Gene therapy in a patient with sickle cell disease JA Ribeil, S Hacein-Bey-Abina, E Payen, A Magnani, M Semeraro, ... New England Journal of Medicine 376 (9), 848-855, 2017 | 798 | 2017 |
Defining genome architecture at base-pair resolution P Hua, M Badat, LLP Hanssen, LD Hentges, N Crump, DJ Downes, ... Nature 595 (7865), 125-129, 2021 | 142 | 2021 |
Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia S Mettananda, CA Fisher, D Hay, M Badat, L Quek, K Clark, P Hublitz, ... Nature communications 8 (1), 424, 2017 | 109 | 2017 |
Editing an alpha-globin enhancer in primary human hematopoietic stem cells as a treatment for beta-thalassemia. Nat Commun 8 (1): 424 S Mettananda, CA Fisher, D Hay, M Badat, L Quek, K Clark, P Hublitz, ... | 28 | 2017 |
Treatment of diffuse large B‐cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS‐penetrating R‐IDARAM chemotherapy P Maciocia, M Badat, S Cheesman, S D'Sa, R Joshi, J Lambert, ... British journal of haematology 172 (4), 545-553, 2016 | 28 | 2016 |
Direct correction of haemoglobin E β-thalassaemia using base editors M Badat, A Ejaz, P Hua, S Rice, W Zhang, LD Hentges, CA Fisher, ... Nature Communications 14 (1), 2238, 2023 | 17 | 2023 |
Combination-therapy with concurrent deferoxamine and deferiprone is effective in treating resistant cardiac iron-loading in aceruloplasminaemia. M Badat, B Kaya, P Telfer British Journal of Haematology 171 (3), 2015 | 17 | 2015 |
A remarkable case of HbH disease illustrates the relative contributions of the α-globin enhancers to gene expression M Badat, JOJ Davies, CA Fisher, DJ Downes, A Rose, AB Glenthøj, ... Blood, The Journal of the American Society of Hematology 137 (4), 572-575, 2021 | 9 | 2021 |
Vaccine‐induced immune thrombocytopenia and thrombosis: The decline in anti‐platelet factor 4 antibodies is assay‐dependent. S Platton, L Schönborn, S Charrot, M Badat, J Boot, V McDonald, ... British Journal of Haematology 197 (4), 2022 | 8 | 2022 |
Expression of the human alpha-globin cluster in the absence of the major regulatory element MCS-R2 M Badat, JOJ Davies, EJ van Beers, C Harteveld, D Downes, DR Higgs Blood 132, 3632, 2018 | 2 | 2018 |
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita H Tummala, AJ Walne, M Badat, M Patel, AM Walne, J Alnajar, CC Chow, ... EMBO Molecular Medicine, 1-23, 2024 | 1 | 2024 |
Base Editing Repairs the HbE Mutation Restoring the Production of Normal Globin Chains in Severe HbE/β-Thalassemia Patient Hematopoietic Stem Cells and Erythroid Cells M Badat, P Hua, S Mettananda, C Fisher, N Roy, S Rice, A Roy, DR Higgs, ... Blood 138, 2935, 2021 | 1 | 2021 |
Scientific business abstracts of the 113th annual meeting of the Association of Physicians of Great Britain and Ireland TM Cacciottolo, A Perikari, A van der Klaauw, E Henning, LKJ Stadler, ... QJM: An International Journal of Medicine 112 (9), 724-729, 2019 | 1 | 2019 |
Beginnings: the molecular pathology of hemoglobin D Higgs, M Badat Molecular Hematology, 1-16, 2024 | | 2024 |
Ancient genomic linkage couples metabolism with erythroid development AE Preston, JN Frost, M Badat, M Teh, AE Armitage, R Norfo, ... bioRxiv, 2023 | | 2023 |
An Ancient Transcriptional Hub Couples Developmentally Regulated Gene Expression with Metabolism during Erythropoiesis AE Preston, JN Frost, M Badat, AE Armitage, S Wideman, M Teh, R Norfo, ... Blood 140 (Supplement 1), 4-5, 2022 | | 2022 |
Editing of haemoglobin genes J Davies, D Higgs, M Badat US Patent App. 17/278,679, 2022 | | 2022 |
P104: base editing repairs the HbE mutation restoring the production of normal globin chains in severe HbE/β-thalassemia patient hematopoietic stem and erythroid cells M Badat, P Hua, S Mettananda, C Fisher, N Roy, S Rice, A Roy, D Higgs, ... HemaSphere 6, 19-20, 2022 | | 2022 |
Developing genome-editing strategies to ameliorate HbE/beta-thalassaemia M Badat University of Oxford, 2021 | | 2021 |
Genome editing of haemopoietic stem cells for treatment of thalassaemia M Badat, S Mettananda, P Hua, R Schwessinger, J Hughes, D Higgs, ... Oxford University Press, 2019 | | 2019 |