| Molecular mechanisms of protein aggregation from global fitting of kinetic models G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ... Nature protocols 11 (2), 252-272, 2016 | 714 | 2016 |
| Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ... Nature chemical biology 11 (3), 229-234, 2015 | 694 | 2015 |
| Secondary nucleation in amyloid formation M Törnquist, TCT Michaels, K Sanagavarapu, X Yang, G Meisl, ... Chemical communications 54 (63), 8667-8684, 2018 | 415 | 2018 |
| Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, ... Nature chemistry 12 (5), 445-451, 2020 | 290 | 2020 |
| Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation P Arosio, TCT Michaels, S Linse, C Månsson, C Emanuelsson, J Presto, ... Nature communications 7 (1), 10948, 2016 | 252 | 2016 |
| Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, ... Nature chemistry 10 (6), 673-683, 2018 | 228 | 2018 |
| Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation TCT Michaels, A Šarić, J Habchi, S Chia, G Meisl, M Vendruscolo, ... Annual review of physical chemistry 69 (1), 273-298, 2018 | 209 | 2018 |
| Kinetic diversity of amyloid oligomers AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, ... Proceedings of the National Academy of Sciences 117 (22), 12087-12094, 2020 | 160 | 2020 |
| Fabrication of fibrillosomes from droplets stabilized by protein nanofibrils at all-aqueous interfaces Y Song, U Shimanovich, TCT Michaels, Q Ma, J Li, TPJ Knowles, ... Nature Communications 7 (1), 12934, 2016 | 157 | 2016 |
| Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide SIA Cohen, R Cukalevski, TCT Michaels, A Šarić, M Törnquist, ... Nature chemistry 10 (5), 523-531, 2018 | 149 | 2018 |
| Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ... Nature communications 10 (1), 225, 2019 | 146 | 2019 |
| Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ... Science advances 6 (45), eabb5924, 2020 | 127 | 2020 |
| Dynamic microfluidic control of supramolecular peptide self-assembly ZA Arnon, A Vitalis, A Levin, TCT Michaels, A Caflisch, TPJ Knowles, ... Nature communications 7 (1), 13190, 2016 | 105 | 2016 |
| Physical determinants of the self-replication of protein fibrils A Šarić, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, ... Nature physics 12 (9), 874-880, 2016 | 105 | 2016 |
| Controlling the physical dimensions of peptide nanotubes by supramolecular polymer coassembly L Adler-Abramovich, P Marco, ZA Arnon, RCG Creasey, TCT Michaels, ... ACS nano 10 (8), 7436-7442, 2016 | 105 | 2016 |
| β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, ... Scientific reports 6 (1), 36010, 2016 | 99 | 2016 |
| Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils Y Song, TCT Michaels, Q Ma, Z Liu, H Yuan, S Takayama, TPJ Knowles, ... Nature communications 9 (1), 2110, 2018 | 96 | 2018 |
| Identification of on-and off-pathway oligomers in amyloid fibril formation AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, ... Chemical science 11 (24), 6236-6247, 2020 | 95 | 2020 |
| Measurement of tau filament fragmentation provides insights into prion-like spreading F Kundel, L Hong, B Falcon, WA McEwan, TCT Michaels, G Meisl, ... ACS chemical neuroscience 9 (6), 1276-1282, 2018 | 86 | 2018 |
| Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation A Šarić, TCT Michaels, A Zaccone, TPJ Knowles, D Frenkel The Journal of chemical physics 145 (21), 2016 | 81 | 2016 |
Tuomas KnowlesProfessor of Physical Chemistry and Biophysics, University of CambridgeEmail verificata su cam.ac.uk