Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery S Lin, BT Staahl, RK Alla, JA Doudna elife 3, e04766, 2014 | 1439 | 2014 |
An essential switch in subunit composition of a chromatin remodeling complex during neural development J Lessard, JI Wu, JA Ranish, M Wan, MM Winslow, BT Staahl, H Wu, ... Neuron 55 (2), 201-215, 2007 | 902 | 2007 |
MicroRNA-mediated switching of chromatin-remodelling complexes in neural development AS Yoo, BT Staahl, L Chen, GR Crabtree Nature 460 (7255), 642-646, 2009 | 734 | 2009 |
An embryonic stem cell chromatin remodeling complex, esBAF, is essential for embryonic stem cell self-renewal and pluripotency L Ho, JL Ronan, J Wu, BT Staahl, L Chen, A Kuo, J Lessard, ... Proceedings of the National Academy of Sciences 106 (13), 5181-5186, 2009 | 680 | 2009 |
CasX enzymes comprise a distinct family of RNA-guided genome editors JJ Liu, N Orlova, BL Oakes, E Ma, HB Spinner, KLM Baney, J Chuck, ... Nature 566 (7743), 218-223, 2019 | 466 | 2019 |
Rational design of a split-Cas9 enzyme complex AV Wright, SH Sternberg, DW Taylor, BT Staahl, JA Bardales, JE Kornfeld, ... Proceedings of the National Academy of Sciences 112 (10), 2984-2989, 2015 | 390 | 2015 |
Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes BT Staahl, M Benekareddy, C Coulon-Bainier, AA Banfal, SN Floor, ... Nature biotechnology 35 (5), 431-434, 2017 | 383 | 2017 |
Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch BL Oakes, DC Nadler, A Flamholz, C Fellmann, BT Staahl, JA Doudna, ... Nature biotechnology 34 (6), 646-651, 2016 | 226 | 2016 |
A thermostable Cas9 with increased lifetime in human plasma LB Harrington, D Paez-Espino, BT Staahl, JS Chen, E Ma, NC Kyrpides, ... Nature communications 8 (1), 1424, 2017 | 214 | 2017 |
Oxygen sensing in yeast: evidence for the involvement of the respiratory chain in regulating the transcription of a subset of hypoxic genes KE Kwast, PV Burke, BT Staahl, RO Poyton Proceedings of the National Academy of Sciences 96 (10), 5446-5451, 1999 | 208 | 1999 |
Exome sequencing to identify de novo mutations in sporadic ALS trios A Chesi, BT Staahl, A Jovičić, J Couthouis, M Fasolino, AR Raphael, ... Nature neuroscience 16 (7), 851-855, 2013 | 173 | 2013 |
Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways BT Staahl, J Tang, W Wu, A Sun, AD Gitler, AS Yoo, GR Crabtree Journal of Neuroscience 33 (25), 10348-10361, 2013 | 143 | 2013 |
Yeast flavohemoglobin, a nitric oxide oxidoreductase, is located in both the cytosol and the mitochondrial matrix: effects of respiration, anoxia, and the mitochondrial genome … N Cassanova, KM O'Brien, BT Stahl, T McClure, RO Poyton Journal of Biological Chemistry 280 (9), 7645-7653, 2005 | 104 | 2005 |
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery T Gaj, BT Staahl, GMC Rodrigues, P Limsirichai, FK Ekman, JA Doudna, ... Nucleic acids research 45 (11), e98-e98, 2017 | 97 | 2017 |
Site-specific bioconjugation through enzyme-catalyzed tyrosine–cysteine bond formation MJ Lobba, C Fellmann, AM Marmelstein, JC Maza, EN Kissman, ... ACS Central Science 6 (9), 1564-1571, 2020 | 74 | 2020 |
Creating a neural specific chromatin landscape by npBAF and nBAF complexes BT Staahl, GR Crabtree Current opinion in neurobiology 23 (6), 903-913, 2013 | 61 | 2013 |
Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism W Wenderski, L Wang, A Krokhotin, JJ Walsh, H Li, H Shoji, S Ghosh, ... Proceedings of the National Academy of Sciences 117 (18), 10055-10066, 2020 | 48 | 2020 |
Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules A Shams, SA Higgins, C Fellmann, TG Laughlin, BL Oakes, R Lew, S Kim, ... Nature communications 12 (1), 5664, 2021 | 46 | 2021 |
Methods and compositions for rna-directed target dna modification JA Doudna, S Lin, BT Staahl | 22 | 2016 |
CRISPR-CasX is an RNA-dominated enzyme active for human genome editing JJ Liu, N Orlova, BL Oakes, E Ma, HB Spinner, KLM Baney, J Chuck, ... Nature 566 (7743), 218, 2019 | 12 | 2019 |