| An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi, Y Katoh, T Oyake, ... Biochemical and biophysical research communications 236 (2), 313-322, 1997 | 4528 | 1997 |
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain K Itoh, N Wakabayashi, Y Katoh, T Ishii, K Igarashi, JD Engel, ... Genes & development 13 (1), 76-86, 1999 | 4113 | 1999 |
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 A Kobayashi, MI Kang, H Okawa, M Ohtsuji, Y Zenke, T Chiba, K Igarashi, ... Molecular and cellular biology 24 (16), 7130-7139, 2004 | 2509 | 2004 |
| The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ... Nature cell biology 12 (3), 213-223, 2010 | 2464 | 2010 |
| Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice M Komatsu, S Waguri, M Koike, Y Sou, T Ueno, T Hara, N Mizushima, ... Cell 131 (6), 1149-1163, 2007 | 2422 | 2007 |
| Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants AT Dinkova-Kostova, WD Holtzclaw, RN Cole, K Itoh, N Wakabayashi, ... Proceedings of the National Academy of Sciences 99 (18), 11908-11913, 2002 | 2310 | 2002 |
| Nrf2–Keap1 defines a physiologically important stress response mechanism H Motohashi, M Yamamoto Trends in molecular medicine 10 (11), 549-557, 2004 | 1986 | 2004 |
| Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution K Taguchi, H Motohashi, M Yamamoto Genes to cells 16 (2), 123-140, 2011 | 1744 | 2011 |
| Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages T Ishii, K Itoh, S Takahashi, H Sato, T Yanagawa, Y Katoh, S Bannai, ... Journal of Biological Chemistry 275 (21), 16023-16029, 2000 | 1714 | 2000 |
| Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription EH Kobayashi, T Suzuki, R Funayama, T Nagashima, M Hayashi, ... Nature communications 7 (1), 1-14, 2016 | 1573 | 2016 |
| Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray RK Thimmulappa, KH Mai, S Srisuma, TW Kensler, M Yamamoto, ... Cancer research 62 (18), 5196-5203, 2002 | 1541 | 2002 |
| The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis M Yamamoto, TW Kensler, H Motohashi Physiological reviews 98 (3), 1169-1203, 2018 | 1433 | 2018 |
| Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming Y Mitsuishi, K Taguchi, Y Kawatani, T Shibata, T Nukiwa, H Aburatani, ... Cancer cell 22 (1), 66-79, 2012 | 1423 | 2012 |
| Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice M Ramos-Gomez, MK Kwak, PM Dolan, K Itoh, M Yamamoto, P Talalay, ... Proceedings of the National Academy of Sciences 98 (6), 3410-3415, 2001 | 1393 | 2001 |
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression M McMahon, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 278 (24), 21592-21600, 2003 | 1303 | 2003 |
| Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation M Kobayashi, M Yamamoto Antioxidants & redox signaling 7 (3-4), 385-394, 2005 | 1233 | 2005 |
| Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis RK Thimmulappa, H Lee, T Rangasamy, SP Reddy, M Yamamoto, ... The Journal of clinical investigation 116 (4), 984-995, 2016 | 1187 | 2016 |
| Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ... Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004 | 1170 | 2004 |
| Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice T Rangasamy, CY Cho, RK Thimmulappa, L Zhen, SS Srisuma, ... The Journal of clinical investigation 114 (9), 1248-1259, 2004 | 1169 | 2004 |
| A cross-population atlas of genetic associations for 220 human phenotypes S Sakaue, M Kanai, Y Tanigawa, J Karjalainen, M Kurki, S Koshiba, ... Nature genetics 53 (10), 1415-1424, 2021 | 1167 | 2021 |
Motohashi HozumiInstitute of Development, Aging and Cancer, Tohoku UniversityEmail verificata su tohoku.ac.jp