| RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS Y Ito, D Ofengeim, A Najafov, S Das, S Saberi, Y Li, J Hitomi, H Zhu, ... Science 353 (6299), 603-608, 2016 | 584 | 2016 |
| Activation of necroptosis in multiple sclerosis D Ofengeim, Y Ito, A Najafov, Y Zhang, B Shan, JP DeWitt, J Ye, X Zhang, ... Cell reports 10 (11), 1836-1849, 2015 | 534 | 2015 |
| Necroptosis in development and diseases B Shan, H Pan, A Najafov, J Yuan Genes & development 32 (5-6), 327-340, 2018 | 353 | 2018 |
| Roles of caspases in necrotic cell death J Yuan, A Najafov, BF Py Cell 167 (7), 1693-1704, 2016 | 302 | 2016 |
| Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis J Geng, Y Ito, L Shi, P Amin, J Chu, AT Ouchida, AK Mookhtiar, H Zhao, ... Nature communications 8 (1), 359, 2017 | 284 | 2017 |
| Necroptosis and cancer A Najafov, H Chen, J Yuan Trends in cancer 3 (4), 294-301, 2017 | 202 | 2017 |
| Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1 A Najafov, EM Sommer, JM Axten, MP Deyoung, DR Alessi Biochemical Journal 433 (2), 357-369, 2011 | 161 | 2011 |
| Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNFα-mediated apoptosis P Amin, M Florez, A Najafov, H Pan, J Geng, D Ofengeim, SA Dziedzic, ... Proceedings of the National Academy of Sciences 115 (26), E5944-E5953, 2018 | 150 | 2018 |
| Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer’s disease mouse model X Cen, Y Chen, X Xu, R Wu, F He, Q Zhao, Q Sun, C Yi, J Wu, A Najafov, ... Nature communications 11 (1), 5731, 2020 | 145 | 2020 |
| Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death H Xia, A Najafov, J Geng, L Galan-Acosta, X Han, Y Guo, B Shan, ... Journal of Cell Biology 210 (5), 705-716, 2015 | 125 | 2015 |
| TAM kinases promote necroptosis by regulating oligomerization of MLKL A Najafov, AK Mookhtiar, HS Luu, A Ordureau, H Pan, PP Amin, Y Li, Q Lu, ... Molecular cell 75 (3), 457-468. e4, 2019 | 120 | 2019 |
| The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans ML Landsverk, S Li, AH Hutagalung, A Najafov, T Hoppe, JM Barral, ... Journal of Cell Biology 177 (2), 205-210, 2007 | 118 | 2007 |
| Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model X Xu, Y Sun, X Cen, B Shan, Q Zhao, T Xie, Z Wang, T Hou, Y Xue, ... Protein & cell 12 (10), 769-787, 2021 | 111 | 2021 |
| G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L T Zhang, K Dong, W Liang, D Xu, H Xia, J Geng, A Najafov, M Liu, Y Li, ... elife 4, e06734, 2015 | 105 | 2015 |
| Clinicopathological and genetic study of early-onset demyelinating neuropathy Y Parman, E Battaloğlu, I Barış, B Bilir, M Poyraz, N Bissar-Tadmouri, ... Brain 127 (11), 2540, 2004 | 101 | 2004 |
| ABIN-1 regulates RIPK1 activation by linking Met1 ubiquitylation with Lys63 deubiquitylation in TNF-RSC SA Dziedzic, Z Su, V Jean Barrett, A Najafov, AK Mookhtiar, P Amin, ... Nature cell biology 20 (1), 58-68, 2018 | 100 | 2018 |
| ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation Y Wu, C Zhang, X Liu, Z He, B Shan, Q Zeng, Q Zhao, H Zhu, H Liao, ... Nature communications 12 (1), 2346, 2021 | 87 | 2021 |
| Modulating TRADD to restore cellular homeostasis and inhibit apoptosis D Xu, H Zhao, M Jin, H Zhu, B Shan, J Geng, SA Dziedzic, P Amin, ... Nature 587 (7832), 133-138, 2020 | 86 | 2020 |
| BRAF and AXL oncogenes drive RIPK3 expression loss in cancer A Najafov, IK Zervantonakis, AK Mookhtiar, P Greninger, RJ March, ... PLoS biology 16 (8), e2005756, 2018 | 81 | 2018 |
| Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors A Najafov, N Shpiro, DR Alessi Biochemical Journal 448 (2), 285-295, 2012 | 79 | 2012 |
Jiefei GengHarvard Medical SchoolEmail yang diverifikasi di hms.harvard.edu
