Guidelines for the use and interpretation of assays for monitoring autophagy DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, ... Autophagy 8 (4), 445-544, 2012 | 13612* | 2012 |
The role of autophagy in neurodegenerative disease RA Nixon Nature medicine 19 (8), 983-997, 2013 | 2197 | 2013 |
Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease C Janus, J Pearson, JA McLaurin, PM Mathews, Y Jiang, SD Schmidt, ... Nature 408 (6815), 979-982, 2000 | 2042 | 2000 |
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study RA Nixon, J Wegiel, A Kumar, WH Yu, C Peterhoff, A Cataldo, AM Cuervo Journal of Neuropathology & Experimental Neurology 64 (2), 113-122, 2005 | 1775 | 2005 |
Alzheimer disease DS Knopman, H Amieva, RC Petersen, G Chételat, DM Holtzman, ... Nature reviews Disease primers 7 (1), 33, 2021 | 1620 | 2021 |
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations JH Lee, WH Yu, A Kumar, S Lee, PS Mohan, CM Peterhoff, DM Wolfe, ... Cell 141 (7), 1146-1158, 2010 | 1292 | 2010 |
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease B Boland, A Kumar, S Lee, FM Platt, J Wegiel, WH Yu, RA Nixon Journal of Neuroscience 28 (27), 6926-6937, 2008 | 1261 | 2008 |
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease WH Yu, AM Cuervo, A Kumar, CM Peterhoff, SD Schmidt, JH Lee, ... The Journal of cell biology 171 (1), 87-98, 2005 | 1184 | 2005 |
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations AM Cataldo, CM Peterhoff, JC Troncoso, T Gomez-Isla, BT Hyman, ... The American journal of pathology 157 (1), 277-286, 2000 | 958 | 2000 |
Autophagy, amyloidogenesis and Alzheimer disease RA Nixon Journal of cell science 120 (23), 4081-4091, 2007 | 906 | 2007 |
Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration. K Saito, JS Elce, JE Hamos, RA Nixon Proceedings of the National Academy of Sciences 90 (7), 2628-2632, 1993 | 731 | 1993 |
Autophagy failure in Alzheimer's disease—locating the primary defect RA Nixon, DS Yang Neurobiology of disease 43 (1), 38-45, 2011 | 707 | 2011 |
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration A Salehi, JD Delcroix, PV Belichenko, K Zhan, C Wu, JS Valletta, ... Neuron 51 (1), 29-42, 2006 | 619 | 2006 |
Neurofilaments and neurofilament proteins in health and disease A Yuan, MV Rao, RA Nixon Cold Spring Harbor perspectives in biology 9 (4), a018309, 2017 | 606 | 2017 |
Cdk5 is a key factor in tau aggregation and tangle formation in vivo DK Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K ... Neuron 38 (4), 555-65, 2003 | 589* | 2003 |
Autophagy and its possible roles in nervous system diseases, damage and repair DC Rubinsztein, M DiFiglia, N Heintz, RA Nixon, ZH Qin, B Ravikumar, ... Autophagy 1 (1), 11-22, 2005 | 555 | 2005 |
Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. AM Cataldo, RA Nixon Proceedings of the National Academy of Sciences 87 (10), 3861-3865, 1990 | 551 | 1990 |
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy S Lee, Y Sato, RA Nixon Journal of Neuroscience 31 (21), 7817-7830, 2011 | 530 | 2011 |
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: neuropathologic evidence for a mechanism of increased β-amyloidogenesis AM Cataldo, JL Barnett, C Pieroni, RA Nixon Journal of Neuroscience 17 (16), 6142-6151, 1997 | 526 | 1997 |
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits DS Yang, P Stavrides, PS Mohan, S Kaushik, A Kumar, M Ohno, ... Brain 134 (1), 258-277, 2011 | 504 | 2011 |