| Multitarget drug discovery for Alzheimer's disease: triazinones as BACE‐1 and GSK‐3β inhibitors F Prati, A De Simone, P Bisignano, A Armirotti, M Summa, D Pizzirani, ... Angewandte Chemie 127 (5), 1598-1602, 2015 | 155 | 2015 |
| Versatility of the curcumin scaffold: discovery of potent and balanced dual BACE-1 and GSK-3β inhibitors RMC Di Martino, A De Simone, V Andrisano, P Bisignano, A Bisi, S Gobbi, ... Journal of medicinal chemistry 59 (2), 531-544, 2016 | 125 | 2016 |
| Cilia-associated oxysterols activate smoothened DR Raleigh, N Sever, PK Choksi, MA Sigg, KM Hines, BM Thompson, ... Molecular cell 72 (2), 316-327. e5, 2018 | 122 | 2018 |
| Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions Y Shang, V LeRouzic, S Schneider, P Bisignano, GW Pasternak, ... Biochemistry 53 (31), 5140-5149, 2014 | 106 | 2014 |
| Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site WY Wahlgren, E Dunevall, RA North, A Paz, M Scalise, P Bisignano, ... Nature Communications 9 (1), 1753, 2018 | 87 | 2018 |
| Mitochondrial uncouplers induce proton leak by activating AAC and UCP1 AM Bertholet, AM Natale, P Bisignano, J Suzuki, A Fedorenko, J Hamilton, ... Nature 606 (7912), 180-187, 2022 | 78 | 2022 |
| Inhibitor binding mode and allosteric regulation of Na+-glucose symporters P Bisignano, C Ghezzi, H Jo, NF Polizzi, T Althoff, C Kalyanaraman, ... Nature communications 9 (1), 5245, 2018 | 47 | 2018 |
| Stochastic steps in secondary active sugar transport JL Adelman, C Ghezzi, P Bisignano, DDF Loo, S Choe, J Abramson, ... Proceedings of the National Academy of Sciences 113 (27), E3960-E3966, 2016 | 46 | 2016 |
| Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1 LA Bergdoll, MT Lerch, JW Patrick, K Belardo, C Altenbach, P Bisignano, ... Proceedings of the National Academy of Sciences 115 (2), E172-E179, 2018 | 44 | 2018 |
| Ligand-based discovery of a new scaffold for allosteric modulation of the μ-opioid receptor P Bisignano, NT Burford, Y Shang, B Marlow, KE Livingston, AM Fenton, ... Journal of chemical information and modeling 55 (9), 1836-1843, 2015 | 42 | 2015 |
| Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake JH Wardman, I Gomes, EN Bobeck, JA Stockert, A Kapoor, P Bisignano, ... Science Signaling 9 (430), ra55-ra55, 2016 | 36 | 2016 |
| A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition S Redenti, I Marcovich, T De Vita, C Pérez, R De Zorzi, N Demitri, ... ChemMedChem 14 (3), 310-314, 2019 | 35 | 2019 |
| Conformational transitions of the sodium-dependent sugar transporter, vSGLT A Paz, DP Claxton, JP Kumar, K Kazmier, P Bisignano, S Sharma, ... Proceedings of the National Academy of Sciences 115 (12), E2742-E2751, 2018 | 34 | 2018 |
| Kinetic characterization of fragment binding in AmpC β-lactamase by high-throughput molecular simulations P Bisignano, S Doerr, MJ Harvey, AD Favia, A Cavalli, G De Fabritiis Journal of Chemical Information and Modeling 54 (2), 362-366, 2014 | 26 | 2014 |
| SERAPhiC: a benchmark for in silico fragment-based drug design AD Favia, G Bottegoni, I Nobeli, P Bisignano, A Cavalli Journal of chemical information and modeling 51 (11), 2882-2896, 2011 | 26 | 2011 |
| Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR–nucleotide binding domain 1 P Bisignano, O Moran Biochimie 92 (1), 51-57, 2010 | 26 | 2010 |
| Development and application of a virtual screening protocol for the identification of multitarget fragments G Bottegoni, M Veronesi, P Bisignano, P Kacker, AD Favia, A Cavalli ChemMedChem 11 (12), 1259-1263, 2016 | 24 | 2016 |
| PLI: a web-based tool for the comparison of protein-ligand interactions observed on PDB structures AM Gallina, P Bisignano, M Bergamino, D Bordo Bioinformatics 29 (3), 395-397, 2013 | 20 | 2013 |
| A kinetic mechanism for enhanced selectivity of membrane transport P Bisignano, MA Lee, A George, DM Zuckerman, M Grabe, JM Rosenberg PLoS computational biology 16 (7), e1007789, 2020 | 19 | 2020 |
| Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice B Tolani, A Celli, Y Yao, YZ Tan, R Fetter, CR Liem, AJ de Smith, ... Nature biotechnology 40 (12), 1834-1844, 2022 | 18 | 2022 |
Michael GrabeProfessor, CVRI, Pharmaceutical Chemistry, UCSFEmail verificata su ucsf.edu