| Mammalian caspases: structure, activation, substrates, and functions during apoptosis WC Earnshaw, LM Martins, SH Kaufmann Annual review of biochemistry 68 (1), 383-424, 1999 | 4112 | 1999 |
| Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE YA Lazebnik, SH Kaufmann, S Desnoyers, GG Poirier, WC Earnshaw Nature 371 (6495), 346-347, 1994 | 3340 | 1994 |
| Specific proteolytic cleavage of poly (ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis SH Kaufmann, S Desnoyers, Y Ottaviano, NE Davidson, GG Poirier Cancer research 53 (17), 3976-3985, 1993 | 2602 | 1993 |
| Induction of apoptosis by cancer chemotherapy SH Kaufmann, WC Earnshaw Experimental cell research 256 (1), 42-49, 2000 | 1767 | 2000 |
| PARP inhibition: PARP1 and beyond M Rouleau, A Patel, MJ Hendzel, SH Kaufmann, GG Poirier Nature reviews cancer 10 (4), 293-301, 2010 | 1599 | 2010 |
| Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note SH Kaufmann Cancer research 49 (21), 5870-5878, 1989 | 1338 | 1989 |
| Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial EM Swisher, KK Lin, AM Oza, CL Scott, H Giordano, J Sun, GE Konecny, ... The lancet oncology 18 (1), 75-87, 2017 | 1209 | 2017 |
| Programmed cell death: alive and well in the new millennium SH Kaufmann, MO Hengartner Trends in cell biology 11 (12), 526-534, 2001 | 940 | 2001 |
| Cathepsin B contributes to TNF-α–mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c ME Guicciardi, J Deussing, H Miyoshi, SF Bronk, PA Svingen, C Peters, ... The Journal of clinical investigation 106 (9), 1127-1137, 2000 | 908 | 2000 |
| Caspases and caspase inhibitors P Villa, SH Kaufmann, WC Earnshaw Trends in biochemical sciences 22 (10), 388-393, 1997 | 809 | 1997 |
| The current status of camptothecin analogues as antitumor agents WJ Slichenmyer, EK Rowinsky, RC Donehower, SH Kaufmann JNCI: Journal of the National Cancer Institute 85 (4), 271-291, 1993 | 801 | 1993 |
| The role of proteases during apoptosis T Patel, GJ Gores, SH Kaufmann The FASEB Journal 10 (5), 587-597, 1996 | 714 | 1996 |
| Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in … A Takahashi, ES Alnemri, YA Lazebnik, T Fernandes-Alnemri, G Litwack, ... Proceedings of the National Academy of Sciences 93 (16), 8395-8400, 1996 | 709 | 1996 |
| Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. YA Lazebnik, A Takahashi, RD Moir, RD Goldman, GG Poirier, ... Proceedings of the National Academy of Sciences 92 (20), 9042-9046, 1995 | 699 | 1995 |
| Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas WA Faubion, ME Guicciardi, H Miyoshi, SF Bronk, PJ Roberts, ... The Journal of clinical investigation 103 (1), 137-145, 1999 | 682 | 1999 |
| Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma TE Witzig, SM Geyer, I Ghobrial, DJ Inwards, R Fonseca, P Kurtin, ... Journal of Clinical Oncology 23 (23), 5347-5356, 2005 | 632 | 2005 |
| Nonhomologous end joining drives poly (ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells AG Patel, JN Sarkaria, SH Kaufmann Proceedings of the National Academy of Sciences 108 (8), 3406-3411, 2011 | 611 | 2011 |
| Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial JE Karp, JE Lancet, SH Kaufmann, DW End, JJ Wright, K Bol, I Horak, ... Blood, The Journal of the American Society of Hematology 97 (11), 3361-3369, 2001 | 602 | 2001 |
| Phase I and pharmacologic study of topotecan: a novel topoisomerase I inhibitor. EK Rowinsky, LB Grochow, CB Hendricks, DS Ettinger, AA Forastiere, ... Journal of clinical oncology 10 (4), 647-656, 1992 | 466 | 1992 |
| Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse SH Kaufmann, JE Karp, PA Svingen, S Krajewski, PJ Burke, SD Gore, ... Blood, The Journal of the American Society of Hematology 91 (3), 991-1000, 1998 | 455 | 1998 |
W.C. EarnshawUniversity of EdinburghEmail verificata su ed.ac.uk
