizcano, S Lain, JSC Arthur, MR Williams, ... Journal of Biological Chemistry 276 (22), 19469-19482, 2001 | 323 | 2001 |
| The specificities of small molecule inhibitors of the TGFss and BMP pathways J Vogt, R Traynor, GP Sapkota Cellular signalling 23 (11), 1831-1842, 2011 | 321 | 2011 |
| LKB1, a protein kinase regulating cell proliferation and polarity J Boudeau, G Sapkota, DR Alessi FEBS letters 546 (1), 159-165, 2003 | 254 | 2003 |
| Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase P Douglas, GP Sapkota, N Morrice, Y Yu, AA Goodarzi, D Merkle, K Meek, ... Biochemical Journal 368 (1), 243-251, 2002 | 254 | 2002 |
| Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming … G Sapkota, M Knockaert, C Alarcón, E Montalvo, AH Brivanlou, ... Journal of Biological Chemistry 281 (52), 40412-40419, 2006 | 211 | 2006 |
| Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling M Knockaert, G Sapkota, C Alarcón, J Massagué, AH Brivanlou Proceedings of the National Academy of Sciences 103 (32), 11940-11945, 2006 | 173 | 2006 |
| TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition A Ramachandran, P Vizan, D Das, P Chakravarty, J Vogt, KW Rogers, ... Elife 7, e31756, 2018 | 166 | 2018 |
| Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366 GP Sapkota, M Deak, A Kieloch, N Morrice, AA Goodarzi, C Smythe, ... Biochemical Journal 368 (2), 507-516, 2002 | 157 | 2002 |
| OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3 L Herhaus, M Al-Salihi, T Macartney, S Weidlich, GP Sapkota Nature communications 4 (1), 2519, 2013 | 142 | 2013 |
| USP11 augments TGFβ signalling by deubiquitylating ALK5 MA Al-Salihi, L Herhaus, T Macartney, GP Sapkota Open biology 2 (6), 120063, 2012 | 139 | 2012 |
| Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz–Jeghers cancer … GP Sapkota, J Boudeau, M Deak, A Kieloch, N Morrice, DR Alessi Biochemical journal 362 (2), 481-490, 2002 | 138 | 2002 |
| Phosphatases in SMAD regulation DL Bruce, GP Sapkota FEBS letters 586 (14), 1897-1905, 2012 | 115 | 2012 |
| Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma P Cammareri, AM Rose, DF Vincent, J Wang, A Nagano, S Libertini, ... Nature communications 7 (1), 12493, 2016 | 107 | 2016 |
