| Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor N Sato, L Meijer, L Skaltsounis, P Greengard, AH Brivanlou Nature medicine 10 (1), 55-63, 2004 | 2646 | 2004 |
| Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin‐dependent kinases cdc2, cdk2 and cdk5 L Meijer, A Borgne, O Mulner, JPJ Chong, JJ Blow, N Inagaki, M Inagaki, ... European journal of biochemistry 243 (1‐2), 527-536, 1997 | 1634 | 1997 |
| Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors NS Gray, L Wodicka, AMWH Thunnissen, TC Norman, S Kwon, ... Science 281 (5376), 533-538, 1998 | 1142 | 1998 |
| Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases R Hoessel, S Leclerc, JA Endicott, MEM Nobel, A Lawrie, P Tunnah, ... Nature cell biology 1 (1), 60-67, 1999 | 1050 | 1999 |
| GSK-3-selective inhibitors derived from Tyrian purple indirubins L Meijer, AL Skaltsounis, P Magiatis, P Polychronopoulos, M Knockaert, ... Chemistry & biology 10 (12), 1255-1266, 2003 | 976 | 2003 |
| Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease: A PROPERTY COMMON TO MOST … S Leclerc, M Garnier, R Hoessel, D Marko, JA Bibb, GL Snyder, ... Journal of Biological Chemistry 276 (1), 251-260, 2001 | 945 | 2001 |
| Inhibition of cyclin‐dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine WF De Azevedo, S Leclerc, L Meijer, L Havlicek, M Strnad, SH Kim European journal of biochemistry 243 (1‐2), 518-526, 1997 | 907 | 1997 |
| Inhibition of cyclin‐dependent kinases by purine analogues J Veselý, L Havliček, M Strnad, JJ Blow, A Donella‐Deana, L Pinna, ... European journal of biochemistry 224 (2), 771-786, 1994 | 812 | 1994 |
| Pharmacological inhibitors of glycogen synthase kinase 3 L Meijer, M Flajolet, P Greengard Trends in pharmacological sciences 25 (9), 471-480, 2004 | 760 | 2004 |
| Constitutive phosphorylation of the Parkinson's disease associated α-synuclein M Okochi, J Walter, A Koyama, S Nakajo, M Baba, T Iwatsubo, L Meijer, ... Journal of Biological Chemistry 275 (1), 390-397, 2000 | 734 | 2000 |
| Pharmacological inhibitors of cyclin-dependent kinases M Knockaert, P Greengard, L Meijer Trends in pharmacological sciences 23 (9), 417-425, 2002 | 731 | 2002 |
| cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF D Arion, L Meijer, L Brizuela, D Beach Cell 55 (2), 371-378, 1988 | 706 | 1988 |
| Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons JA Bibb, GL Snyder, A Nishi, Z Yan, L Meijer, AA Fienberg, LH Tsai, ... Nature 402 (6762), 669-671, 1999 | 674 | 1999 |
| Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent L Meijer, AMWH Thunnissen, AW White, M Garnier, M Nikolic, LH Tsai, ... Chemistry & biology 7 (1), 51-63, 2000 | 600 | 2000 |
| Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25 M Leost, C Schultz, A Link, YZ Wu, J Biernat, EM Mandelkow, JA Bibb, ... European journal of biochemistry 267 (19), 5983-5994, 2000 | 500 | 2000 |
| Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases SM Sondhi, N Singh, A Kumar, O Lozach, L Meijer Bioorganic & medicinal chemistry 14 (11), 3758-3765, 2006 | 493 | 2006 |
| Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases P Polychronopoulos, P Magiatis, AL Skaltsounis, V Myrianthopoulos, ... Journal of medicinal chemistry 47 (4), 935-946, 2004 | 491 | 2004 |
| Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials L Meijer, E Raymond Accounts of chemical research 36 (6), 417-425, 2003 | 484 | 2003 |
| Roscovitine Targets, Protein Kinases and Pyridoxal Kinase*[Boxs] S Bach, M Knockaert, J Reinhardt, O Lozach, S Schmitt, B Baratte, ... Journal of Biological Chemistry 280 (35), 31208-31219, 2005 | 437 | 2005 |
| Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity C Schultz, A Link, M Leost, DW Zaharevitz, R Gussio, EA Sausville, ... Journal of medicinal chemistry 42 (15), 2909-2919, 1999 | 409 | 1999 |
