| Palaeotemperature trend for Precambrian life inferred from resurrected proteins EA Gaucher, S Govindarajan, OK Ganesh Nature 451 (7179), 704-707, 2008 | 460 | 2008 |
| Resurrecting ancestral alcohol dehydrogenases from yeast JM Thomson, EA Gaucher, MF Burgan, DW De Kee, T Li, JP Aris, ... Nature genetics 37 (6), 630-635, 2005 | 413 | 2005 |
| Evolutionary history and metabolic insights of ancient mammalian uricases JT Kratzer, MA Lanaspa, MN Murphy, C Cicerchi, CL Graves, PA Tipton, ... Proceedings of the National Academy of Sciences 111 (10), 3763-3768, 2014 | 389 | 2014 |
| Inferring the palaeoenvironment of ancient bacteria on the basis of resurrected proteins EA Gaucher, JM Thomson, MF Burgan, SA Benner Nature 425 (6955), 285-288, 2003 | 326 | 2003 |
| Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian β-lactamases VA Risso, JA Gavira, DF Mejia-Carmona, EA Gaucher, JM Sanchez-Ruiz Journal of the American Chemical Society 135 (8), 2899-2902, 2013 | 300 | 2013 |
| Single-molecule paleoenzymology probes the chemistry of resurrected enzymes R Perez-Jimenez, A Inglés-Prieto, ZM Zhao, I Sanchez-Romero, ... Nature structural & molecular biology 18 (5), 592-596, 2011 | 242 | 2011 |
| Uric acid-dependent inhibition of AMP kinase induces hepatic glucose production in diabetes and starvation: evolutionary implications of the uricase loss in hominids C Cicerchi, N Li, J Kratzer, G Garcia, CA Roncal-Jimenez, K Tanabe, ... The FASEB Journal 28 (8), 3339, 2014 | 211 | 2014 |
| Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations RJ Johnson, MA Lanaspa, EA Gaucher Seminars in nephrology 31 (5), 394-399, 2011 | 173 | 2011 |
| Predicting functional divergence in protein evolution by site-specific rate shifts EA Gaucher, X Gu, MM Miyamoto, SA Benner Trends in biochemical sciences 27 (6), 315-321, 2002 | 173 | 2002 |
| Conservation of protein structure over four billion years A Ingles-Prieto, B Ibarra-Molero, A Delgado-Delgado, R Perez-Jimenez, ... Structure 21 (9), 1690-1697, 2013 | 158 | 2013 |
| Planetary biology--paleontological, geological, and molecular histories of life SA Benner, MD Caraco, JM Thomson, EA Gaucher Science 296 (5569), 864-868, 2002 | 147 | 2002 |
| Hydrophobic environment is a key factor for the stability of thermophilic proteins MM Gromiha, MC Pathak, K Saraboji, EA Ortlund, EA Gaucher Proteins: Structure, Function, and Bioinformatics 81 (4), 715-721, 2013 | 144 | 2013 |
| SIRE-1, a copia/Ty1-like retroelement from soybean, encodes a retroviral envelope-like protein HM Laten, A Majumdar, EA Gaucher Proceedings of the National Academy of Sciences 95 (12), 6897-6902, 1998 | 140 | 1998 |
| The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes SE Phillips, P Vincent, KE Rizzieri, G Schaaf, VA Bankaitis, EA Gaucher Critical reviews in biochemistry and molecular biology 41 (1), 21-49, 2006 | 130 | 2006 |
| Function–structure analysis of proteins using covarion-based evolutionary approaches: elongation factors EA Gaucher, MM Miyamoto, SA Benner Proceedings of the National Academy of Sciences 98 (2), 548-552, 2001 | 129 | 2001 |
| Secondary structure and domain architecture of the 23S and 5S rRNAs AS Petrov, CR Bernier, E Hershkovits, Y Xue, CC Waterbury, C Hsiao, ... Nucleic acids research 41 (15), 7522-7535, 2013 | 123 | 2013 |
| Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction PM Zakas, HC Brown, K Knight, SL Meeks, HT Spencer, EA Gaucher, ... Nature biotechnology 35 (1), 35-37, 2017 | 122 | 2017 |
| Reconstructed evolutionary adaptive paths give polymerases accepting reversible terminators for sequencing and SNP detection F Chen, EA Gaucher, NA Leal, D Hutter, SA Havemann, S Govindarajan, ... Proceedings of the National Academy of Sciences 107 (5), 1948-1953, 2010 | 121 | 2010 |
| Diversity of chemical mechanisms in thioredoxin catalysis revealed by single-molecule force spectroscopy R Perez-Jimenez, J Li, P Kosuri, I Sanchez-Romero, AP Wiita, ... Nature structural & molecular biology 16 (8), 890-896, 2009 | 119 | 2009 |
| The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease RJ Johnson, EA Gaucher, YY Sautin, GN Henderson, AJ Angerhofer, ... Medical hypotheses 71 (1), 22-31, 2008 | 116 | 2008 |
