C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging TJ Van Ham, KL Thijssen, R Breitling, RMW Hofstra, RHA Plasterk, ... PLoS genetics 4 (3), e1000027, 2008 | 487 | 2008 |
Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration TM Tsarouchas, D Wehner, L Cavone, T Munir, M Keatinge, M Lambertus, ... Nature communications 9 (1), 4670, 2018 | 266 | 2018 |
Homozygous mutations in CSF1R cause a pediatric-onset leukoencephalopathy and can result in congenital absence of microglia N Oosterhof, IJ Chang, EG Karimiani, LE Kuil, DM Jensen, R Daza, ... The American Journal of Human Genetics 104 (5), 936-947, 2019 | 229 | 2019 |
Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity TJ van Ham, MA Holmberg, AT van der Goot, E Teuling, ... Cell 142 (4), 601-612, 2010 | 177 | 2010 |
Live imaging of apoptotic cells in zebrafish TJ van Ham, J Mapes, D Kokel, RT Peterson The FASEB Journal 24 (11), 4336, 2010 | 158 | 2010 |
Colony-stimulating factor 1 receptor (CSF1R) regulates microglia density and distribution, but not microglia differentiation in vivo N Oosterhof, LE Kuil, HC van der Linde, SM Burm, W Berdowski, ... Cell reports 24 (5), 1203-1217. e6, 2018 | 142 | 2018 |
Chaperone proteostasis in Parkinson's disease: Stabilization of the Hsp70/α‐synuclein complex by Hip C Roodveldt, CW Bertoncini, A Andersson, AT Van Der Goot, ST Hsu, ... The EMBO journal 28 (23), 3758-3770, 2009 | 138 | 2009 |
Identification of nonvisual photomotor response cells in the vertebrate hindbrain D Kokel, TW Dunn, MB Ahrens, R Alshut, CYJ Cheung, L Saint-Amant, ... Journal of Neuroscience 33 (9), 3834-3843, 2013 | 136 | 2013 |
Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis MI Cunha, M Su, L Cantuti-Castelvetri, SA Müller, M Schifferer, ... Journal of Experimental Medicine 217 (5), e20191390, 2020 | 135 | 2020 |
A FRET sensor for non‐invasive imaging of amyloid formation in vivo GS Kaminski Schierle, CW Bertoncini, FTS Chan, AT Van Der Goot, ... ChemPhysChem 12 (3), 673-680, 2011 | 133 | 2011 |
Neurodegenerative diseases: lessons from genome‐wide screens in small model organisms TJ Van Ham, R Breitling, MA Swertz, EAA Nollen EMBO molecular medicine 1 (8‐9), 360-370, 2009 | 107 | 2009 |
A small molecule that induces intrinsic pathway apoptosis with unparalleled speed R Palchaudhuri, MJ Lambrecht, RC Botham, KC Partlow, TJ Van Ham, ... Cell reports 13 (9), 2027-2036, 2015 | 97 | 2015 |
Towards multiparametric fluorescent imaging of amyloid formation: studies of a YFP model of α-synuclein aggregation TJ van Ham, A Esposito, JR Kumita, STD Hsu, GSK Schierle, CF Kaminski, ... Journal of molecular biology 395 (3), 627-642, 2010 | 91 | 2010 |
Whole exome sequencing coupled with unbiased functional analysis reveals new Hirschsprung disease genes H Gui, D Schriemer, WW Cheng, RK Chauhan, G Antiňolo, C Berrios, ... Genome biology 18, 1-13, 2017 | 89 | 2017 |
Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish N Oosterhof, IR Holtman, LE Kuil, HC van der Linde, EWGM Boddeke, ... Glia 65 (1), 138-149, 2017 | 89 | 2017 |
Apoptotic cells are cleared by directional migration and elmo1-dependent macrophage engulfment TJ van Ham, D Kokel, RT Peterson Current Biology 22 (9), 830-836, 2012 | 86 | 2012 |
Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation TJ van Ham, CA Brady, RD Kalicharan, N Oosterhof, J Kuipers, ... Disease models & mechanisms 7 (7), 857-869, 2014 | 67 | 2014 |
Gene expression profiling reveals a conserved microglia signature in larval zebrafish J Mazzolini, S Le Clerc, G Morisse, C Coulonges, LE Kuil, TJ Van Ham, ... Glia 68 (2), 298-315, 2020 | 64 | 2020 |
Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases E Perenthaler, A Nikoncuk, S Yousefi, WM Berdowski, M Alsagob, I Capo, ... Acta neuropathologica 139, 415-442, 2020 | 62 | 2020 |
Immune cell dynamics in the CNS: Learning from the zebrafish N Oosterhof, E Boddeke, TJ van Ham Glia 63 (5), 719-735, 2015 | 57 | 2015 |