| Delineating the role of cooperativity in the design of potent PROTACs for BTK A Zorba, C Nguyen, Y Xu, J Starr, K Borzilleri, J Smith, H Zhu, KA Farley, ... Proceedings of the National Academy of Sciences 115 (31), E7285-E7292, 2018 | 363 | 2018 |
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination MVS Varma, RS Obach, C Rotter, HR Miller, G Chang, SJ Steyn, ... Journal of medicinal chemistry 53 (3), 1098-1108, 2010 | 315 | 2010 |
| Development of a new permeability assay using low‐efflux MDCKII cells L Di, C Whitney‐Pickett, JP Umland, H Zhang, X Zhang, DF Gebhard, ... Journal of pharmaceutical sciences 100 (11), 4974-4985, 2011 | 290 | 2011 |
| Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS) MV Varma, SJ Steyn, C Allerton, AF El-Kattan Pharmaceutical research 32, 3785-3802, 2015 | 270 | 2015 |
| Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data HM Jones, HA Barton, Y Lai, Y Bi, E Kimoto, S Kempshall, SC Tate, ... Drug Metabolism and Disposition 40 (5), 1007-1017, 2012 | 265 | 2012 |
| Physicochemical determinants of human renal clearance MVS Varma, B Feng, RS Obach, MD Troutman, J Chupka, HR Miller, ... Journal of medicinal chemistry 52 (15), 4844-4852, 2009 | 217 | 2009 |
| The road map to oral bioavailability: an industrial perspective VH Thomas, S Bhattachar, L Hitchingham, P Zocharski, M Naath, ... Expert opinion on drug metabolism & toxicology 2 (4), 591-608, 2006 | 211 | 2006 |
| The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities AF El-Kattan, CS Asbill, N Kim, BB Michniak International Journal of Pharmaceutics 215 (1-2), 229-240, 2001 | 202 | 2001 |
| The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems AF El-Kattan, CS Asbill, BB Michniak International journal of pharmaceutics 198 (2), 179-189, 2000 | 187 | 2000 |
| Enhancement of transdermal drug delivery: chemical and physical approaches CS Asbill, AF El-Kattan, B Michniak Critical Reviews™ in Therapeutic Drug Carrier Systems 17 (6), 2000 | 184 | 2000 |
| How modeling and simulation have enhanced decision making in new drug development R Miller, W Ewy, BW Corrigan, D Ouellet, D Hermann, KG Kowalski, ... Journal of pharmacokinetics and pharmacodynamics 32, 185-197, 2005 | 181 | 2005 |
| pH-Dependent solubility and permeability criteria for provisional biopharmaceutics classification (BCS and BDDCS) in early drug discovery MV Varma, I Gardner, SJ Steyn, P Nkansah, CJ Rotter, C Whitney-Pickett, ... Molecular pharmaceutics 9 (5), 1199-1212, 2012 | 171 | 2012 |
| Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans S Hurst, CM Loi, J Brodfuehrer, A El-Kattan Expert opinion on drug metabolism & toxicology 3 (4), 469-489, 2007 | 158 | 2007 |
| Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent d-Amino Acid Oxidase (DAAO) Inhibitors AJ Duplantier, SL Becker, MJ Bohanon, KA Borzilleri, BA Chrunyk, ... Journal of medicinal chemistry 52 (11), 3576-3585, 2009 | 137 | 2009 |
| Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical … JA Pfefferkorn, A Guzman-Perez, J Litchfield, R Aiello, JL Treadway, ... Journal of medicinal chemistry 55 (3), 1318-1333, 2012 | 133 | 2012 |
| Targeting intestinal transporters for optimizing oral drug absorption M V Varma, C M Ambler, M Ullah, C J Rotter, H Sun, J Litchfield, ... Current drug metabolism 11 (9), 730-742, 2010 | 133 | 2010 |
| pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1 MV Varma, CJ Rotter, J Chupka, KM Whalen, DB Duignan, B Feng, ... Molecular pharmaceutics 8 (4), 1303-1313, 2011 | 117 | 2011 |
| Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes E Kimoto, K Yoshida, LM Balogh, Y Bi, K Maeda, A El-Kattan, Y Sugiyama, ... Molecular pharmaceutics 9 (12), 3535-3542, 2012 | 116 | 2012 |
| Mechanistic modeling to predict the transporter-and enzyme-mediated drug-drug interactions of repaglinide MVS Varma, Y Lai, E Kimoto, TC Goosen, AF El-Kattan, V Kumar Pharmaceutical research 30, 1188-1199, 2013 | 114 | 2013 |
| Evaluation of a human bio-engineered skin equivalent for drug permeation studies C Asbill, N Kim, A El-Kattan, K Creek, P Wertz, B Michniak Pharmaceutical research 17, 1092-1097, 2000 | 112 | 2000 |
Manthena V. VarmaPharmacokinetics, dynamics and metabolismEmail verificata su pfizer.com
