| Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex DD Sarbassov, DA Guertin, SM Ali, DM Sabatini Science 307 (5712), 1098-1101, 2005 | 8483 | 2005 |
| mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery DH Kim, DD Sarbassov, SM Ali, JE King, RR Latek, ... Cell 110 (2), 163-175, 2002 | 3781 | 2002 |
| Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton DD Sarbassov, SM Ali, DH Kim, DA Guertin, RR Latek, ... Current biology 14 (14), 1296-1302, 2004 | 3474 | 2004 |
| Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB DD Sarbassov, SM Ali, S Sengupta, JH Sheen, PP Hsu, AF Bagley, ... Molecular cell 22 (2), 159-168, 2006 | 3333 | 2006 |
| Growing roles for the mTOR pathway DD Sarbassov, SM Ali, DM Sabatini Current opinion in cell biology 17 (6), 596-603, 2005 | 2030 | 2005 |
| GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR DH Kim, DD Sarbassov, SM Ali, RR Latek, KVP Guntur, ... Molecular cell 11 (4), 895-904, 2003 | 1293 | 2003 |
| The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis CH Chan, CF Li, WL Yang, Y Gao, SW Lee, Z Feng, HY Huang, KKC Tsai, ... Cell 149 (5), 1098-1111, 2012 | 439 | 2012 |
| Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML Z Zeng, DD Sarbassov, IJ Samudio, KWL Yee, MF Munsell, ... Blood 109 (8), 3509-3512, 2007 | 406 | 2007 |
| Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex DD Sarbassov, DM Sabatini Journal of Biological Chemistry 280 (47), 39505-39509, 2005 | 279 | 2005 |
| FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse KE Hentges, B Sirry, AC Gingeras, D Sarbassov, N Sonenberg, ... Proceedings of the National Academy of Sciences 98 (24), 13796-13801, 2001 | 230 | 2001 |
| ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies JO Ishizawa, K Kojima, D Chachad, P Ruvolo, V Ruvolo, RO Jacamo, ... Science signaling 9 (415), ra17-ra17, 2016 | 189 | 2016 |
| ER stress inhibits mTORC2 and Akt signaling through GSK-3β–mediated phosphorylation of Rictor CH Chen, T Shaikenov, TR Peterson, R Aimbetov, AK Bissenbaev, ... Science signaling 4 (161), ra10-ra10, 2011 | 176 | 2011 |
| FoxO transcription factors promote AKT Ser473 phosphorylation and renal tumor growth in response to pharmacologic inhibition of the PI3K–AKT pathway A Lin, H Piao, L Zhuang, DD Sarbassov, L Ma, B Gan Cancer research 74 (6), 1682-1693, 2014 | 141 | 2014 |
| Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers R Zhao, SCJ Yeung, J Chen, T Iwakuma, CH Su, B Chen, C Qu, F Zhang, ... The Journal of clinical investigation 121 (3), 851-865, 2011 | 131 | 2011 |
| A hypoxia-responsive TRAF6–ATM–H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis AH Rezaeian, CF Li, CY Wu, X Zhang, J Delacerda, MJ You, F Han, Z Cai, ... Nature cell biology 19 (1), 38-51, 2017 | 109 | 2017 |
| Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers M Morrison Joly, DJ Hicks, B Jones, V Sanchez, MV Estrada, C Young, ... Cancer research 76 (16), 4752-4764, 2016 | 108 | 2016 |
| Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation Y Liao, Y Wei, X Zhou, JY Yang, C Dai, YJ Chen, NK Agarwal, ... Oncogene 28 (26), 2436-2445, 2009 | 104 | 2009 |
| Rictor phosphorylation on the Thr-1135 site does not require mammalian target of rapamycin complex 2 D Boulbes, CH Chen, T Shaikenov, NK Agarwal, TR Peterson, TA Addona, ... Molecular Cancer Research 8 (6), 896-906, 2010 | 94 | 2010 |
| Extracellular signal-regulated kinase-1 and-2 respond differently to mitogenic and differentiative signaling pathways in myoblasts DD Sarbassov, LG Jones, CA Peterson Molecular Endocrinology 11 (13), 2038-2047, 1997 | 94 | 1997 |
| Endoplasmic reticulum is a main localization site of mTORC2 DR Boulbés, T Shaiken, DD Sarbassov Biochemical and biophysical research communications 413 (1), 46-52, 2011 | 93 | 2011 |