Cikkek nyilvánosan hozzáférhető megbízással - Oleg FedorovTovábbi információ
Sehol sem hozzáférhető: 8
Áttekintés
Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase
AN Bullock, JÉ Debreczeni, OY Fedorov, A Nelson, BD Marsden, S Knapp
Journal of medicinal chemistry 48 (24), 7604-7614, 2005
Megbízások: Genome Canada
Áttekintés
Type II inhibitors targeting CDK2
LT Alexander, H Möbitz, P Drueckes, P Savitsky, O Fedorov, JM Elkins, ...
ACS chemical biology 10 (9), 2116-2125, 2015
Megbízások: Genome Canada, UK Engineering and Physical Sciences Research Council …
Áttekintés
Insights for the development of specific kinase inhibitors by targeted structural genomics
O Fedorov, M Sundström, B Marsden, S Knapp
Drug discovery today 12 (9-10), 365-372, 2007
Megbízások: Genome Canada
Áttekintés
Catalyst-free synthesis of fused triazolo-diazepino [5, 6-b] quinoline derivatives via a sequential Ugi-4CR–nucleophilic substitution–intramolecular Click reaction
S Balalaie, A Vaezghaemi, N Zarezadeh, F Rominger, HR Bijanzadeh
Synlett 29 (08), 1095-1101, 2018
Megbízások: UK Medical Research Council
Áttekintés
Discovery of high-affinity small-molecule binders of the epigenetic reader YEATS4
AT Londregan, K Aitmakhanova, J Bennett, LJ Byrnes, DP Canterbury, ...
Journal of Medicinal Chemistry 66 (1), 460-472, 2022
Megbízások: European Commission
Áttekintés
RhoB can adopt a Mg2+ free conformation prior to GEF binding
M Soundararajan, A Turnbull, O Fedorov, C Johansson, DA Doyle
Proteins: Structure, Function, and Bioinformatics 72 (1), 498-505, 2008
Megbízások: Canadian Institutes of Health Research, Genome Canada
Áttekintés
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3
B Raux, KA Buchan, J Bennett, T Christott, MS Dowling, G Farnie, ...
Bioorganic & Medicinal Chemistry Letters 98, 129546, 2024
Megbízások: European Commission, Ontario Institute for Cancer Research
Áttekintés
A Transcription-uncoupled Negative Feedback Loop for the 1 WNT Pathway: WNT Activates the AAK1 Kinase to Promote Clathrin-mediated Endocytosis of LRP6
MJ Agajanian, MP Walker, AD Axtman, RR Ruela-de-Sousa, ...
Megbízások: US National Institutes of Health, Genome Canada, Cancer Research UK …
Valahol hozzáférhető: 110
Áttekintés
Selective inhibition of BET bromodomains
P Filippakopoulos, J Qi, S Picaud, Y Shen, WB Smith, O Fedorov, ...
Nature 468 (7327), 1067-1073, 2010
Megbízások: US National Institutes of Health, Canadian Institutes of Health Research …
Áttekintés
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
Megbízások: Genome Canada
Áttekintés
RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain
S Picaud, C Wells, I Felletar, D Brotherton, S Martin, P Savitsky, ...
Proceedings of the National Academy of Sciences 110 (49), 19754-19759, 2013
Megbízások: Canadian Institutes of Health Research, Genome Canada, Wellcome Trust
Áttekintés
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
O Fedorov, B Marsden, V Pogacic, P Rellos, S Müller, AN Bullock, ...
Proceedings of the National Academy of Sciences 104 (51), 20523-20528, 2007
Megbízások: Genome Canada
Áttekintés
Dual kinase-bromodomain inhibitors for rationally designed polypharmacology
P Ciceri, S Müller, A O'mahony, O Fedorov, P Filippakopoulos, JP Hunt, ...
Nature chemical biology 10 (4), 305-312, 2014
Megbízások: US National Institutes of Health, Canadian Institutes of Health Research …
Áttekintés
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
DA Hay, O Fedorov, S Martin, DC Singleton, C Tallant, C Wells, S Picaud, ...
Journal of the American Chemical Society 136 (26), 9308-9319, 2014
Megbízások: US National Institutes of Health, Canadian Institutes of Health Research …
Áttekintés
Rapid covalent-probe discovery by electrophile-fragment screening
E Resnick, A Bradley, J Gan, A Douangamath, T Krojer, R Sethi, ...
Journal of the American Chemical Society 141 (22), 8951-8968, 2019
Megbízások: Genome Canada, Netherlands Organisation for Scientific Research, UK Medical …
Áttekintés
PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains
S Picaud, D Da Costa, A Thanasopoulou, P Filippakopoulos, PV Fish, ...
Cancer research 73 (11), 3336-3346, 2013
Megbízások: Swiss National Science Foundation, US National Institutes of Health …
Áttekintés
CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses
A Hammitzsch, C Tallant, O Fedorov, A O’Mahony, PE Brennan, DA Hay, ...
Proceedings of the National Academy of Sciences 112 (34), 10768-10773, 2015
Megbízások: Genome Canada, German Research Foundation, Versus Arthritis, UK, National …
Áttekintés
3, 5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands
DS Hewings, M Wang, M Philpott, O Fedorov, S Uttarkar, ...
Journal of medicinal chemistry 54 (19), 6761-6770, 2011
Megbízások: Canadian Institutes of Health Research, Genome Canada, Cancer Research UK
Áttekintés
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit
PV Fish, P Filippakopoulos, G Bish, PE Brennan, ME Bunnage, AS Cook, ...
Journal of medicinal chemistry 55 (22), 9831-9837, 2012
Megbízások: Canadian Institutes of Health Research, Genome Canada
Áttekintés
Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy
S Picaud, O Fedorov, A Thanasopoulou, K Leonards, K Jones, J Meier, ...
Cancer research 75 (23), 5106-5119, 2015
Megbízások: Swiss National Science Foundation, Canadian Institutes of Health Research …
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