| The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. CG Begley, PD Aplan, SM Denning, BF Haynes, TA Waldmann, IR Kirsch Proceedings of the National Academy of Sciences 86 (24), 10128-10132, 1989 | 461 | 1989 |
| Genome organization drives chromosome fragility A Canela, Y Maman, S Jung, N Wong, E Callen, A Day, KR Kieffer-Kwon, ... Cell 170 (3), 507-521. e18, 2017 | 392 | 2017 |
| Chromosomal translocation in a human leukemic stem-cell line disrupts the T-cell antigen receptor delta-chain diversity region and results in a previously unreported fusion … CG Begley, PD Aplan, MP Davey, K Nakahara, K Tchorz, J Kurtzberg, ... Proceedings of the National Academy of Sciences 86 (6), 2031-2035, 1989 | 369 | 1989 |
| Disruption of the human SCL locus by" illegitimate" V-(D)-J recombinase activity PD Aplan, DP Lombardi, AM Ginsberg, J Cossman, VL Bertness, ... Science 250 (4986), 1426-1429, 1990 | 347 | 1990 |
| NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights SM Gough, CI Slape, PD Aplan Blood, The Journal of the American Society of Hematology 118 (24), 6247-6257, 2011 | 346 | 2011 |
| A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia RJ Jaju, C Fidler, OA Haas, AJ Strickson, F Watkins, K Clark, NCP Cross, ... Blood, The Journal of the American Society of Hematology 98 (4), 1264-1267, 2001 | 284 | 2001 |
| Causes of oncogenic chromosomal translocation PD Aplan TRENDS in Genetics 22 (1), 46-55, 2006 | 278 | 2006 |
| SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression S Herblot, AM Steff, P Hugo, PD Aplan, T Hoang Nature immunology 1 (2), 138-144, 2000 | 275 | 2000 |
| The SCL gene product: a positive regulator of erythroid differentiation. PD Aplan, K Nakahara, SH Orkin, IR Kirsch The EMBO journal 11 (11), 4073-4081, 1992 | 273 | 1992 |
| NUP98-HOXD13 transgenic mice develop a highly penetrant, severe myelodysplastic syndrome that progresses to acute leukemia YW Lin, C Slape, Z Zhang, PD Aplan Blood 106 (1), 287-295, 2005 | 257 | 2005 |
| NUP98-HOXD13 Gene Fusion in Therapy-related Acute Myelogenous Leukemia SZ Raza-Egilmez, SN Jani-Sait, M Grossi, MJ Higgins, TB Shows, ... Cancer research 58 (19), 4269-4273, 1998 | 246 | 1998 |
| Cytogenetics and molecular genetics of acute lymphoblastic leukemia K Mrózek, DP Harper, PD Aplan Hematology/Oncology Clinics 23 (5), 991-1010, 2009 | 231 | 2009 |
| DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis M Stanulla, J Wang, DS Chervinsky, S Thandla, PD Aplan Molecular and cellular biology, 1997 | 224 | 1997 |
| DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier MA Santos, RB Faryabi, AV Ergen, AM Day, A Malhowski, A Canela, ... Nature 514 (7520), 107-111, 2014 | 214 | 2014 |
| Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors [see comments] PD Aplan, DS Chervinsky, M Stanulla, WC Burhans | 208 | 1996 |
| Loss of Smad3 in acute T-cell lymphoblastic leukemia LA Wolfraim, TM Fernandez, M Mamura, WL Fuller, R Kumar, DE Cole, ... New England Journal of Medicine 351 (6), 552-559, 2004 | 203 | 2004 |
| Dual roles of poly (dA: dT) tracts in replication initiation and fork collapse A Tubbs, S Sridharan, N van Wietmarschen, Y Maman, E Callen, ... Cell 174 (5), 1127-1142. e19, 2018 | 188 | 2018 |
| Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia PD Aplan, DP Lombardi, GH Reaman, HN Sather, GD Hammond, ... | 186 | 1992 |
| An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T‐cell malignancies in transgenic mice PD Aplan, CA Jones, DS Chervinsky, XF Zhao, MK Ellsworth, C Wu, ... The EMBO journal, 1997 | 182 | 1997 |
| Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1 N Pineault, C Buske, M Feuring-Buske, C Abramovich, P Rosten, ... Blood 101 (11), 4529-4538, 2003 | 176 | 2003 |
