| Discovery of 3-(2, 6-dichloro-3, 5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor … V Guagnano, P Furet, C Spanka, V Bordas, M Le Douget, C Stamm, ... Journal of medicinal chemistry 54 (20), 7066-7083, 2011 | 517 | 2011 |
| The origin of the oxidative burst in plants GP Bolwell, VS Butt, DR Davies, A Zimmerlin Free radical research 23 (6), 517-532, 1995 | 486 | 1995 |
| Plant cytochrome P450 GP Bolwell, K Bozak, A Zimmerlin Phytochemistry 37 (6), 1491-1506, 1994 | 370 | 1994 |
| Discovery of LOU064 (remibrutinib), a potent and highly selective covalent inhibitor of Bruton’s tyrosine kinase D Angst, F Gessier, P Janser, A Vulpetti, R Wälchli, C Beerli, ... Journal of medicinal chemistry 63 (10), 5102-5118, 2020 | 160 | 2020 |
| Tissue and subcellular immunolocalisation of enzymes of lignin synthesis in differentiating and wounded hypocotyl tissue of French bean (Phaseolus vulgaris L.) CG Smith, MW Rodgers, A Zimmerlin, D Ferdinando, GP Bolwell Planta 192, 155-164, 1994 | 129 | 1994 |
| Metabolic soft spot identification and compound optimization in early discovery phases using MetaSite and LC-MS/MS validation M Trunzer, B Faller, A Zimmerlin Journal of medicinal chemistry 52 (2), 329-335, 2009 | 121 | 2009 |
| Molecular identification and expression of the peroxidase responsible for the oxidative burst in French bean (Phaseolus vulgaris L.) and related members of the gene family KA Blee, SC Jupe, G Richard, A Zimmerlin, DR Davies, GP Bolwell Plant Molecular Biology 47, 607-620, 2001 | 121 | 2001 |
| Aryl hydroxylation of the herbicide diclofop by a wheat cytochrome P-450 monooxygenase: substrate specificity and physiological activity A Zimmerlin, F Durst Plant physiology 100 (2), 874-881, 1992 | 114 | 1992 |
| CYP3A time-dependent inhibition risk assessment validated with 400 reference drugs A Zimmerlin, M Trunzer, B Faller Drug metabolism and disposition 39 (6), 1039-1046, 2011 | 96 | 2011 |
| SAR of 2, 6-diamino-3, 5-difluoropyridinyl substituted heterocycles as novel p38 MAP kinase inhibitors L Revesz, FE Di Padova, T Buhl, R Feifel, H Gram, P Hiestand, ... Bioorganic & medicinal chemistry letters 12 (16), 2109-2112, 2002 | 87 | 2002 |
| Xenobiotic metabolism in plants: aryl hydroxylation of diclofop by a cytochrome P-450 enzyme from wheat A Zimmerlin, F Durst Phytochemistry 29 (6), 1729-1732, 1990 | 84 | 1990 |
| Regulation of the cinnamate 4-hydroxylase (CYP73A1) in Jerusalem artichoke tubers in response to wounding and chemical treatments Y Batard, M Schalk, MA Pierrel, A Zimmerlin, F Durst, D Werck-Reichhart Plant physiology 113 (3), 951-959, 1997 | 82 | 1997 |
| Synthesis of dehydrogenation polymers of ferulic acid with high specificity by a purified cell-wall peroxidase from French bean (Phaseolus vulgaris L.) A Zimmerlin, P Wojtaszek, GP Bolwell Biochemical Journal 299 (3), 747-753, 1994 | 77 | 1994 |
| CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis Y Jin, M Zollinger, H Borell, A Zimmerlin, CJ Patten Drug metabolism and disposition 39 (2), 191-198, 2011 | 74 | 2011 |
| SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors L Revesz, FE Di Padova, T Buhl, R Feifel, H Gram, P Hiestand, ... Bioorganic & medicinal chemistry letters 10 (11), 1261-1264, 2000 | 74 | 2000 |
| Evaluation of Fluorescence-and Mass Spectrometry–Based CYP Inhibition Assays for Use in Drug Discovery L Bell, S Bickford, PH Nguyen, J Wang, T He, B Zhang, Y Friche, ... SLAS Discovery 13 (5), 343-353, 2008 | 69 | 2008 |
| Optimized expression and catalytic properties of a wheat obtusifoliol 14α‐demethylase (CYP51) expressed in yeast F Cabello‐Hurtado, M Taton, N Forthoffer, R Kahn, S Bak, A Rahier, ... European Journal of Biochemistry 262 (2), 435-446, 2001 | 60 | 2001 |
| Cloning and functional expression in yeast of a cDNA coding for an obtusifoliol 14α-demethylase (CYP51) in wheat F Cabello-Hurtado, A Zimmerlin, A Rahier, M Taton, R DeRose, ... Biochemical and biophysical research communications 230 (2), 381-385, 1997 | 47 | 1997 |
| Cytochrome P-450-dependent hydroxylation of lauric acid at the subterminal position and oxidation of unsaturated analogs in wheat microsomes A Zimmerlin, JP Salaun, F Durst, C Mioskowski Plant physiology 100 (2), 868-873, 1992 | 44 | 1992 |
| Induction and inactivation of a cytochrome P450 confering herbicide resistance in wheat seedlings N Forthoffer, C Helvig, N Dillon, I Benveniste, A Zimmerlin, F Tardif, ... European journal of drug metabolism and pharmacokinetics 26, 9-16, 2001 | 40 | 2001 |
