Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia CM Metallo, PA Gameiro, EL Bell, KR Mattaini, J Yang, K Hiller, ... Nature 481 (7381), 380-384, 2012 | 1987 | 2012 |
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis JW Locasale, AR Grassian, T Melman, CA Lyssiotis, KR Mattaini, AJ Bass, ... Nature genetics 43 (9), 869-874, 2011 | 1207 | 2011 |
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis D Anastasiou, Y Yu, WJ Israelsen, JK Jiang, MB Boxer, BS Hong, ... Nature chemical biology 8 (10), 839-847, 2012 | 809 | 2012 |
The importance of serine metabolism in cancer KR Mattaini, MR Sullivan, MG Vander Heiden Journal of Cell Biology 214 (3), 249-257, 2016 | 410 | 2016 |
Metabolic pathway alterations that support cell proliferation MG Vander Heiden, SY Lunt, TL Dayton, BP Fiske, WJ Israelsen, ... Cold Spring Harbor symposia on quantitative biology 76, 325-334, 2011 | 343 | 2011 |
Increased serine synthesis provides an advantage for tumors arising in tissues where serine levels are limiting MR Sullivan, KR Mattaini, EA Dennstedt, AA Nguyen, S Sivanand, ... Cell metabolism 29 (6), 1410-1421. e4, 2019 | 221 | 2019 |
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate J Fan, X Teng, L Liu, KR Mattaini, RE Looper, MG Vander Heiden, ... ACS chemical biology 10 (2), 510-516, 2015 | 199 | 2015 |
PHGDH amplification and altered glucose metabolism in human melanoma E Mullarky, KR Mattaini, MG Vander Heiden, LC Cantley, JW Locasale Pigment cell & melanoma research 24 (6), 1112-1115, 2011 | 164 | 2011 |
BRD4 short isoform interacts with RRP1B, SIPA1 and components of the LINC complex at the inner face of the nuclear membrane J Alsarraj, F Faraji, TR Geiger, KR Mattaini, M Williams, J Wu, NH Ha, ... PloS one 8 (11), e80746, 2013 | 64 | 2013 |
The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor NPS Crawford, H Yang, KR Mattaini, KW Hunter Journal of Biological Chemistry 284 (42), 28660-28673, 2009 | 45 | 2009 |
An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation KR Mattaini, EJ Brignole, M Kini, SM Davidson, BP Fiske, CL Drennan, ... Cancer & metabolism 3, 1-12, 2015 | 38 | 2015 |
Glycosylation to adapt to stress KR Mattaini, MG Vander Heiden Science 337 (6097), 925-926, 2012 | 21 | 2012 |
Increased PHGDH expression promotes aberrant melanin accumulation KR Mattaini, MR Sullivan, AN Lau, BP Fiske, RT Bronson, ... BMC cancer 19, 1-11, 2019 | 12 | 2019 |
Increased PHGDH expression uncouples hair follicle cycle progression and promotes inappropriate melanin accumulation KR Mattaini, MR Sullivan, AN Lau, BP Fiske, RT Bronson, ... bioRxiv, 249250, 2018 | 1 | 2018 |
Abstract PR10: Serine biosynthesis from glucose regulates folate availability CA Lewis, BP Fiske, ME Pacold, AM Hosios, KR Mattaini, DM Sabatini, ... Molecular Cancer Research 14 (1_Supplement), PR10-PR10, 2016 | | 2016 |
The role of phosphoglycerate dehydrogenase in cell proliferation and tumor progression KR Mattaini Massachusetts Institute of Technology, 2015 | | 2015 |
The metastasis efficiency modifier ribosomal RNA processing 1 homologue (RRP1B) is a chromatin-associated factor NPS Crawford, H Yang, KR Mattaini, KW Hunter Cancer Research 70 (8_Supplement), 2372-2372, 2010 | | 2010 |