| Structural identification of the pathway of long-range communication in an allosteric enzyme PS Gandhi, Z Chen, FS Mathews, E Di Cera Proceedings of the National Academy of Sciences 105 (6), 1832-1837, 2008 | 133 | 2008 |
| Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1 PS Gandhi, Z Chen, E Di Cera Journal of Biological Chemistry 285 (20), 15393-15398, 2010 | 79 | 2010 |
| A factor VIIIa–mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice H Østergaard, J Lund, PJ Greisen, S Kjellev, A Henriksen, N Lorenzen, ... Blood, The Journal of the American Society of Hematology 138 (14), 1258-1268, 2021 | 56 | 2021 |
| Engineering thrombin for selective specificity toward protein C and PAR1 F Marino, LA Pelc, A Vogt, PS Gandhi, E Di Cera Journal of Biological Chemistry 285 (25), 19145-19152, 2010 | 56 | 2010 |
| Crystallographic and kinetic evidence of allostery in a trypsin-like protease W Niu, Z Chen, PS Gandhi, AD Vogt, N Pozzi, LA Pelc, F Zapata, ... Biochemistry 50 (29), 6301-6307, 2011 | 50 | 2011 |
| Mutant N143P reveals how Na+ activates thrombin W Niu, Z Chen, LA Bush-Pelc, A Bah, PS Gandhi, E Di Cera Journal of Biological Chemistry 284 (52), 36175-36185, 2009 | 42 | 2009 |
| Structural basis of thrombin–protease‐activated receptor interactions PS Gandhi, Z Chen, E Appelbaum, F Zapata, E Di Cera IUBMB life 63 (6), 375-382, 2011 | 33 | 2011 |
| Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A PS Gandhi, MJ Page, Z Chen, L Bush-Pelc, E Di Cera Journal of Biological Chemistry 284 (36), 24098-24105, 2009 | 33 | 2009 |
| Na+ binding to meizothrombin desF1 ME Papaconstantinou, PS Gandhi, Z Chen, A Bah, E Di Cera Cellular and molecular life sciences 65, 3688-3697, 2008 | 33 | 2008 |
| Stabilization of the E* form turns thrombin into an anticoagulant A Bah, CJ Carrell, Z Chen, PS Gandhi, E Di Cera Journal of Biological Chemistry 284 (30), 20034-20040, 2009 | 30 | 2009 |
| Structural insight into antibody-mediated antagonism of the glucagon-like peptide-1 receptor S Hennen, JT Kodra, V Soroka, BO Krogh, X Wu, P Kaastrup, C Ørskov, ... Scientific Reports 6 (1), 26236, 2016 | 27 | 2016 |
| Molecular basis of enhanced activity in factor VIIa-trypsin variants conveys insights into tissue factor-mediated allosteric regulation of factor VIIa activity AB Sorensen, JJ Madsen, LA Svensson, AA Pedersen, H Østergaard, ... Journal of Biological Chemistry 291 (9), 4671-4683, 2016 | 23 | 2016 |
| Mim8-A next-generation FVIII mimetic bi-specific antibody-potently restores the hemostatic capacity in hemophilia a settings in vitro and in vivo SL Kjellev, H Østergaard, MB Hermit, K Thorn, BG Hansen, R Zhou, ... Blood 134, 96, 2019 | 21 | 2019 |
| 19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2 EA Ruben, PS Gandhi, Z Chen, SK Koester, GT DeKoster, C Frieden, ... Journal of Biological Chemistry 295 (24), 8227-8235, 2020 | 15 | 2020 |
| Allostery in coagulation factor VIIa revealed by ensemble refinement of crystallographic structures AB Sorensen, JJ Madsen, TM Frimurer, MT Overgaard, PS Gandhi, ... Biophysical Journal 116 (10), 1823-1835, 2019 | 10 | 2019 |
| Beating tissue factor at its own game: Design and properties of a soluble tissue factor–independent coagulation factor VIIa AB Sorensen, I Tuneew, LA Svensson, E Persson, H Østergaard, ... Journal of Biological Chemistry 295 (2), 517-528, 2020 | 9 | 2020 |
| Engineering of a membrane-triggered activity switch in coagulation factor VIIa AL Nielsen, AB Sorensen, HL Holmberg, PS Gandhi, J Karlsson, ... Proceedings of the National Academy of Sciences 114 (47), 12454-12459, 2017 | 7 | 2017 |
| Coagulation factor VII polypeptides H Oestergaard, PS Gandhi, OH Olsen US Patent 9,371,370, 2016 | 5 | 2016 |
| A bispecific antibody approach for the potential prophylactic treatment of inherited bleeding disorders PS Gandhi, M Zivkovic, H Østergaard, AC Bonde, T Elm, MN Løvgreen, ... Nature Cardiovascular Research 3 (2), 166-185, 2024 | 4 | 2024 |
| HMB-001-A NOVEL BISPECIFIC ANTIBODY WITH POTENTIAL FOR SUBCUTANEOUS PROPHYLACTIC TREATMENT OF MULTIPLE BLEEDING DISORDERS-INITIAL FOCUS ON GLANZMANN THROMBASTHENIA (GT) PS Gandhi, M Zivkovic, H Ostergaard, F Rode, DM Karpf, ... Haemophilia 28, 18-19, 2022 | 4 | 2022 |
Anders Bundgård SørensenNykode Therapeutics, Principal Scientist, Oncology Discovery LeadEmail verificata su askyvc.dk