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Eugene Hickey
Eugene Hickey
Schrödinger, LLC
Email verificata su schrodinger.com
Titolo
Citata da
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Anno
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
C Pargellis, L Tong, L Churchill, PF Cirillo, T Gilmore, AG Graham, ...
Nature structural biology 9 (4), 268-272, 2002
10702002
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
S Kubicek, RJ O'Sullivan, EM August, ER Hickey, Q Zhang, ML Teodoro, ...
Molecular cell 25 (3), 473-481, 2007
9552007
Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate
J Regan, S Breitfelder, P Cirillo, T Gilmore, AG Graham, E Hickey, B Klaus, ...
Journal of medicinal chemistry 45 (14), 2994-3008, 2002
4342002
Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase
KC Qian, L Wang, ER Hickey, J Studts, K Barringer, C Peng, A Kronkaitis, ...
Journal of Biological Chemistry 280 (7), 6130-6137, 2005
3302005
Structure−Activity Relationships of the p38α MAP Kinase Inhibitor 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea …
J Regan, A Capolino, PF Cirillo, T Gilmore, AG Graham, E Hickey, ...
Journal of medicinal chemistry 46 (22), 4676-4686, 2003
1682003
Aromatic heterocyclic compound as antiinflammatory agents
PF Cirillo, TA Gilmore, ER Hickey, JR Regan, LH Zhang
US Patent 6,319,921, 2001
1552001
The kinetics of binding to p38 MAP kinase by analogues of BIRB 796
J Regan, CA Pargellis, PF Cirillo, T Gilmore, ER Hickey, GW Peet, A Proto, ...
Bioorganic & medicinal chemistry letters 13 (18), 3101-3104, 2003
1292003
Aromatic heterocyclic compounds and their use as anti-inflammatory agents
JR Regan, PF Cirillo, ER Hickey, N Moss, CL Cywin, C Pargellis, ...
US Patent 6,080,763, 2000
1002000
Compounds useful as anti-inflammatory agents
S Breitfelder, PF Cirillo, TA Gilmore, ER Hickey, JR Proudfoot, JR Regan, ...
US Patent 6,358,945, 2002
982002
Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode
K Qian, L Wang, CL Cywin, BT Farmer, E Hickey, C Homon, S Jakes, ...
Journal of medicinal chemistry 52 (7), 1814-1827, 2009
822009
Ligands for the Tyrosine Kinase p56lck SH2 Domain:  Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements
PL Beaulieu, DR Cameron, JM Ferland, J Gauthier, E Ghiro, J Gillard, ...
Journal of medicinal chemistry 42 (10), 1757-1766, 1999
791999
Direct elaboration of complex polyquinanes through twofold addition of vinyl anions to squarate esters
J Negri, T Morwick, J Doyon, PD Wilson, ER Hickey, LA Paquette
Journal of the American Chemical Society 115 (25), 12189-12190, 1993
781993
Compounds which modulate the CB2 receptor
R Zindell, D Riether, DS Thomson, ER Hickey, I Mushi, M Ermann
US Patent 7,595,397, 2009
752009
An in silico method for predicting Ames activities of primary aromatic amines by calculating the stabilities of nitrenium ions
J Bentzien, ER Hickey, RA Kemper, ML Brewer, JD Dyekjær, SP East, ...
Journal of chemical information and modeling 50 (2), 274-297, 2010
732010
A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo
ND Lewis, LA Patnaude, J Pelletier, DJ Souza, SM Lukas, FJ King, JD Hill, ...
PLoS One 9 (6), e100883, 2014
722014
Isoquinolinone Rho kinase inhibitors
T Bosanac, JD Ginn, ER Hickey, TM Kirrane Jr, W Liu, AS Prokopowicz, ...
US Patent 8,809,326, 2014
712014
Compounds useful as anti-inflammatory agents
S Breitfelder, PF Cirillo, MH Hao, ER Hickey, R Sharma, S Sun, ...
US Patent 6,492,393, 2002
632002
G Protein–Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a KCa1. 1 (BKCa)–Dependent Mechanism
RM Fryer, KJ Ng, SGN Mazurek, L Patnaude, DJ Skow, A Muthukumarana, ...
Journal of Pharmacology and Experimental Therapeutics 348 (3), 421-431, 2014
542014
Compounds which modulate the CB2 receptor
A Berry, PF Cirillo, D Riether, D Thomson, RM Zindell, N Blumire, ...
US Patent 7,928,123, 2011
502011
Aromatic heterocyclic compounds as antiinflammatory agents
P Cirillo, T Gilmore, E Hickey, J Regan, LH Zhang
US Patent App. 09/879,776, 2002
472002
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