Ikuti
Nicholas G. Paciaroni
Nicholas G. Paciaroni
Medical Science Liaison - The Binding Site, part of Thermo Fisher Scientific
Email yang diverifikasi di thermofisher.com
Judul
Dikutip oleh
Dikutip oleh
Tahun
A tryptoline ring‐distortion strategy leads to complex and diverse biologically active molecules from the indole alkaloid yohimbine
NG Paciaroni, R Ratnayake, JH Matthews, VM Norwood IV, AC Arnold, ...
Chemistry–A European Journal 23 (18), 4327-4335, 2017
792017
Bromophenazine derivatives with potent inhibition, dispersion and eradication activities against Staphylococcus aureus biofilms
AT Garrison, F Bai, Y Abouelhassan, NG Paciaroni, S Jin, RW Huigens III
Rsc Advances 5 (2), 1120-1124, 2015
522015
Beyond protein binding: recent advances in screening DNA-encoded libraries
T Kodadek, NG Paciaroni, M Balzarini, P Dickson
Chemical Communications 55 (89), 13330-13341, 2019
492019
Solid-phase synthesis of DNA-encoded libraries via an “aldehyde explosion” strategy
NG Paciaroni, JM Ndungu, T Kodadek
Chemical Communications 56 (34), 4656-4659, 2020
392020
Synthesis and Screening of a DNA‐Encoded Library of Non‐Peptidic Macrocycles
E Koesema, A Roy, NG Paciaroni, C Coito, M Tokmina‐Roszyk, ...
Angewandte Chemie 134 (18), e202116999, 2022
262022
Re-engineering of yohimbine’s biological activity through ring distortion: identification and structure–activity relationships of a new class of antiplasmodial agents
NG Paciaroni, DL Perry, VM Norwood IV, C Murillo-Solano, J Collins, ...
ACS infectious diseases 6 (2), 159-167, 2020
242020
Yohimbine as a starting point to access diverse natural product-like agents with re-programmed activities against cancer-relevant GPCR targets
NG Paciaroni, VM Norwood IV, R Ratnayake, H Luesch, RW Huigens III
Bioorganic & medicinal chemistry 28 (14), 115546, 2020
222020
VM t. Norwood, AC Arnold, LH Dang, H. Luesch and RW Huigens 3rd
NG Paciaroni, R Ratnayake, JH Matthews
Chem.–Eur. J 23, 4327-4335, 2017
62017
Rapid Synthesis of Phenazine-1-Carboxylic Acid Derived SmallMolecules from Diverse Anilines: Privileged Structures for Discovery
NG Paciaroni, NV Borrero, JR Rocca, RW Huigens III
Res. Rev.: J. Med. Org. Chem 2, 67-76, 2015
62015
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival
MV Guijarro, PC Kellish, PE Dib, NG Paciaroni, A Nawab, J Andring, ...
JCI insight 8 (10), e158798, 2023
32023
Identification and characterization of a nonbiological small-molecular mimic of a Zika virus conformational neutralizing epitope
PMS Castanha, PJ McEnaney, Y Park, A Bouwer, EJF Chaves, RD Lins, ...
Proceedings of the National Academy of Sciences 121 (21), e2312755121, 2024
22024
Microwave-enhanced, stereospecific ring-closure of medium-ring cyanamide ethers to yohimbine
NG Paciaroni, VM Norwood IV, DE Garcia, RW Huigens III
Tetrahedron Letters 60 (17), 1182-1185, 2019
22019
Analogs of yohimbine and uses thereof
RW HUIGENS III, NG PACIARONI
12017
Back Cover: A Tryptoline Ring‐Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine (Chem. Eur. J. 18/2017)
NG Paciaroni, R Ratnayake, JH Matthews, VM Norwood IV, AC Arnold, ...
Chemistry–A European Journal 23 (18), 4463-4463, 2017
12017
First in class multifunctional non classical antifolates inhibits thymidylate synthase and extends survival in pancreatic cancer model
MV Guijarro, PC Kellish, PE Dib, NG Paciaroni, A Nawab, J Andring, ...
Cancer Research 82 (12_Supplement), 4055-4055, 2022
2022
Analogs of yohimbine and uses thereof
RW Huigens III, NG Paciaroni, H Luesch
US Patent 11,242,331, 2022
2022
Ring Distortion of Yohimbine Leads to Diverse Biological Discoveries
NG Paciaroni
University of Florida, 2018
2018
Research & Reviews: Journal of Medicinal & Organic Chemistry
NG Paciaroni, NV Borrero, JR Rocca, RWH III
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